Kazan Meslek Yüksekokulu / Kazan Vocational School

Permanent URI for this collectionhttps://hdl.handle.net/11727/2077

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    Fetal HLA-G alleles and their effect on miscarriage
    (2018) Kubat, Gozde; Koc, Altug; Kirbiyik, Ozgur; Kutbay, Yasar B.; Ozyilmaz, Berk; Ozdemir, Taha R.; Kaya, Ozge Ozer; Koc, Zeynep Peker; 29809322
    Background. Immunosuppression at the feto-maternal interface is crucial for a successful pregnancy outcome. Human leukocyte antigen-G (HLA-G) seems to be a major contributor to fetal tolerance. The HLA-G expression is seen in cytotrophoblasts and in maternal blood. Fetal HLA-G acts on decidual antigen-presenting cells (APCs), natural killers (NKs) and T cells. Recent findings revealed that defects in placentation and their consequences are associated with maternal HLA-G variants and their expression levels. Objectives. The objective of this article is to investigate the relationship between fetal HLA-G alleles and miscarriage, which has not been investigated to date. Material and methods. The present study includes 204 recurrent miscarriage (RM) cases who were admitted to our clinic between 2012 and 2016. Twenty-eight miscarriage products without maternal cell contamination and any known pathology were analyzed by HLA-G typing. In addition, 3' untranslated region (UTR) 14-base pair (bp) insertion/deletion polymorphism was also investigated by Sanger sequencing. Results. For our population, the most frequent HLA-G type was G*01:01, both in the study group (30.3%) and in the control group (47%). The study revealed that the G*01:04 allele was significantly associated with miscarriage (p = 0.007). The 3' UTR 14bp deletion was more frequent in the miscarriage group, but there was no significant correlation. Conclusions. HLA-G alleles seem to be related with miscarriage and should be considered in RM cases.
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    THE APPROACH OF ATATURK TO RELATIONS BETWEEN TURKEY AND ALBANIA BEFORE THE PROCLAMATION OF MONARCHY, IN THE LIGHT OF THE DIARIES OF RAUF FICO, THE MINISTER PLENIPOTENTIARY OF ANKARA
    (2018) Ozca, Halil
    The diaries of RaufFico, Albanian Minister Plenipotentiary to Ankara, gives a lot of useful information about Albania-Turkey relations that had not been stumbled across in the literature until today. The aim of this study is to point out Atatiirk's views on relations between Albania and Turkey, Albania and Italy, as well as his suggestions to Albanian envoy in Ankara about how to overcome the Albanian dependency on Italy. The research is based on the diaries of Fico, Albanian Minister Plenipotentiary to Ankara. The study is limited with focusing on the Italian factor in Albania's relations with Turkey rather than examining all aspects of the relationship between the two independent countries. Fico had had formal education in the Ottoman Empire and occupied bureaucratic posts such as being provincial governor and following independence of Albania started to work for Albanian government as an important diplomat. Therefore, his diaries provide us a plenty of information on the question of Albania's relations with Turkey as well as with Italy, particularly between 1925 and 1928 during which there had been a Republican regime in Albania. In fact, Fico's diaries give perfect information about close relations between Turkey and Albania and the importance given by Mustafa Kemal Atatiirk on these relations at bilateral level, at least until the destruction of the Republican regime by Ahmet Zogu who would proclaim himself as the King of Albania in 1928. The content of the Fico's diaries are very rich in a way that they consist problems of Orthodox Albanians in Istanbul, positions of Albanians in Kosovo, the exchange of Albanian Chams, reforms in Turkey, assassination attempt to Atatirk in izmir and main themes in Nutuk. It should be kept in mind that the scope of this study is confined, first, to suggestions of Ataturk to the Albanian government regarding getting rid of dependency on Italy, and second, to his foresight about Italy's position towards Albania and Turkey. In this respect, the Fico's diaries give invaluable information on all these subjects elaborated in this paper.