Başkent Üniversitesi Makaleler

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Subject: search.filters.subject.Saudi Arabia

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    Is There a Bias Against Women in Kidney Transplantation Practices in Saudi Arabia?
    (Başkent Üniversitesi, 2006-12) Hejaili, F.; Juhani, A.; Flaiw, A.; Ghamdi, G.; Jondeby, M.; Eid, A.; Jaradat, M.; Shaheen, F.; Al Khader, A.
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    Implications of ICU Stay After Brain Death: The Saudi Experience
    (Başkent Üniversitesi, 2006-12) Al-Attar, Besher; Shaheen, Faissal; Salam, Mohammed Abdul; Al-Sayyari, Abdullah; Babiker, Abdulqayoum; Zakaria, Haroun; Babiker, Ahmed; Saclayan, Levi
    Objective: The interval from brain death (BD) to organ harvesting is critical to the success of transplantation. We evaluated the time from BD onset to harvesting and analyzed sources of delay. Materials and Methods: This retrospective study was conducted from January 1999 to December 2003. Time intervals analyzed to determine the causes of delay were: time of admission to the intensive care unit (ICU), to the report to the Saudi Center for Organ Transplantation (SCOT), to the documentation of BD, to organ retrieval and/or cardiocirculatory cessation without organ retrieval. Results: During the 5-year analysis, 1834 people were reported to the SCOT. Of those, more than 1511 (80%) were reported during their first week of treatment in the ICU, and BD was documented in 1099 (59.9%). The mean interval from ICU admission to organ retrieval or cardiac arrest was 10.3 days and that from admission to the report to the SCOT was 5.6 days. In the consensual group, the mean interval from the documentation of BD until harvesting was 2 days, and that from documentation until cardiocirculatory cessation without organ retrieval in the nonconsensual group was 5 days. All subjects demonstrated a significant decrease in systolic blood pressure and a significant increase in plasma sodium and serum creatinine levels. The body temperature, serum plasma levels of sodium, and kidney function (measured by the serum creatinine level) of potential donors were compared, and patients with hypothermia, hypernatremia, or renal failure had a shorter stay in the ICU. Conclusions: Fewer than 30% of the patients could be maintained on mechanical support for more than 1 week after the declaration BD. It is crucial that we increase hospital-staff awareness about the importance of organ donation and transplantation, improve the identification of BD candidates, and enable the early reporting and documentation of BD.
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    The Relationship Between HLA Typing and HCV Infection and Outcome of Renal Transplantation in HCV Positive Patients
    (Başkent Üniversitesi, 2003-06) Hadhoud, Alaa; Abdulaziz, Azza M.; Al Menawi, Lubna; Shaheen, F.A.; Abdulghaffar, Aliah; Abas, Fahd Al; F. Al Mobrak, Mohammed
    The role of Human Leukocytic Antigen (HLA) antigens in susceptibility to Hepatitis C Virus (HCV) infection is still being debated. We analyzed HLA phenotype frequencies in two major ethnic groups, namely Egyptian and Saudi nationals. The Egyptian group included 110 patients of whom 55 were HCV positive and the other 55 HCV negative (control group). The Saudi group included 146 HCV positive patients and 122 HCV negative individuals (control group). The results for the Egyptian population revealed increased frequencies of some HLA phenotypes and decreased frequencies of others but without any statistically significant difference. In contrast, in the Saudi population, the HLA-A19 phenotype was significantly increased in HCV positive patients when compared with the control group while significantly decreased frequencies were found for HLA-B8, HLA-DRI and HLA DR3. Our data suggest that there was no significant association between HLA phenotypes and susceptibility to HCV infection among the Egyptian population while the overall data of the Saudi population seem to indicate that the expression of particular HLA alleles could be associated with susceptibility or resistance to the HCV infection. Further studies on larger numbers of patients are needed to support the role of the HLA system in HCV infection. A total of 108 HCV positive patients underwent renal transplantation at the Jeddah Kidney Center and the results were compared with 100 age and sex-matched controls. Graft survival at 36 months was 82% and 86% for HCV positive and control subjects respectively while patient survival was respectively 90% and 91%. Our data suggest that the outcome, at least in the short-time, of renal transplantation in HCV positive patients is very good.