Wos İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4807
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Item Is There A Secular Trend Regarding Puberty In Children With Down Syndrome?(2022) Erdogan, Furkan; Guven, Ayla; 36457553IntroductionThere are very few studies on the age of onset and end of puberty in children with Down syndrome (DS). Also, data regarding the course of puberty in these children compared to their healthy peers is limited. Moreover, there is limited information regarding the effects of factors such as obesity and hypothyroidism on the puberty process in children with DS. Our aim in our study is to determine whether the pubertal development of children with DS differs from their healthy peers and from previous studies conducted with DS children. MethodsThe medical records of DS children were examined retrospectively. The anthropometric measurements and the age of onset of pubertal stages, and menarche were recorded. The patients' age at puberty onset, the puberty processes, and age at menarche were compared with their healthy peers and previously published data on children with DS. ResultsOf the 140 Down syndrome patients followed in our clinic, 51 of whom with puberty constituted the study group. The mean age of onset of puberty was 10.3 +/- 1.0 years in our group (10.0 +/- 0.8 years for girls, 10.6 +/- 1.2 years for boys, respectively). Obesity occurred in 46% of pubertal girls with DS. The age of menarche in girls with DS was 11.8 +/- 0.7 years. The menarche age of girls with DS was significantly different from healthy girls. In the DS boys, only the Tanner V stage ages were different from the healthy children. True- precocious-puberty was detected in three children. ConclusionAlthough breast development begins later in females with DS than in their healthy peers; menarche is detected earlier than in their peers and a tendency towards obesity in the whole population. While the age of pubertal onset was similar to healthy children in male patients, our findings suggest that their puberty duration is longer.Item Etiology of Increased Referrals for Evaluation of Early Puberty in a Tertiary Care Center in Turkey: True Precocious Puberty, Obesity, or Parental Anxiety and Lack of Knowledge?(2021) Cemeroglu, Ayse Pinar; Kaval, Damlanur; Ozcan, Ozan; 0000-0002-1653-7932; 0000-0002-9421-0855; 0000-0002-3430-5203; 33889682There has been a global increase in pediatric endocrinology referrals for the concerns of early puberty. The objective of this study was to determine the reasons behind this increase. A retrospective cross-sectional study was designed to analyze the clinical characteristics of patients seen for the concerns of early puberty in pediatric endocrinology clinic of a tertiary care center (Study A). Additionally, a prospective questionnaire study was designed to assess the knowledge and concerns of the mothers regarding the timing of puberty in girls (Study B). In study A, of the 305 girls, 42.9% were overweight/obese, 68.5% either had normal pubertal development for age or were prepubertal, 1 had non-classic congenital adrenal hyperplasia, and 2 had central precocious puberty. Of the 36 boys, 56% were overweight/obese, 64% either had normal pubertal development for age or were prepubertal, and 1 had non-classic congenital adrenal hyperplasia. In study B, 95% of the participants thought the girls have been developing earlier, over 10% considered the first sign of puberty to be normal after the age 14 years and 12.4% considered menarche to be normal after age 14 years. The common sources of anxiety for the participants regarding the earlier timing of puberty were psychosocial issues and short final height. In conclusion, many parents had wrong beliefs/information about the normal timing of puberty and were concerned about precocious puberty in girls. Education of parents about the normal timing of puberty may help avoiding unnecessary referrals, parental anxiety, and financial burden to the society.Item Is There a Relationship Between Insulin Resistance and Breast Cancer-Related Lymphedema? A Preliminary Study(2021) Doruk Analan, Pinar; Kaya, Emine; 33761281Background: High blood insulin levels, insulin resistance (IR), and obesity are components of metabolic syndrome (MetS). The literature has indicated a high risk of breast cancer in patients with MetS. However, no studies have been conducted evaluating the relationship between breast cancer-related lymphedema (BCRL), one of the most frequently encountered postbreast cancer treatment conditions, and IR. Therefore, the aim of this study was to evaluate whether there is a relationship between BCRL and IR. Methods and Results: A total of 28 patients diagnosed with breast carcinoma were included in this preliminary study. Patients were divided into BCRL (n = 15; mean age: 55.2 +/- 11.2 years) and non-BCRL (control) groups (n = 13; mean age: 55.17 +/- 6.57 years). Body mass index (BMI), waist and hip circumference, and fasting blood glucose and blood insulin levels of all patients were recorded. The Homeostasis Model Assessment (HOMA) test was used for the calculation of IR measurement with a value of 2.5 taken as an indicator of IR. Parameters were compared between groups. BMI, waist circumference measurements, blood insulin, and HOMA-IR levels were statistically significantly higher in the BCRL group than the control group (p < 0.05). HOMA-IR values >2.5 were found in 14 patients in the BCRL group. In the control group, only three patients had IR based on HOMA-IR criteria (p = 0.000). Hip circumference measurements and fasting blood glucose levels were similar between the groups (p > 0.05). Conclusions: BCRL appears to be associated with waist circumference, fasting blood insulin level, and HOMA-IR levels. In routine clinical practice, evaluation of IR may be important in the follow-up of this patient population.Item BMI, Physical Activity, Sleep Quality, Eating Attitudes, Emotions: Which One is Affected by Mindful Eating?(2021) Kose, Gizem; Tayfur, MuhittinPresent study, it was aimed to examine the eating attitude and mindful eating status of students and to examine the change of mindful eating status' besides informing with nutrition course. The study was executed by 318 healthy students aged 18-45 years, randomly selected among students studying at Uskudar University between September 2015 and May 2016. In addition to a survey form containing personal and health information of the students, the Eating Attitudes Test (EAT-40) was conducted by Savasir and Erol, and the Mindful Eating Questionnare-30 (MEQ-30) scale conducted by Turkish Kose et al. The mean age of the participants was 21.56 +/- 3.82 year. The mean score of the participants' EAT-40 score was found to be 24.22 +/- 13.98 and the mean score of the MEQwas 98.11 +/- 13.81. As the EAT-40 scores decreased, MEQ scores increased, but this relationship was not statistically significant (p> 0.05). It has been shown that 28.9% of students have an eating disorder risk. There was no statistically significant difference between men's (23.33 +/- 15.60) and women's (24.48 +/- 13.50) mean EAT-40 scores (p>0.05). Overweight-obese group was found to be having higher EAT-40 scores than the other BMI classes (p <0.05). While the students' body weight and BMI increased, the risk of eating disorder increased (r = 0.112, p <0.05 and r = 0.139, p <0.05), and mindful eating decreased (p> 0.05). A significant relationship was found between weight, BMI and MEQ subscales (r =-0.252, p <0.01 and r =-0.208, p<0.01). As food preferences evaluated, 33.3% of students that is vegan, 26.4% of the students that have no food preference and 24.1% of the students that don't eat red meat were at risk of eating disorder (p <0.05). There was no statistically significant difference between the EAT-40 score groups according to walking status of the participants (p> 0.05). There was a statistically significant relationship between walking status and emotional eating that is one of MEQ subscales (r = -0.159, p <0.01). As having nutrition course, EAT-40 score decreased and the score of MEQ increased (p> 0.05). There was no statistically significant relationship between the level of taking the course and EAT-40, MEQ or the subscales of MEQ (p> 0.05). In sum, nutrition courses influence students' eating attitudes and mindful eating positively. In addition, gaining mindfulness of eating will be helping manage to weight status.Item Evaluation of clinical, endocrine and metabolic findings in obese children with and without hepatosteatosis(2021) Basarir, Gunce; Ozcabi, Bahar; Sayman, Ozden Aksu; Akay, Hatice Ozturkmen; Yildiz, Feyza M.; 34142516Objectives: Non-alcoholic fatty liver disease (NAFLD) is a common obesity-related comorbidity in childhood. In this study, we aimed to evaluate predictors of NAFLD by comparing clinical, endocrine and metabolic findings in obese children with and without hepatosteatosis. Methods: Two hundred and eight obese children aged 6-18 years were included. The patients were divided into group 1 (patients with NAFLD, n=94) and group 2 (patients without NAFLD, n=114). Anthropometric measurements, pubertal stage, lipid profiles, fasting glucose and insulin, homeostatic model of assessment for insulin resistance (HOMA-IR), uric acid, total bilirubin, alanine aminotransferase (ALT), blood urea nitrogen, thyroid-stimulating hormone and free thyroxine parameters were compared retrospectively. Results: The mean body weight, body mass index (BMI), height, tri-ponderal mass index (TMI), insulin, HOMA-IR, triglyceride, ALT and uric acid values were significantly higher, while high-density lipoprotein-cholesterol (HDL-C) values were significantly lower in group 1. The 70.7% of obese children with hepatosteatosis and 83.9% of those without hepatosteatosis were correctly estimated by parameters including age, gender, ALT, HDL-C, fasting insulin and uric acid values. Conclusions: Since obesity-associated hepatosteatosis induces various long-term metabolic impacts in children, early detection is of critical importance. Age, gender, TMI, BMI, ALT, HDL-C, fasting insulin and uric acid values may help to predict the risk of hepatosteatosis. Besides, we assessed whether TMI compared to BMI does not have a better utility in estimating obesity-induced hepatosteatosis in children. This is the first study to show the association between TMI and hepatosteatosis in children.Item Outcome of Gastric Fundus and Pylorus Botulinum Toxin A Injection in Obese Patients Class I-II with Normal Pyloric Orifice Structure: A Retrospective Analysis(2021) Ferhatoglu, Murat Ferhat; Kartal, Abdulcabar; Filiz, Ali Ilker; Kebudi, AbutBackground: Any deterioration in pyloric muscle activity has the potential to influence gastric emptying. In such a case, gastric emptying time would also be changed due to the paralysis of pyloric muscles, which is the botulinum toxin's effect mechanism. This study aimed to investigate how the pyloric orifice structure influences the success of intragastric botulinum toxin type A injection (GBI) therapy in Class I-II obese patients for weight loss.Methods: The GBI applied patients were categorized according to pyloric orifice structure during upper gastrointestinal system endoscopy: Group A: the patients whose pylorus had normal peristaltic activity and closed completely and Group B: the patients whose pylorus did not close properly or were nonperistaltic. We measured the body mass index (BMI) of the patients before and 6 months after the procedure and expressed postprocedure weight loss in terms of the percentage of excess BMI (E-BMI%) loss. We compared preprocedure and sixth-month BMI and E-BMI% values. We applied the Student's t-test to analyze the differences among study groups, and p < 0.05 was accepted as statistically significant.Results: Seventy-seven patients completed the 6-month follow-up period. The measurements without considering the pyloric orifice structure showed that the mean BMI decrease in female patients (from 36.4 +/- 5.4 to 32 +/- 7.2 kg/m(2)) was significant (p < 0.05). And the BMI and E-BMI% loss in Group A were statistically significant (p < 0.05).Conclusion: We advise being selective and applying GBI to class I-II obese patients with normal pyloric orifice structure.Item Early pregnancy after bariatric surgery: a single-institute preliminary experience(2020) Gunakan, Emre; Bulus, Hakan; Tohma, Yusuf Aytac; 0000-0001-9418-4733; 31840970; AAE-6482-2021Background/aim: Pregnancy after bariatric surgery is an issue of growing importance with increasing number of women undergoing bariatric surgery. Therefore, in this study we present patients who conceived after sleeve gastrectomy and evaluate the obstetric outcomes. Materials and methods: This retrospective case-control study includes 23 women who conceived after laparoscopic sleeve gastrectomy. Patients were evaluated in two groups according to the number of months between surgery and conception (group 1: <= 12 months; group 2: >12 months). Results: The mean body mass index of patients before surgery and at the time of conception was 46.6 kg/m(2) and 29.7 kg/m(2), respectively. Nine patients (39.1%) had a history of infertility. There was no statistical difference between groups 1 and 2 for haemoglobin, ferritin, and 25-OH Vit-D levels or maternofoetal complication rates and pregnancy outcomes. Enteral nutrition requirements and intravenous iron replacement needs were higher in group 1, although this difference was not statistically significant. Conclusion: Pregnancy in the first years after sleeve gastrectomy seems to have similar obstetric outcomes compared to pregnancies occurring later, but it remains a controversial issue. Although the results did not have statistical significance in our study, well-designed prospective series may determine the role of enteral nutrition and intravenous iron replacement in patient management.Item Is Body Adiposity Index a Better and Easily Applicable Measure for Determination of Body Fat?(2020) Yesil, Esen; Kose, Beril; Ozdemir, Merve; 32155104Objective: The BAI can be used to reflect %body fat. This study aimed to compare BAI with other methods used in the determination of body fat. Materials and Methods: A cross-sectional study was conducted in Turkish adults. BAI, BMI, WHR, WHtR, body weight, hip and waist circumference (WC), skinfold thicknesses (biceps, triceps, subscapular, suprailiac) were measured. Body fat was measured using Bioelectric Impedance Analysis. Results: The Bland-Altman analyses conducted in this study showed that for % body fat estimations, BIA was in excellent agreement with skinfold measurements (p = 0.131) without proportional bias (p = 0.082), but that BAI was not in agreement with BIA and skinfold measurement. There were a statistically significant positive correlation between BAI and other measurements in terms of females and males and also regardless of sex. Conclusion: BAI was not in agreement with BIA and skinfold measurement methods for % body fat estimations, it had a significantly stronger correlation with % fat calculated using BIA and skinfold thickness.Item Effects of reproductive and sociodemographic factors on obesity in Turkish women: a pilot study(2019) Bayram, Sinem; Koseler, Esra; Kiziltan, Gul; Ok, Mebtap Akcil; Yesil, Esen; Kose, Beril; Ozdemir, Merve; Muftuoglu, Selen; Saka, Mendane; Aksoydan, Emine; Tayfur, Muhittin; Turker, Perim Fatma; Ercan, Aydan; 0000-0003-1569-7747; 0000-0002-4254-3711; AAF-4491-2021; AAG-6763-2020Background and aim: Obesity has become a global epidemic. The current research aimed to determine sociodemographic and reproductive predictors of obesity among Turkish women. Materials and methods: Eligible subjects (n:833) were 40-64 years-old women living in Turkey. A questionnaire consisted of questions about sociodemographic and reproductive factors and the International Physical Activity Questionnaire were applied to participants by face to face interviews. Multivariate logistic regression examined the risk of being obese with a range of sociodemographic and reproductive factors. All analyses were performed with SPSS software (version 17.0; SPSS, Chicago, Ill., USA). Results: The mean BMI of women aged 51-64 years was 30.59 +/- 6.35 kg/m(2). After adjustments for all other variables, increased obesity risk remained significant in women who had two children, housewifes, minimum active ones, ex smokers and had less than high school education. For multiple regression analysis sociodemographic factors from the bivariate analyses were entered, controlling for menarch age, menopausal age, hormone RT, parity, number of stillbirth, abortion. There was significant association between family income, occupation, education and BMI. Conclusion. In summary these findings showed comparable patterns of association of sociodemographic and reproductive factors with obesity in Turkey. Specific healthy lifestyle counseling is important for decreasing obesity in childbearing age women.Item Phosphodiesterase 4 inhibitor plus metformin is superior to metformin alone for the treatment of polycystic ovary syndrome: A rat model study(2019) Tohma, Yusuf Aytac; Onalan, Gogsen; Tepeoglu, Merih; Bayraktar, Nilufer; Colak, Eser; Ozcimen, Emel Ebru; Zeyneloglu, Hulusi Bulent; 30988783The role of metformin in the management of polycystic ovary syndrome (PCOS) and PCOS-related obesity remains controversial. Recent research on the treatment of PCOS-related obesity investigated novel therapeutic agents with the potential to work synergistically with metformin. The aim of the present study was to determine the synergistic effect of a phosphodiesterase 4 inhibitor (PDE4i) and metformin on weight and hormonal changes in a rat model of PCOS. A total of 40 female Sprague-Dawley rats were randomly divided into 4 groups (n=10/group): Sham; PCOS control (no medication after PCOS induction with dehydroepiandrosterone); metformin (300 mg/kg/day p.o. after PCOS induction); and metformin + PDE4i (300 mg/kg/day p.o. metformin + 0.5 mg/kg/day p.o. PDE4i after PCOS induction). The body weight was measured every 7 days, from day 1 to day 49. Vaginal smears were performed and examined daily via light microscopy for determination of the stage of each rat's estrous cycle. At the end of 21st day and at the end of the study, blood samples were collected from rats and the testosterone and insulin levels were measured. Immunohistochemical staining was performed to quantify phosphorylated cyclic AMP response element-binding protein expression in all groups. At the end of the study, the median body weight differed significantly among the groups ((2)=30.581, P<0.001), being the highest in the PCOS control group and the lowest in the metformin + PDE4i group. At the end of the study, the median testosterone level differed significantly among the groups ((2)=27.057, P<0.001), being the highest in the PCOS control group and the lowest in the metformin + PDE4i group. The cycle was restored to normal at the end of the study in all the rats in the metformin and metformin + PDE4i groups, whereas an irregular cycle persisted in all the rats in the PCOS control group. In conclusion, PDE4i + metformin was superior to metformin alone in reducing weight gain and decreasing the testosterone levels in a rat model of PCOS.