Wos İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4807
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Item Evaluation of Electrodermal Activity and Anxiety Behaviors in Diabetic Rats Given Vildagliptin and Metformin(2022) Shawesh, Muftah; Alshareef, Mohammed; Boyuk, Gulbahar; Yigit, Ayse Arzu; Dolu, NazanItem Determination of Audio-Visual Reaction Times in Individuals with Type 2 Diabetes Mellitus(2022) Bilaloglu, Melisa; Altay, Feride Pinar; Gul, Eylem; Ergun, Ahmet; Kiziltan, ErhanItem Quality assessment of web-based information on type 2 diabetes(2021) Olcer, Didem; 0000-0001-7736-1021Purpose This paper proposes a framework that automatically assesses content coverage and information quality of health websites for end-users. Design/methodology/approach The study investigates the impact of textual and content-based features in predicting the quality of health-related texts. Content-based features were acquired using an evidence-based practice guideline in diabetes. A set of textual features inspired by professional health literacy guidelines and the features commonly used for assessing information quality in other domains were also used. In this study, 60 websites about type 2 diabetes were methodically selected for inclusion. Two general practitioners used DISCERN to assess each website in terms of its content coverage and quality. Findings The proposed framework outputs were compared with the experts' evaluation scores. The best accuracy was obtained as 88 and 92% with textual features and content-based features for coverage assessment respectively. When both types of features were used, the proposed framework achieved 90% accuracy. For information quality assessment, the content-based features resulted in a higher accuracy of 92% against 88% obtained using the textual features. Research limitations/implications The experiments were conducted for websites about type 2 diabetes. As the whole process is costly and requires extensive expert human labelling, the study was carried out in a single domain. However, the methodology is generalizable to other health domains for which evidence-based practice guidelines are available. Practical implications Finding high-quality online health information is becoming increasingly difficult due to the high volume of information generated by non-experts in the area. The search engines fail to rank objective health websites higher within the search results. The proposed framework can aid search engine and information platform developers to implement better retrieval techniques, in turn, facilitating end-users' access to high-quality health information. Social implications Erroneous, biased or partial health information is a serious problem for end-users who need access to objective information on their health problems. Such information may cause patients to stop their treatments provided by professionals. It might also have adverse financial implications by causing unnecessary expenditures on ineffective treatments. The ability to access high-quality health information has a positive effect on the health of both individuals and the whole society. Originality/value The paper demonstrates that automatic assessment of health websites is a domain-specific problem, which cannot be addressed with the general information quality assessment methodologies in the literature. Content coverage of health websites has also been studied in the health domain for the first time in the literature.Item The Screening of Comorbid Depressive Disorders and Associated Risk Factors in Adult Patients with Type 2 Diabetes(2020) Demirci, Ibrahim; Haymana, Cem; Sonmez, Alper; Bolu, Abdullah; Kirnap, Nazli; Demir, Orhan; Meric, Coskun; Oysul, Guven; Aydogdu, Aydogan; Ersoz Gulcelik, Nese; Azal, OmerObjective: Elevated depressive symptoms and disorders affect one in five patients with diabetes. Current guidelines recommend screening depression in the diabetic population. Turkey has the highest (13.7%) prevalence of diabetes in Europe. However, there are limited data about the prevalence of depressive disorders among diabetic patients in Turkey. We aim to investigate the prevalence of a comorbid depressive disorder in Type 2 diabetic patients who were referred to the Endocrinology outpatient unit of a tertiary hospital. Material and Methods: All the Type 2 diabetic patients admitted to our endocrinology department were consecutively included in the study. Their sociodemographics, concomitant diseases and medications, macro and microvascular complications, lifestyle and personal habits, and treatment regimens were obtained by a specifically designed questionnaire. Laboratory data were obtained from the hospital records. The Patient Health Questionnaire-9 (PHQ-9), a depression screening tool, was used as a screening method for depression. Patients with a score of 10 or above determined high risk for depressive disorder according to PHQ-9. The scores were re-evaluated by a psychiatrist to minimize the false negative and positive results. Result: A total of 460 patients with Type 2 diabetic were enrolled in this crosssectional study. 18.9% (n=87) of the participants were found to have depressive disorders according to the psychiatric evaluation done after the PHQ-9 questionnaire. Patients with depressive disorders were predominantly female (69.0% vs. 55.5%; p=0.022), younger (57.2 +/- 10.5 vs. 60.0 +/- 9.5; p=0.014), had higher HbAlc (8.51 +/- 2.51 vs. 7.98 +/- 2.05; p=0.042), total cholesterol (205.6 +/- 44.2 vs. 194.2 +/- 46.0; p=0.045), LDL-cholesterol (123.1 +/- 37.8 vs. 113.1 +/- 35.4; p=0.026) and non-HDL-cholesterol (158.5 +/- 41.61 vs. 146.6 +/- 42.7; p=0.024). These patients had frequent neuropathy (37.3% vs. 19.0%, p=0.001), they were less likely to perform exerdse (31.8% vs. 53.1%; p<0.001) while smoke in excess (31.4% vs. 14.3%; p<0.001). The analysis showed that female gender (OR=4.4; 95% CI=1.6-12.8; p=0.005) and smoking (OR=7.6; 95% CI=2.8-20.5, p<0.001) are independent determinants of a depressive disorder. Conclusion: Approximately one-fifth of diabetic patients had a depressive disorder, and their metabolic parameters were worse than those without a depressive disorder. Therefore, to assess a diabetic patient from all aspects, screening for depressive disorder should be made an indispensable part of the evaluation process.Item HNF1A gene p.I27L is associated with early-onset, maturity-onset diabetes of the young-like diabetes in Turkey(2019) Beysel, Selvihan; Eyerci, Nilnur; Pinarli, Ferda Alparslan; Kizilgul, Muhammed; Ozcelik, Ozgur; Caliskan, Mustafa; Cakal, Erman; 31109344BackgroundThe molecular basis of the Turkish population with suspected maturity-onset diabetes of the young (MODY) has not been identified. This is the first study to investigate the association between HNF1A-gene single-nucleotide polymorphisms (SNPs) and having early-onset, MODY-like diabetes mellitus in the Turkish population.MethodsAll diabetic patients (N=565) who presented to our clinic between 2012 and 2015 with a clinical suspicion of MODY were included in the study. Analysis of HNF1A, HNFB, HNF4A, GCK gene mutations was performed using real-time polymerase chain reaction sequencing. After genetic analysis, diabetics (n=46) with HNF1A, HNF1B, HNF4A, GCK gene mutations (diagnosed as MODY) and diabetics (n=30) with HNF1B, HNF4A, GCK gene SNPs were excluded. Patients with early-onset, MODY-like diabetes (n=486) and non-diabetic controls (n=263) were included. Genetic analyses for the HNF1A gene p.S487N (rs2464196), p.A98V (rs1800574) and p.I27L (rs1169288) SNPs were performed using Sanger-based DNA sequencing among the control group.Resultsp.S487N and p.A98V was similar between the diabetics and controls in dominant and recessive models with no association (each, p>0.05). p.I27L GT/TT carriers (GT/TT vs. GG, OR=1.68, 95% CI: [1. 21-2.13]; p=0.035) and p.I27L TT carriers had increased risk of having MODY-like diabetes (GT/GG vs. TT, OR=1.56, 95% CI: [1. 14-2.57]; p=0.048). Family inheritance of diabetes was significantly more common in patients with the p.I27L TT genotype. The p.I27L SNP was modestly associated with having diabetes after adjusting for body mass index and age (=1.45, 95% CI: [1. 2-4.2]; p=0.036).ConclusionsThe HNF1A gene p.I27L SNP was modestly associated with having early-onset, MODY-like diabetes in the Turkish population. HNF1A gene p.I27L SNP might contribute to age at diabetes diagnosis and family inheritance.Item An international survey on hypoglycemia among insulin-treated type I and type II diabetes patients: Turkey cohort of the non-interventional IO HAT study(2018) Tutuncu, Neslihan Basci; Emral, Rifat; Tetiker, Tamer; Sahin, Ibrahim; Sari, Ramazan; Kaya, Ahmet; Yetkin, Ilhan; Cil, Sefika Uslu; 0000-0002-1816-3903; 29433560; ABG-5027-2020Background: Limited real-world data are currently available on hypoglycemia in diabetes patients. The International Operations Hypoglycemia Assessment Tool (IO HAT) study was designed to estimate hypoglycemia in insulin-treated type I (T1DM) and type II (T2DM) diabetes mellitus patients from 9 countries. The data from Turkey cohort are presented here. Methods: A non-interventional study to determine the hypoglycemia incidence, retrospectively and prospectively, in Turkish T1DM and T2DM patients using a 2-part self-assessment questionnaire. Results: Overall, 2348 patients were enrolled in the Turkey cohort (T1DM = 306 patients, T2DM = 2042 patients). In T1DM patients, 96.8% patients reported hypoglycemic events (Incidence rate [IR]: 68.6 events per patient-year [ppy]), prospectively, while 74.0% patients reported hypoglycemic events (IR: 51.7 events ppy), retrospectively. In T2DM patients, 95.9% patients (IR: 28.3 events ppy) reported hypoglycemic events, prospectively, while 53.6% patients (IR: 23.0 events ppy) reported hypoglycemic events, retrospectively. Nearly all patients reported hypoglycemia during the prospective period. Conclusions: This is a first patient-reported dataset on hypoglycemia in Turkish, insulin-treated diabetes patients. A high incidence of patient-reported hypoglycemia confirms that hypoglycemia remains under-estimated. Hypoglycemia increased healthcare utilization impacting patients' quality of life. Hypoglycemia remains a common side effect with insulin-treatment and strategies to optimize therapy and reduce hypoglycemia occurrence in diabetes patients are required.