Wos İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4807
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Item Evaluation of the Effect of Periodontitis on Quality of Life Using Oral-Dental Health-Related Quality of Life-United Kingdom Scale(2021) Kutsal, Derya; Cetin, Mehtap Bilgin; Durukan, Elif; Bulut, Sule; 0000-0002-8579-5564; 33797852; AAJ-8621-2021Objective The aim of this study was to investigate the impact of periodontitis on oral health-related quality of life (OHQoL) using Oral-Dental Health-Related Quality of Life-United Kingdom (OHRQoL-UK) scale and evaluate the contributing factors. Methods 50 patients with untreated periodontitis and 50 individuals without periodontitis were enrolled in the study. All subjects received detailed periodontal examination. Plaque index (PI), gingival index (GI), probing depth (PD) and clinical attachment level (CAL) measurements were examined. OHRQoL was assessed by the Oral Health Quality of Life-United Kingdom (OHRQoL-UK) scale. Symptoms of periodontitis were monitored by visual analogue scale (VAS). Socio-demographic characteristics, medical history, smoking status, hygiene habits of the participants were recorded. This study is registered at ClinicalTrials.gov as NCT04240014. Results Total OHRQoL-UK scores were 38.24 +/- 6.47 in periodontitis patients and 55.88 +/- 9.38 in non-periodontitis individuals (p < 0.001). The scores of all 4 parameters were significantly lower in patients with periodontitis compared to healthy individuals (p <0.001). Higher PI, GI, PD and CAL values were associated with extensive negative impacts of periodontitis on OHRQoL (p < 0.001). According to the results of linear regression analysis, only periodontitis was found to associate with OHRQoL. Periodontal disease reduces the total quality of life score by 15.087 (ss= -15.087; 95% CI = [(-18.934)-(-11.240)]. Conclusions Individuals with periodontitis has diminished OHRQoL compared to healthy individuals.Item Impact of stage-grade of periodontitis and self-reported symptoms on oral health-related quality of life(2021) Yilmaz, Mediha Nur Nisanci; Bulut, Sule; Bakirarar, Batuhan; 0000-0002-6410-2060; 34478610Objectives The aim of the study was to investigate the impact of stage-grade of periodontitis and self-reported signs and symptoms on oral health-related quality of life. Methods The diagnosis of periodontitis was based on the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. The Turkish version of Oral Health Impact Profile-14 (OHIP-14) was used to assess oral health-related quality of life (OHRQoL) and the participants were requested to state their symptoms associated with periodontal diseases. Results One hundred and sixty-six patients were included in the study with a mean age of 46.54 +/- 9.24 years. The participants with Stage IV and Grade C periodontitis had the highest total OHIP-14 scores (median 20.00 [min.-max, 3.00-35.00] and median 18.50 (min.-max, 0.00-36.00]; respectively). The OHIP-14 scores (mean +/- SD) were significantly associated with the symptoms of bleeding gums (13.64 +/- 9.39), sore gums (18.00 +/- 10.47), swollen gums (17.42 +/- 10.91), bad breath (15.82 +/- 9.44), loose teeth (20.00 +/- 8.66) and drifting teeth (24.56 +/- 8.46). Conclusions This study demonstrates a significant association between OHRQoL and periodontitis. Stage-grade of periodontitis and its symptoms were associated with poor quality of life.Item Relationship of periodontitis and edentulism to angiographically diagnosed coronary artery disease: A cross-sectional study(2020) Cetin, Mehtap Bilgin; Onder, Canan; Orhan, Kaan; Kumbasar, Deniz; Serdar, Muhittin Abdulkadir; Unsal, Elif; 32648271Objective The objective of the study is to examine the connection between oral status and the extent of coronary artery disease (CAD), which is diagnosed by angiography. Background Periodontitis and tooth loss have been linked to atherosclerosis and CAD in previous studies. However, no distinct connection was revealed due to the diversity of the results and the variety of diagnostic methods. To provide a more consistent data pool and stronger evidence, there is a need for studies with standard measurements and diagnostic criteria. Methods 309 patients, who consulted to Ankara University, Faculty of Medicine, Department of Cardiology and had coronary angiography, were enrolled to this study. Individuals were grouped based on their coronary angiography results, as CAD (+) (n = 233) and CAD (-) (n = 76). Studied parameters included cardiovascular risk factors, plaque index (PI), remaining teeth count, bleeding on probing (BOP), and probing pocket depth (PPD). Periapical radiographs were taken from teeth with >= 4 mm PPD. Oral status was categorized as periodontally healthy subjects/patients with gingivitis (Group 1), patients with periodontitis (Group 2), and edentulous subjects (Group 3). Results PI (P < 0.001), PPD (P = 0.001), BOP (P = 0.004), the number of patients with less than 10 teeth (P = 0.014), and edentulism (P = 0.009) were significantly higher in CAD (+) patients, who were mostly older (P < 0.001) and male (P < 0.001). Multivariate logistic regression analysis revealed that Group 2 (odds ratio = 2.48, 95% confidence interval = 1.24-4.95,P = 0.010) and Group 3 (odds ratio = 2.01, 95% confidence interval = 1.14-5.17,P = 0.040) were highly associated with CAD. Two and three stenosed vessels were significantly higher in Groups 2 and 3 compared to Group 1 (P = 0.003). Conclusions It was found that both edentulism and periodontitis were related to CAD.Item Salivary Del-1, IL-17, and LFA-1 levels in periodontal health and disease(2020) Inonu, Elif; Kayis, Seyit Ali; Eskan, Mehmet Akif; Hakki, Sema S.; 32153040Objective and Background Developmental endothelial locus-1 (Del-1), lymphocyte function-associated antigen-1 (LFA-1), and interleukin 17 (IL-17) play critical roles in transendothelial migration of neutrophils in periodontal diseases. The aim of this study was to evaluate salivary Del-1, IL-17, and LFA-1 protein levels in patients with gingivitis (G), chronic periodontitis (CP), and generalized aggressive periodontitis (GAP). Methods A total of 180 systemically healthy, non-smoking patients (45 periodontally healthy (H) and 45 G, 50 CP, and 40 GAP) individuals (between March 2014 and February 2016) were included in this study according to Armitage's (1999) classification. Clinical periodontal parameters, including clinical attachment level, probing depth, plaque index, and gingival index, were recorded. Del-1, IL-17, and LFA-1 protein expression levels were measured in unstimulated saliva samples collected from patients by using enzyme-linked immunosorbent assays.Kruskal-WallisandMann-Whitney U testswere used for multiple comparisons and post hoc statistical analyses, respectively. ROC curve analysis was used to evaluate the sensitivity and specificity of Del-1, IL-17, and LFA-1 in distinguishing periodontal disease from health and gingivitis. Results It was found a high level of IL-17 and a low level of Del-1 in the CP and GAP, as compared to the G and H groups (P < .001). Nevertheless, we found LFA-1 levels were higher in the GAP than in the CP or G groups (P = .00). Consistently, LFA-1 levels were lower in the H and G groups than in the CP and GAP groups (P = .00). The combination of three biomarkers was found as the best predictor yielded exhibited the highest AUC [0.893, 0.845-0.94 (%95 CI)P < .001] in discriminating periodontal disease from health and gingivitis. Conclusion Salivary Del-1, LFA-1, and IL-17 levels might be useful markers for determining the clinical health and disease status of patients with periodontitis. However, further studies that evaluate the level of salivary Del-1, LFA-1, and IL-17 before and after periodontal therapy are required to understand the exact roles of these cytokines during the periodontal healing period.Item Association of probable bruxism with periodontal status: A cross-sectional study in patients seeking periodontal care(2020) Cetin, Metin Bilgin; Sezgin, Yasemin; Maras, Enes; Cebeci, Ilker Ata; 0000-0002-5153-2635; 33368265Objective The goals of this study were to investigate the prevalence of probable bruxism in a group of patients seeking a periodontal care and the association between probable bruxism and periodontal status. Background The results of previous studies evaluating the relationship between bruxism and periodontitis are contradictory. In addition, the relationship between probable bruxism and periodontitis in adults has not been evaluated, yet. Therefore, new studies are required in this field to clarify the relationship between bruxism and periodontitis. Methods Patients seeking periodontal care at a university periodontology unit were considered in this study. Their periodontal diagnosis, number of missing teeth, presence of probable bruxism, and sociodemographic characteristics were recorded. The periodontal status of each study participant was defined according to the latest consensus of the American Association of Periodontology/European Federation of Periodontology, and the 2018 consensus report on the assessment of bruxism was used to evaluate probable bruxism. A multiple logistic regression analysis was performed to determine the effects of bruxism on periodontitis. Results A total of 541 patients (289 females and 252 males, mean age 42.1 +/- 15.9 years) were enrolled in the present study. The prevalence of probable bruxism was 36.6%. Additionally, 40.9% of the study population was diagnosed with periodontitis. The probable bruxers were older (P < 0.001), had a higher number of missing teeth (P < 0.001), and had poor periodontal status (P < 0.001). The multivariate logistic regression analysis suggested that probable bruxism was associated with periodontitis, after adjusting relevant factors (odds ratio: 2.243, 95% CI: 1.465-3.434, P < 0.001). Conclusions It was observed that the prevalence of probable bruxism was 36.6% and probable bruxers showed higher odds of periodontitis. Future studies with prospective randomized design should be conducted to confirm these results among a larger study population.