Wos İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4807
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Item Relationship between primary open angle glaucoma and blood pressure(2020) Yilmaz, Kerem Can; Gungor, Sirel Sur; Ciftci, Orcun; Akman, Ahmet; Muderrisoglu, Haldun; 0000-0002-9635-6313; 0000-0001-8926-9142; 30650042; AAG-8233-2020; W-5233-2018; AAJ-1331-2021Background: Glaucoma is commonly defined as high intra ocular pressure (>= 21 mmHg) with optic neuropathy characterised by progressive loss of retinal ganglion cells which is associated with characteristic structural damage to the optic nerve and visual field loss. There are several studies investigating relation between primary open angle glaucoma (POAG) and both systemic hypertension and especially night hypotension. Our aim was to compare 24-h ambulatory blood pressure variability of patients with glaucoma followed-up in the eye outpatient clinic with that of patients free of glaucoma. Methods: A total of 75 patients were included in the study, 35 in the patient group and 40 in the control group. Both groups were compared for daytime, night-time, and whole day mean systolic and diastolic blood pressure (BP) readings in the ambulatory blood pressure testing. Results: Mean daytime systolic BP of the glaucoma patients was 119.5 +/- 11.6 mmHg, and 128.3 +/- 15.5 mmHg for control group (p = 0.008). The night-time systolic blood pressure, whole day systolic BP, and mean diastolic BP were significantly lower in patients with glaucoma (p = 0.001, p = 0.001, p = 0.028, respectively). In multiple regression analysis, we identified daytime systolic BP, night-time systolic BP, and whole day systolic BP were independent risk factors for developing glaucoma. Conclusion: If the progression of the disease is noticeable in patients with glaucoma at follow-up, night-time hypotension should be ruled out with ambulatory blood pressure and if this is observed medical treatments used by the patients should be reviewed and necessary measures should be taken.Item Blood pressure prediction from speech recordings(2020) Ankishan, HaydarThe aim of this study is to extract new features to show the relationship between speech recordings and blood pressure (BP). For this purpose, a database consisting of / a / vowels with different BP values under the same room and environment conditions is presented to the literature. Convolutional Neural Networks- Regression (CNN-R), Support Vector Machines- Regression (SVMs-R) and Multi Linear Regression (MLR) are used in this study to predict BP with extracted features. From the experiments, the highest accuracy rates of BP prediction from / a / vowel have been obtained based on Systolic BP values with CNNR. In the study, 89.43 % for MLR, 92.15 % for SVM-R and 93.65 % for CNN-R are obtained when ReliefF has been used. When the root mean square errors (RMSE) are considered, the lowest error value is obtained with CNN-R as RMSE = 0.2355. In conclusion, it can be observed that the proposed feature vector (FVx) shows a relationship between BP and the human voices, and in this direction, it can be used as an FVx in a system that will be developed in order to follow the tension of individuals. (C) 2020 Elsevier Ltd. All rights reserved.Item Intraocular pressure in subjects with beta-thalassemia minor(2019) Keskek, Sakir Ozgur; Keskek, Nedime Sahinoglu; Ilgin, Gizem; Sukgen, Emine; 30810618Purpose: Beta-thalassemia minor, a common hereditary blood disorder in Mediterranean countries such as Turkey, is associated with insulin resistance. Insulin resistance, in turn, can be associated with excessively high intraocular pressure and, therefore, intraocular pressure-induced blindness. This study aimed to investigate the intraocular pressure in subjects with beta-thalassemia minor. Methods: We conducted a cross-sectional study comprising of 203 subjects divided into two groups: beta-thalassemia minor (103) and healthy (100). Hemoglobin electrophoresis was performed and complete blood count, blood pressures, serum fasting glucose and insulin levels were measured. All subjects underwent ophthalmological examinations including intraocular pressure measurements. Results: Intraocular pressure in the subjects with beta-thalassemia minor was significantly lower than that in healthy subjects (p=0.007). Additionally, intraocular pressure was inversely correlated with hemoglobin A(2) levels (p=0.001, r=-0.320). Serum insulin and systolic blood pressure were significantly higher in subjects with beta-thalassemia minor (p=0.03, p=0.009, respectively). Conclusion: Subjects with beta-thalassemia minor had lower intraocular pressure than healthy controls, suggesting beta-thalassemia minor may actually protect against high intraocular pressure.Item Impact of Obesity on the Metabolic Control of Type 2 Diabetes: Results of the Turkish Nationwide Survey of Glycemic and Other Metabolic Parameters of Patients with Diabetes Mellitus (TEMD Obesity Study)(2019) Bascil Tutuncu, Neslihan; Bozkus, Yusuf; Bozkirli, Emre; 30893706Background: Obesity is the main obstacle for metabolic control in patients with type 2 diabetes. Turkey has the highest prevalence of obesity and type 2 diabetes in Europe. The effect of obesity on the metabolic control, and the macro-and microvascular complications of patients are not apparent. Objectives: This nationwide survey aimed to investigate the prevalence of overweight and obesity among patients with type 2 diabetes and to search for the impact of obesity on the metabolic control of these patients. We also investigated the independent associates of obesity in patients with type 2 diabetes. Methods: We consecutively enrolled patients who were under follow-up for at least 1 year in 69 tertiary healthcare units in 37 cities. The demographic, anthropometric, and clinical data including medications were recorded. Patients were excluded if they were pregnant, younger than 18 years, had decompensated liver disease, psychiatric disorders interfering with cognition or compliance, had bariatric surgery, or were undergoing renal replacement therapy. Results: Only 10% of patients with type 2 diabetes (n = 4,648) had normal body mass indexes (BMI), while the others were affected by overweight (31%) or obesity (59%). Women had a significantly higher prevalence of obesity (53.4 vs. 40%) and severe obesity (16.6 vs. 3.3%). Significant associations were present between high BMI levels and lower education levels, intake of insulin, antihypertensives and statins, poor metabolic control, or the presence of microvascular complications. Age, gender, level of education, smoking, and physical inactivity were the independent associates of obesity in patients with type 2 diabetes. Conclusion: The TEMD Obesity Study shows that obesity is a major determinant of the poor metabolic control in patients with type 2 diabetes. These results underline the importance of prevention and management of obesity to improve health care in patients with type 2 diabetes. Also, the results point out the independent sociodemographic and clinical associates of obesity, which should be the prior targets to overcome, in the national fight with obesity. (c) 2019 The Author(s) Published by S. Karger AG, Basel