Wos İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4807
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Item Management of Hyperkalemia in Heart Failure(2021) Altay, Hakan; Cavusoglu, Yuksel; Celik, Ahmet; Demir, Serafettin; Kilicarslan, Baris; Nalbantgil, Sanem; Temizhan, Ahmet; Tokgoz, Bulent; Ural, Dilek; Yesilbursa, Dilek; Yildirimturk, Ozlem; Yilmaz, Mehmet Birhan; 34738907Hyperkalemia is a common electrolyte abnormality in heart failure (HF) that can cause potentially life-threatening cardiac arrhythmias and sudden cardiac death. HF patients with diabetes, chronic kidney disease and older age are at higher risk of hyperkalemia. Moreover, hyperkalemia is also often associated with the use of renin-angiotensin-aldosterone system inhibitors (RAASi) including angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, mineralocorticoid receptor antagonists and sacubitril-valsartan. In clinical practice, the occurrence of hyperkalemia is a major concern among the clinicians and often limits RAASi use and/ or lead to dose reduction or discontinuation, thereby reducing their potential benefits for HF. Furthermore, recurrent hyperkalemia is frequent in the long-term and is associated with an increase in hyperkalemia-related hospitalizations. Therefore, management of hyperkalemia has a special importance in HF patients. However, treatment options in chronic management are currently limited. Dietary restriction of potassium is usually ineffective with variable adherence. Sodium polystyrene sulfonate is commonly used, but its effectiveness is uncertain and reported to be associated with intestinal toxicity. New therapeutic options such as potassium binders have been suggested as potentially beneficial agents in the management of hyperkalemia. This document discusses prevalence, predictors and management of hyperkalemia in HF, emphasizing the importance of careful patient selection for medical treatment, uptitration of the doses of RAASi, regular surveillance of potassium and treatment options of hyperkalemia.Item Turkish neonatal society guideline on the neonatal pain and its management(2018) Yiğit, Ş.; Ecevit, A.; Altun Köroğlu, Ö.; 0000-0002-2232-8117; 31236029; AAJ-4616-2021Pain control is an important ethical issue to be considered and constitutes the basis of treatment in premature and term newborns. The inadequacy of pain control in these infants in neonatal intensive care units leads to neurodevelopmental and behavioral problems in the long term. For this reason, it is extremely important to raise awareness of the presence of pain in newborn infants, to reduce invasive procedures applied to infants as much as possible, and to minimize pain with non-pharmacologic or pharmacologic treatments when it is inevitable. © Copyright 2018 by Turkish Pediatric Association.Item Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases(2015) Ozcan, Deren; Seckin, Deniz; Gulec, A.Tulin; Ozen, Ozlem; 0000-0002-7450-6886; 0000-0002-9082-1317; AAQ-6649-2021; AAK-4468-2021Background and Design: Lichen planopilaris (LPP) is a type of cicatricial alopecia characterized by autoreactive lymphocytic destruction of the hair follicle. We aimed to evaluate the demographic, clinical and histopathological features, and treatment outcomes of patients with LPP. Materials and Methods: Medical reports of 25 patients, who have been diagnosed with LPP according to the clinical and histopathological findings between January 2006 and June 2012, were retrospectively reviewed. The transverse and vertical sections of scalp biopsy specimens were re-evaluated by a pathologist, and the findings were noted. Results: Of the 25 patients, 18 were female and 7 were male, the mean age was 49.8 +/- 12.4 years. Eighteen patients had been diagnosed with classic LPP and 7 patients with frontal fibrosing alopecia (FFA). The alopecia has begun in postmenopausal period in 5 patients with FFA. Alopecia was associated with pruritus, pain and/or burning in 19 patients. Extra-scalp involvement was observed in 11 patients. The most common clinical findings were follicular hyperkeratosis (92%), perifollicular erythema (48%), perifollicular lichenoid papules, and positive hair-pull test (44%). Dermatoscopic examination was performed in 14 patients, and most commonly, absence of follicular openings (100%), perifollicular scales (92.9%) and perifollicular erythema (50%) were noted. The most common diagnostic histopathological findings were follicular vacuolar and lichenoid degeneration (88%) and vacuolar and lichenoid interface changes (56%). Twenty-three patients who were started on treatment received topical, intramuscular and intralesional corticosteroids, topical minoxidil, oral tetracycline, cyclosporine A, and hydroxychloroquine either alone or in combination. Progression of alopecia was prevented and the symptoms and/or signs were reduced in 12 (75%) of 16 patients whose follow-up data were available. Conclusion: LPP can be diagnosed accurately through a detailed clinical examination, dermatoscopy and histopathological examination. The symptoms and/or signs can be reduced and progression of the disease can be prevented with treatment.Item Evaluation of Treatment Response by Using a Handheld Dermoscope in Patients with Alopecia Areata(2018) Gulec, A. Tulin; Kose, Ozlem KaradagObjective: Treatment response is variable in patients with alopecia areata, and may not be understood until significant hair growth is obtained. The aim of this study is to determine the potential benefit of handheld dermoscope in evaluating of treatment success in alopecia areata. Methods: Forty-nine patients who were diagnosed with alopecia areata were included in the study. Diagnosis was established clinically, and scalp biopsy was performed in doubtful cases. Dermoscopic examinations were performed by a polarized light and handheld dermoscope with 10-fold magnification. The images were taken by a digital camera with threefold optical zoom. Among 49 patients, 30 of them were followed-up during six months and concluded the study. Results: Of the 30 patients, 12 had a complete response to treatment (group 1), whereas 18 patients did not respond well to treatment or were remained completely responseless (group 2). When the trichoscopic findings were examined pretreatment, only thinning hairs were significantly more frequent in group 1 than group 2. The pre- and posttreatment findings of group 1 was shown that yellow dots, black dots, thinning hairs and broken hairs decreased or disappeared after the treatment, and this difference was statistically significant. In all of the patients in the first group, short terminal hairs were appeared at the end of treatment. Conclusion: According to our study, polarized light handheld dermoscope provides benefit for the evaluation of treatment success in patients with alopecia areata.