Wos İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/11727/4807

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    Pediatric Androgenetic Alopecia: A Retrospective Review Of Clinical Characteristics, Hormonal Assays And Metabolic Syndrome Risk Factors In 23 Patients
    (2022) Ozcan, Deren; https://orcid.org/0000-0002-7450-6886; 35033390; AAQ-6649-2021
    Background: Androgenetic alopecia in the pediatric population is rarely discussed in the literature. Although the prevalence of the metabolic syndrome is increased in patients with early-onset androgenetic alopecia, the presence of metabolic syndrome risk factors in pediatric androgenetic alopecia is unknown. Objective: To evaluate the demographics, medical and family histories, clinical and trichoscopic features, androgenic hormones, and metabolic syndrome risk factors in pediatric androgenetic alopecia. Methods: The medical reports of pediatric patients with androgenetic alopecia were reviewed. Results: The study included 23 patients (12 females and 11 males) with a mean age of 15,3 +/- 2,1 years. Sixteen patients had adolescent androgenetic alopecia and seven, had childhood alopecia. Nine patients reported a family history, all of whom had adolescent androgenetic alopecia. Hyperandrogenism was noted in three patients with adolescent androgenetic alopecia. The most common hair loss pattern was diffuse thinning at the crown with preservation of the frontal hairline which was noted in 10 patients (43.5%), six of whom were males. Fourteen patients (60.9%) had at least one metabolic syndrome risk factor. The most common risk factor was obesity or overweight (47.8%) followed by insulin resistance (21.7%), high fasting blood glucose (13%), high blood pressure (4.4%) and lipid abnormalities (4.4%). Study limitations: Retrospective study; lack of a control group. Conclusion: Pediatric androgenetic alopecia is often associated with metabolic syndrome risk factors. Therefore, androgenetic alopecia in the pediatric population may indicate a future metabolic syndrome which warrants an accurate and prompt diagnosis for early screening and treatment. (C) 2021 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U.
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    Effects of resveratrol on oxidant and antioxidant systems in model of rat metabolic syndrome
    (2014) Ilhan, Nevin; Gungor, Hilal; Ilhan, Ayse Sebnem
    Objective: In recent years, metabolic syndrome, which is a serious health problem, enhancing the effect of oxidative stress and lipid peroxidation, which is a natural antioxidant resveratrol, a polyphenol structure, the use of this area has brought. The present study aimed to evaluate the influence of resveratrol (RSV) treatment on heart, kidney and hepatic tissue malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD) and catalase (CAT) levels in high fructose feeding rats which form an experimental metabolic syndrome model and compared to pre-treatment of metabolic syndrome group and the control group values. Methods: Wistar/albino rats (n=15) were used in the present study. Rats were divided equally into 3 groups as control, created group of metabolic syndrome and metabolic syndrome plus resveratrol treatment. At the end of the experimental period, tissue MDA, NO, SOD and CAT levels were studied manual spectrophotometric methods after homogenization of tissues. Results: The result of the study, a significant increase in heart and liver tissue MDA levels, and heart, kidney, liver tissue NO levels were observed in the metabolic syndrome group compared to the controls (p<0.05), following treatment with resveratrol significantly decreases were observed to be close to the control values. Kidney and liver tissue catalase activity statistically significant decrease in metabolic syndrome group compared to the controls, (p=0.019 and p=0.021, respectively), kidney and liver tissue catalase activity similar to control values after treatment with resveratrol, a significant increase was observed (p=0.011 and p=0.58), but changes in the activity of SOD has not been as significant as catalase (p>0.05). However, hepatic SOD activity of resveratrol treatment group compared with the control group, a significant increase was recorded in the treated group (p=0.011). Conclusion: These results suggest probably antioxidant effects of resveratrol to reduce oxidative stress in the liver and kidney tissue which is an important role in metabolism. Against tissue damage generated by exogenous fructose, resveratrol is effective in preventing tissue damage with a direct or indirect effect shows.