Wos İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4807
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Item Coexistence of restless legs syndrome and multiple sclerosis aggravates anxiety and depression(2022) Sevim, Serhan; Demirkiran, Meltem; Terzi, Murat; Yuceyar, Nur; Tasdelen, Bahar; Idiman, Egemen; Kurtuncu, Murat; Boz, Cavit; Tuncel, Deniz; Karabudak, Rana; Siva, Aksel; Ozcan, Abdulcemal; Neyal, Munife; Goksel Karakurum, Basak; Gazaloglu, Gulcan Baran; Balal, Mehmet; Sen, Sedat; Baklan, Meltem Alkaya; Gunduz, Tuncay; Tuncer, Asli; Uygunoglu, Ugur; 35195221Background: Among the comorbidities that accompany multiple sclerosis (MS), restless legs syndrome (RLS) is one of the most common. Anxiety and depression are common psychological comorbidities that impact the quality of life of patients with MS (PwMS), as well as patients with RLS. Objective: To investigate the psychiatric burden of MS and RLS coexistence, we conducted a nationwide, multicenter and cross-sectional survey. Methods: Participants were assessed by using demographic and clinical parameters along with the Hamilton Anxiety and Hamilton Depression Scales (HAM-A and HAM-D). Results: Out of the 1,068 participants, 173 (16.2%) were found to have RLS [RLS(+)] and 895 (83.8%) did not [RLS(-)]. The mean scores for HAM-A and HAM-D were significantly higher among RLS(+) subjects than among RLS(-) subjects (p<0.001 for all variables). Conclusions: According to our data, the presence of RLS in PwMS may increase the occurrence of both anxiety and depression symptoms. Awareness and treatment of RLS in PwMS could possibly reduce the symptoms of psychiatric comorbidities originating from RLS.Item Evaluation of dry eye disease in newly diagnosed anxiety and depression patients using anterior segment optical coherence tomography(2019) Ulusoy, Mahmut Oguz; Isik-Ulusoy, Selen; Kivanc, Sertac Argun; 31417939Background We aimed to evaluate dry eye diseases (DED) in patients with newly diagnosed depression and anxiety patients. Methods Forty newly diagnosed depression, 35 anxiety patients, and 37 controls without any history of taking psychiatric drugs (or before the beginning of psychiatric medication) and topical ophthalmic drop use, were included in the study. All depression and anxiety diagnoses were performed by an experienced psychiatrist. Beck depression and anxiety tests were used to measure disease severity. Tear film break up time (TBUT), Schirmer's test, Oxford scores and ocular surface disease index (OSDI) were admiinistered to participants. Anterior segment optical coherence tomography was used to measure tear meniscus heights (TMH), tear meniscus depths (TMD) and tear meniscus areas (TMA). Results In anxiety and depression groups, Schirmer's test (mm) (7.24 +/- 6.02, 6.58 +/- 4.9 and 18.79 +/- 4.9 respectively, p < 0.05) and TBUT (s) (5.62 +/- 3.1, 5.6 +/- 3.5 and 13.37 +/- 1.7 respectively, p < 0.05) were significantly lower than control group. In addition, OSDI and Oxford scores were significantly higher than controls. OSDI scores were 28.01 +/- 19, 30.43 +/- 18.49, 14.38 +/- 8.14 respectively (p = 0.002) and Oxford scores were 1.9 +/- 0.7, 2.1 +/- 0.6 and 0.7 +/- 0.4 respectively (p = 0.001). TMD, TMH and TMA values were significantly lower in anxiety and depression groups compared with control groups. Correlations between disease inventory scores and dry eye tests were detected. Conclusions This study showed a relation between DED and newly diagnosed anxiety and depression patients with no history of psychiatric drug use. The presence of correlation between dry eye tests and disease inventory scores strengthens this association. This is an important knowledge that need to be evaluated in these patients before starting psychiatric medication.Item Quality of Life in Panic Disorder: Follow Up Study for 3 Months(2015) Altintas, Ebru; Uguz, Sukru; Levent, Bekir AydinPurpose: Panic Disorder is a common psychiatric condition which is higher risk for substance abuse, suicide attempts and functional disability. It is 2-3 times more common in women and estimated to range from 1,4% to 3,8% of the general population. Studies reported that quality of life in Panic Disorder is negatively affected and overall health (emotional and psyhical health), social activities, risk of unemployment increases. The aim of this study was investigate the affects of quality of life on panic disorder and depression and follow the treatment response after the 3 months. Material and Methods: 22 women and 9 men (total 31) within in age range of 20-73(mean age 40,3 +/- 12,9) diagnosed as Panic Disorder; 27 women and 15 men (total 42) within in age range of 18-57(mean age 33,6 +/- 11,5) diagnosed as Panic Disorder with Agoraphobia; 54 women and 19 men (total 73) within in age 20-69(mean age 38,5 +/- 11,7) diagnosed on Major Depression were included to study. Psychiatric interview were carried out using Structured Clinical Interview for Diagnose(SCID-I), Sociodemographic Data Form, Hamilton Anxiety Scale (HAM-A), Hamilton Depression Scale(HAM-D), Panic and Agoraphobia Scale and Endicott's Work Productivity Scale (EWPS) were applied in 0., 1., 3. months. Results: Quality of life had negatively affected in all of the groups. In this study we found significant impairment in pain, general health, energy, social function, emotional role disability and mental health subgroups of quality of life scale (SF-36) in Depression group than Panic Disorder group. Panic Disorder with Agoraphobia had affected the quality of life worse than comparison with Panic Disorder without Agoraphobia. Conclusion: At the end of the treatment, there were no differences in quality of life between all of the groups statistically.Item Depression, Inflammation, and Social Support in Hemodialysis Patients(2015) Yavuz, Rahman; Yavuz, Demet; Altunoglu, Alparslan; Canoz, Mujdat Batur; Sezer, Siren; Yalcin, Bektas Murat; Demirag, Mehmet DeryaAim: Depression and inflammation are common in patients with end-stage renal disease (ESRD). In our study, we aimed to investigate the relationship between depression, inflammation and social support. Material and Method: Accordingly. 137 patients were enrolled. We used Beck Depression Inventory (BDI) and Multidimensional Scale of Perceived Social Support (MSPSS) and Malnutrition Inflammation Score (MIS) in all patients. Results: BDI, MSPSS and MISS were 15.9 +/- 9.5,60.5 +/- 15.1,7.8 +/- 2.9 respectively. The patients were divided into two groups with respect to BDI scores: patients with depression (BDI score >= 7, n=55, 40.2%) and patients without depression (BDI score< 17.0 =82, 59.8%). In depressive patients, the majority were female (58%) and lived alone (97%). The weekly erythropoietin dose and CRP levels were higher in patients with depression than in patients without depression and this difference did not reach statistical significance (p>0.05). MIS scores were higher in patients with depression (10.5 +/- 1.8) than in patients without depression (6 +/- 2.2) (p<0.001). Patients with depression (57.3 +/- 1 7.91 had lower MSPSS scores than patients without depression (62.7 +/- 12.5) (p<0.05). There was positive correlation between BDI and MIS, while negative correlation was observed between BDI and MSPSS. In the multivariate linear regression analysis (gender, BUN, albumin, MIS and MSPSS), depression was independently associated with MIS (beta=0.60, t=9.9 p<0.001) and MSPSS (beta=-0.37, t=-6.2 p<0.001). Discussion: Hemodialysis patients needed more social and psychological support. They had higher inflammation and lower social support that associated with the presence of depression, although large-scale studies are needed to confirm our results.Item Neuropsychological Changes and Health-related Quality of Life in Patients with Asymptomatic Primary Hyperparathyroidism(2017) Iyidir, Ozlem Turhan; Yilmaz, Banu Aktas; Toruner, Fusun Balos; Degertekin, Ceylan Konca; Kaya, Burhaneddin; Cakir, Nuri; 0000-0001-5305-6807; K-7904-2019Purpose: Data about neuropsychological impairment and health-related quality of life (HRQOL) in patients with asymptomatic primary hyperparathyroidism (APHPT) is limited. We aimed to investigate the HRQOL, neuropyschological impairment, including depression, anxiety in patients with APHPT who have mildly elevated serum calcium (Ca) levels. Material and Method: Thirty-seven patients with APHPT and 37 controls were included. The Beck Depression Inventory (BDI), Spielberger State-Trait Anxiety Inventory (STAI), and the General Health Questionnaire were administered in all patients, HRQOL was investigated using the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36). Results: Serum levels of Ca and parathyroid hormone (PTH) were significantly higher in patients than in controls [(10.92 +/- 0.66 vs. 9.49 +/- 0.66, p= 0.016, and 133 (34-736) vs. 52.95 (25-75.50), p< 0.001), respectively]. The levels of serum vitamin D were lower in patients than in controls [12.85 (4.0-62.50) vs. 20.30 (5.90-55.00), p= 0.041)]. The patient group had higher BDI scores than controls (12.49 +/- 10.34 vs. 7.46 +/- 5.33, p= 0.011). Patients with APHPT showed lower scores in SF-36 mental health (60.55 +/- 20.75 vs. 69.62 +/- 14.31, p= 0.034), SF-36 physical functioning (55.83 +/- 27.30 vs. 75.67 +/- 24.18, p= 0.002), SF-36 social functioning (66.32 +/- 27.69 vs. 82.08 +/- 14.89, p= 0.003), and SF-36 emotional role functioning (42.55 +/- 37.85 vs. 69.30 +/- 35.43, p= 0.003). The patients showed higher STAI-1 scores (39.95 +/- 11.52 vs. 34.70 +/- 8.01, p= 0.026). We observed that STAI-1 score positively correlated with serum Ca level (r= 0.391; p= 0.018); and PTH (r= 0.341; p= 0.042). Discussion: Our study demonstrated that patients with APHPT have more depressive and anxiety symptoms and lower HRQOL. Our results suggest that HRQOL and neuropsychological changes should also be considered during the clinical follow-up of patients with APHT.Item Serum glial cell line-derived neurotrophic factor levels and impulsivity in heroin addiction: a cross-sectional, case-control study of 129 heroin addicts(2018) Kotan, Vahap Ozan; Yuksel, Rabia Nazik; Kotan, Zeynep; Okay, Ihsan Tuncer; Topcuoglu, Canan; Ozkaya, Guven; Bayram, Senol; Goka, ErolOBJECTIVE: Glial cell line-derived neurotrophic factor (GDNF), being a protective of dopaminergic neurons, is reported to modulate addictive behaviours and have a role as a negative regulator for biochemical and behavioural adaptations to drug abuse. We aimed to reveal impulsivity and serum GDNF levels in patients with heroin addiction and investigate their relationships in order to contribute to the understanding of behavioural aspects and biological mechanisms in heroin addiction via this study. METHODS: This study was performed at the Department of Psychiatry of Ankara Numune Training and Research Hospital, Turkey. We recruited 129 heroin-dependent patients and 90 age, sex, and smoking-matched healthy controls with no major psychopathology. Barratt Impulsivity Scale-11, Hospital Anxiety and Depression Scale (HADS) and sociodemographic data form were applied to all participants. Laboratory analysis for serum GDNF levels was performed for each participant's blood sample. RESULTS: Total impulsivity scores and scores of Attentional Impulsivity, Motor Impulsivity, and Unplanned Impulsivity subscales were all higher in heroin addicts compared to the controls. Heroin addicts had also lower serum GDNF levels and lower GDNF levels were associated with high impulsivity and high HADS scores in heroin addicts. CONCLUSION: Decrement in GDNF levels in heroin addiction seems as to be an important data which could be associated with impulsivity, anxiety, and depressive symptoms. GDNF could find a prominent place among the target molecules in the treatment of heroin addiction.Item Factors associated with social anxiety disorder in a group of obese Turkish female patients(2018) Ozsahin, Akath Kursad; Altintas, Ebru; 0000-0001-8844-3946; 0000-0003-2735-4805; 29714460; AAN-3522-2021; G-8832-2015Background/aim: Mental disorders may accompany obesity. This study aims to evaluate the association between social anxiety disorder (SAD) and obesity and the risk factors for SAD in obese female patients. Materials and methods: A total of 114 obese patients and 110 healthy controls were included. The Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), State and Trait Anxiety Inventory (STAI I-II), and Liebowitz Social Anxiety Scale (LSAS) were administered to assess anxiety, depression, and social anxiety levels. Scale scores were analyzed statistically. Results: The rate of SAD in obese female patients was found to be 8.8%. Anxiety, depression, and social anxiety levels were significantly higher in the obesity group compared to the control group (P < 0.05). According to linear regression analyses, a significant association between LSAS anxiety level and age, prior surgery, social support, history of being teased, BDI, and BAI was found. Conclusion: The present study shows that many factors are related to obesity and SAD in obese female patients. The clinical implications of these findings should be considered. Interventions for these factors may help prevent SAD in obese female patients.Item The relationship between internalized stigma and treatment motivation, perceived social support, depression and anxiety levels in opioid use disorder(2018) Akdag, Emine Merve; Kotan, Vahap Ozan; Kose, Samet; Tikir, Baise; Aydemir, Makbule Cigdem; Okay, İhsan Tuncer; Goka, Erol; Ozkaya, GovenOBJECTIVE: This study aims to examine how internalized stigma differs in opioid use disorder (OUD) based on sociodemographic and clinical variables, and to what extent internalized stigma is related to treatment motivation, perceived social support, depression, and anxiety levels. METHODS: One hundred forty-five individuals with OUD included. Sociodemographic and clinical data form, the Internalized Stigma of Mental Illness Scale (ISMI), Treatment Motivation Questionnaire (TMQ), Multidimensional Scale of Perceived Social Support, the Beck Depression Inventory, and the Beck Anxiety Inventory were utilized in the study to collect data. Bivariate and partial correlation coefficients between variables were computed. ISMI and TMQ scores were compared between patients with depressive symptoms and patients without depressive symptoms by using t-test and Mann Whitney U test. RESULTS: Internalized stigma was high among male patients with heroin use disorder. There was a positive correlation between internalized stigma score and treatment motivation, depression, and anxiety levels. On the other hand, there was a negative correlation between internalized stigma score and multidimensional perceived social support. CONCLUSION: Internalized stigma occupies an important place in the treatment of OUD, which occurs with frequent relapses and which is hard to treat. Not only application for treatment but also adherence to treatment and treatment motivation at maintenance phase bestow a complicated relationship with depression and anxiety. In the struggle against internalized stigma, it plays a vital role to mobilize people's social support systems, to educate families on the issue and to get in touch with support units exclusive to heroin users.