Wos İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4807
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Item Protective Effects of Oral Lactobacillus rhamnosus on Liver Steatosis in Rats on High-Fat Diet(2021) Ozbek, Sevan Cetin; Saka, Mendane; Turhan, Nesrin; Istar, Elven Hortac; Mirza, Cenk; Bayraktar, Nilufer; Ok, Mehtap AkcilThe purpose of this study was to investigate the effect of probiotic on fatty liver and metabolic endotoxemia in rats on high-fat diet. The rats were divided into three groups and fed one of the three diets (standard or control diet, high-fat diet, or high-fat + probiotic diet) for 16 weeks. At the end of this period, blood samples of the rats were taken and the liver tissue was removed for histopathology. There was an increase in the activities of both aspartate aminotransferase and alanine aminotransferase in the livers of rats on high-fat diet. However, only the rise in aspartate aminotransferase was blunted by incorporation of probiotics to the high-fat diet. Histopathological examination revealed 62.5% hepatosteatosis in high fat diet group and 12.5% in high-fat + probiotic diet group. In conclusion, the protective effect of probiotic supplement on liver steatosis caused by high-fat diet was histopathologically demonstrated; however, its effect on liver enzymes, inflammatory markers, and metabolic endotoxin was not observed. There is a need for further studies in terms of both dose and strain to recommend the use of probiotics in nonalcoholic fatty liver disease.Item Effects of Nutritional Knowledge of Informal Caregivers on Depression and Metabolic Outcomes of Hemodialysis Patients(2021) Kiziltan, Gul; Turker, Perim Fatma; Beyaz, Esra Koseler; Saka, Mendane; Sayin, Cihat Burak; 0000-0001-8287-6572; 34459351; J-3707-2015Chronic renal failure (CRF) makes significant changes in the life of patients and their families. A good family support has a positive effect on successful patients' adaptation to the treatment and compliance with dietary regimen. This study aimed to examine the effects of nutritional knowledge of informal caregivers on depression and metabolic outcomes of hemodialysis patients. This was a cross-sectional study conducted at Baskent University Hemodialysis Center with 116 hemodialysis patients and their informal caregivers. Findings revealed that the caregivers who were the couple of the patients had the highest nutritional knowledge level than the other caregivers (p < .05). The postgraduate caregivers were more likely to have high nutritional knowledge level than the others (p < .05). The inflammation marker of the patients was significantly lower in the group of caregivers with higher level (T3 group) of nutritional knowledge than the others (p < .05). The mean CES-D scores were also more likely to be low in T3 group than in the others (p < .05). These findings highlight that the nutritional knowledge of caregivers of hemodialysis patients may have an additional benefit on patients' nutritional management and metabolic outcomes.Item Effects of reproductive and sociodemographic factors on obesity in Turkish women: a pilot study(2019) Bayram, Sinem; Koseler, Esra; Kiziltan, Gul; Ok, Mebtap Akcil; Yesil, Esen; Kose, Beril; Ozdemir, Merve; Muftuoglu, Selen; Saka, Mendane; Aksoydan, Emine; Tayfur, Muhittin; Turker, Perim Fatma; Ercan, Aydan; 0000-0003-1569-7747; 0000-0002-4254-3711; AAF-4491-2021; AAG-6763-2020Background and aim: Obesity has become a global epidemic. The current research aimed to determine sociodemographic and reproductive predictors of obesity among Turkish women. Materials and methods: Eligible subjects (n:833) were 40-64 years-old women living in Turkey. A questionnaire consisted of questions about sociodemographic and reproductive factors and the International Physical Activity Questionnaire were applied to participants by face to face interviews. Multivariate logistic regression examined the risk of being obese with a range of sociodemographic and reproductive factors. All analyses were performed with SPSS software (version 17.0; SPSS, Chicago, Ill., USA). Results: The mean BMI of women aged 51-64 years was 30.59 +/- 6.35 kg/m(2). After adjustments for all other variables, increased obesity risk remained significant in women who had two children, housewifes, minimum active ones, ex smokers and had less than high school education. For multiple regression analysis sociodemographic factors from the bivariate analyses were entered, controlling for menarch age, menopausal age, hormone RT, parity, number of stillbirth, abortion. There was significant association between family income, occupation, education and BMI. Conclusion. In summary these findings showed comparable patterns of association of sociodemographic and reproductive factors with obesity in Turkey. Specific healthy lifestyle counseling is important for decreasing obesity in childbearing age women.Item The effects of enteral supplementation of glutamine and arginine in lipopolysaccharide (LPS) induced sepsis(2019) Bakir, Binnur Okan; Oztezcan, Serdar; Saka, Mendane; Karalti, Iskender; Ozkan, Ferda; Ok, Mehtap Akcil; AAZ-8170-2020Sepsis is the leading cause for death in critically ill patients. While the exact mechanisms are not clear, multiple organ dysfunction syndrome induced by sepsis might cause mitochondrial dysfunction. Spesific nutrients may help regulating immunological and inflammatory responses. Glutamine and arginine amino acids have both important roles in growth, tissue repair, cell renewal and collagen synthesis. There are different results of studies with immunmodulatory nutrients in critically ill patients such, they have no effect on mortality or decrease sepsis incidance. The aim of this study is to evaluate the effects of enteral supplementation of glutamine, arginine and glutamine and arginine combination in lipopolysaccharide (LPS) induced sepsis. Twenty eight male Sprague Dawley rats were randomly divided into four groups: Glutamine, Arginine, Glutamine + Arginine and Control. Glutamine group received 500 mg/kg/day glutamine, Arginine group recieved 500 mg/kg/day arginine, Glutamine + Arginine group received 250 mg/kg/day glutamine and 250 mg/kg/day arginine containing suspension. Rats were fed for 10 days and 3 mg/kg LPS was implemented. 24 hours later, all rats were sacrified. C-Reactive Protein (CRP), Interleukin (IL)-1 beta, IL-6, Tumor Necrosis Factor-alpha(TNF-alpha), Aspartat aminotransferase (AST) and Alanine aminotransferase(ALT) levels were studied, livers were examined histopathologically. Serum TNF-alpha levels were significantly lower in Glutamine + Arginine group in comparison with Control group. Liver histopathology analysis showed that apsis, hepatocyte damage, kupffer cell proliferation and portal inflammation were more frequent and severe in control group than all groups. These results revealed that enteral supply of glutamine, arginine and their combination have positive effects on liver damage and inflammation.Item The relationship between quality of life and anthropometric measurements in premenopausal and postmenopausal among turkish women(2019) Kose, Beril; Yesil, Esen; Turker, Perim Fatma; Ok, Mehtap Akcil; Bayram, Sinem; Beyaz, Esra Koseler; Ozdemir, Merve; Muftuoglu, Selen; Tayfur, Muhittin; Aksoydan, Emine; Ercan, Aydan; Saka, Mendane; Kiziltan, Gul; 0000-0003-1569-7747; AAG-6763-2020The aim of this work was to investigate whether there is a relationship between anthropometric measurements and quality of life scores during pre and postmenopouse period. A descriptive study was carried out on 1276 women (40-64 years). Demographic features, socioeconomic attributes and anthropometric measurements were considered using a validated instrument the Turkish version of the EUROHIS (WHOQOL-8.Tr) was performed. Significant body mass index (BMI), height, waist circumference, hip circumference, waist/ height ratio differences were determined by comparing pre and postmenopausal women (p <0.05). Significantly lower quality of life scores were observed in premenopausal women (p<0.05). BMI was determined as significant predictor for quality of life for each group. The number of pregnancy, number of live birth, number of stillbirth and waist/height ratio did not show significant association with quality of life. The age of first pregnancy was stated as significant predictor for quality of life just for premenopausal women. In our study, quality of life increased as the BMI decreased in pre and postmenopausal women. Significantly lower WHO-8 EUROHIS scores were observed in premenopausal women. The age of first pregnancy affected the life quality in positive way in just premenopausal women. As the age of first pregnancy increased, quality of life score increased in premenopausal women.