Wos İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4807
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Item The Correlation Of Uric Acid Levels With Biochemical Parameters And Dietary Factors In Individuals With Asymptomatic Hyperuricemia And Gouty Arthritis(2022) Turker, Perim Fatma; Hoca, Mustafa; Ozduran, Gulsen; Ok, Mehtap Akcil; Celebi, Merve Demir; 35300582Diet may play an important role in the development of asymptomatic hyperuricemia (ASH) and gouty arthritis (GOUT). However, the association between dietary factors and hyperuricemia remains unclear. Serum uric acid levels are affected by dietary factors. This study aimed to evaluate the correlation of uric acid levels with biochemical parameters and dietary factors in individuals with ASH and GOUT. This study was conducted in 145 individuals with ASH and GOUT. General characteristics of individuals were collected via face-to-face interviews. Food frequency questionnaire was used to obtain energy, macro- and micronutrients intakes. Biochemical parameters were obtained from patient files. The incidence of gout was higher in men comparing to women. Individuals in the GOUT group consumed more alcohol and higher serum levels of vitamin B-12, C-reactive protein (CRP), triglyceride, and uric acid. Individuals in the GOUT group had higher intakes of energy, protein, carbohydrate, fat, fructose, vitamin C, and vitamin B-12. Triglyceride, uric acid, CRP, vitamin B-12, and homeostatic model assessment of insulin resistance were found to be affected by high uric acid levels. Dietary factors can pose a risk for health problems in addition to GOUT and ASH, such as cardiovascular disease, diabetes, and obesity.Item Radiographic Ischial Enthesopathy in Patients with Psoriatic Arthritis(2022) Bitik, Berivan; Dalgic, Gunay Sahin; Kanbur, Aysenur Yalcintas; Ok, Mehtap Akcil; Yucel, Ahmet Eftal; https://orcid.org/0000-0001-5803-915X; AAI-9195-2021Background To investigate the prevalence of radiographic ischial entheseal lesions in patients with psoriatic arthritis (PsA) compared to patients with rheumatoid arthritis (RA). Patients and Methods Thirty-eight patients with PsA and 46 patients with RA were included. Anteroposterior radiographs of the pelvis and lateral foot were evaluated for entheseal lesions. The following entheseal sites were reviewed: os ischium, bilateral Achilles tendon and inferior calcaneus. Abnormalities such as cortical erosions and enthesophytes (irregular bony proliferation) were recorded. Results The frequency of enthesopathic changes in the ischial region was found to be statistically significantly higher in PsA patients compared with RA patients (50 and 28.3%, respectively, p=0.04). Enthesopathic changes of the calcaneus and Achilles tendon also occurred more frequently in PsA patients than in RA patients. Conclusion Radiographic entheseal lesions in the ischial region are more prevalent in PsA patients compared with RA patients with symptoms in that region. Furthermore, such enthesopathic changes in the ischium are observed as frequently as changes in the Achilles tendon. These findings regarding structural entheseal lesions in the pelvic region contribute to the knowledge of entheseal involvement in PsA.Item Antibacterial Resistance in Lower Respiratory Tract Bacterial Pathogens: A Multicenter Analysis from Turkey(2021) Guclu, Aylin Uskudar; Kocak, Aylin Altay; Ok, Mehtap Akcil; Tutluoglu, Bulent; Basustaoglu, Ahmet; 0000-0002-1872-028X; 0000-0002-0451-0142; 33690209; AAU-6196-2020; AAI-8012-2021Introduction: This study aimed to evaluate the etiology of lower respiratory tract infections (LRTIs) and their antibiotic resistance. Methodology: Bacterial culture results of LRT samples from 17 hospitals between 2016-2019 were included in the study. All isolates were identified and AST were performed by automated microbiology systems. AST was performed according to EUCAST. Results: Non-duplicate 30,051 (26,890 HA and 3156 CA) isolates detected as causative pathogen. LRTIs are caused by 85.1% Gram-negative bacterial pathogens and 14.9% Gram-positive. The most common isolates among HA pathogens were Acinetobacter spp. (27.4%), P. aeruginosa (22.2%), K. pneumoniae (17.9%); among CA pathogen S. pneumoniae (19.9%), P. aeruginosa (18.9%), H. influenzae (14.6%). ESBL rate was 62.5% in K. penumoniae; 53.1% in E.coli; 19.1% in Klebsiella spp; 13.9% in Enterobacter spp.; 8.6% in Proteus spp.; 6.3% in Citrobacter spp.; and 4.3% in Serratia spp. Resistance rates to carbapenems and colistin were 92.8% and 12.8% in A baumannii, 39.8% and 7.5% in P. aeruginosa, 47.3% and 18.5% in K. penumoniae. Among staphylococci, 27.3% of S. aureus and 82.4% of CoNS were methicillin resistant. 7.6% of E.faecium and 0.9% of E. faecalis were vancomycin resistant. Linezolid resistant S. aureus, CoNS, E. faecalis and E. faecium rates were 0.3%, 2.9%, 0.0% and 4.6%. Inducible clindamycin resistant rate was 17.2% in S. aureus 38.2% in CoNS. Non-susceptible S. pneumoniae isolate rate to penicillin was 37.0%. 6.5% of S. maltophilia and 4.4% of B. cepacia isolates were resistant to trimethoprim/sulfamethoxazole. Conclusions: Antibiotic resistance was mainly observed among A. baumannii and K. pneumoniae and continuous surveillance of antimicrobial resistance patterns in the management of LRTIs is important.Item The impact of occupational education on obesity prejudice of university students(2021) Ercan, Aydan; Altun, Simay; Ok, Mehtap AkcilObjective: The aim of this study was to investigate the obesity related prejudices and negative attitudes of university students who study in health and non-health fields. Subjective and Methods: This is a descriptive study conducted to determine the obesity prejudice levels of students studying in health and social fields. A total of 732 students (577 females, 155 males) of different faculties of a university participated in the study voluntarily. The Prejudice was measured with Obesity Prejudice Scale (OPS). Analysis of Variance and Covariance were used to investigate relationships between of OPS scores and factors. Results: A total of 732 students, 577 (78.8%) females and 155 (21.2%) males, participated in this study, which was conducted to determine obesity prejudices of university students. According to their mean OPS scores, 18.4% of the students were found to be unprejudiced, 55.1% prone to be prejudiced, and 26.5% prejudiced. The intragroup comparisons of mean OPS scores of health and social field students indicated that the differences between the prejudiced and the unprejudiced were statistically highly significant (p<0.0001). Conclusions: In order to prevent the development of internalized obesity prejudices emerging as a result of prejudices against obese individuals in the society and their stigmatization, this problem must be solved at an early age, especially during university education. It is necessary that state policies should be established to monitor the attitudes of individuals towards obesity, people should be educated and supervised on this subject, and that further research representing the society on this topic should be conducted.Item Protective Effects of Oral Lactobacillus rhamnosus on Liver Steatosis in Rats on High-Fat Diet(2021) Ozbek, Sevan Cetin; Saka, Mendane; Turhan, Nesrin; Istar, Elven Hortac; Mirza, Cenk; Bayraktar, Nilufer; Ok, Mehtap AkcilThe purpose of this study was to investigate the effect of probiotic on fatty liver and metabolic endotoxemia in rats on high-fat diet. The rats were divided into three groups and fed one of the three diets (standard or control diet, high-fat diet, or high-fat + probiotic diet) for 16 weeks. At the end of this period, blood samples of the rats were taken and the liver tissue was removed for histopathology. There was an increase in the activities of both aspartate aminotransferase and alanine aminotransferase in the livers of rats on high-fat diet. However, only the rise in aspartate aminotransferase was blunted by incorporation of probiotics to the high-fat diet. Histopathological examination revealed 62.5% hepatosteatosis in high fat diet group and 12.5% in high-fat + probiotic diet group. In conclusion, the protective effect of probiotic supplement on liver steatosis caused by high-fat diet was histopathologically demonstrated; however, its effect on liver enzymes, inflammatory markers, and metabolic endotoxin was not observed. There is a need for further studies in terms of both dose and strain to recommend the use of probiotics in nonalcoholic fatty liver disease.Item Triglycerides/high-density lipoprotein cholesterol is a predictor similar to the triglyceride-glucose index for the diagnosis of metabolic syndrome using International Diabetes Federation criteria of insulin resistance in obese adolescents: a cross-sectional study(2020) Cin, Nazli Nur Asian; Yardimci, Hulya; Koc, Nevra; Ucakturk, Seyit Ahmet; Ok, Mehtap Akcil; 32447329; AAZ-8170-2020Objectives: Metabolic syndrome (MS) is a fatal endocrinopathy that begins with insulin resistance (IR) and causes abdominal obesity, glucose intolerance, or systemic disorders. This study was aimed to determine the cut-off values for the triglyceride (TG)/high-density lipoprotein cholesterol (TG/HDL-C) ratio, the TG glucose (TyG) index and homeostasis model assessment (HOMA-IR) for the diagnosis of MS in obese adolescents, and to compare which of the three indexes would offer a more accurate approach to diagnosis. Methods: The study population comprised 1,171 obese adolescents (639 females and 532 males aged 10-16 years, Body Mass Index (BMI)>=95th percentile). Indirect measures of IR screening for MS were the TG/HDL ratio, TyG index, and HOMA-IR. The cut-off values of the TG/HDL ratio, TyG index, and HOMA-IR were obtained from receiver operation characteristic (ROC) curves. Results: HOMA-IR had a significant positive correlation with the TyG index (r=0.352, p<0.001) and TG/HDL-C (r=0.291, p<.001). The TyG index and TG/HDL-C showed a strong positive correlation (r=0.901, p<0.001). The TG/HDL-C ratio showed a larger ROC Area under Curve (AUC=0.849) than HOMA-IR index (AUC=0.689), but as a predictor similar to TyG index (AUC=0.833) when screening for MS. The cut-off values for MS were as follows: TG/HDL-C ratio>2.16 (sensitivity: 88.8%; specificity: 49.7%), TyG index>8.50 (sensitivity: 85.6%; specificity: 57.0%) and HOMA-IR>2.52 (sensitivity: 83.2%; specificity: 40.4%). Conclusions: Both the TyG index and TG/HDL-C ratio are better markers than HOMA-IR to determine the risk of metabolic syndrome according to IDF criteria. Besides, the TyG index and TG/HDL-C ratio have similar differentiating powers to determine this risk in obese Turkish adolescents.Item The effects of enteral supplementation of glutamine and arginine in lipopolysaccharide (LPS) induced sepsis(2019) Bakir, Binnur Okan; Oztezcan, Serdar; Saka, Mendane; Karalti, Iskender; Ozkan, Ferda; Ok, Mehtap Akcil; AAZ-8170-2020Sepsis is the leading cause for death in critically ill patients. While the exact mechanisms are not clear, multiple organ dysfunction syndrome induced by sepsis might cause mitochondrial dysfunction. Spesific nutrients may help regulating immunological and inflammatory responses. Glutamine and arginine amino acids have both important roles in growth, tissue repair, cell renewal and collagen synthesis. There are different results of studies with immunmodulatory nutrients in critically ill patients such, they have no effect on mortality or decrease sepsis incidance. The aim of this study is to evaluate the effects of enteral supplementation of glutamine, arginine and glutamine and arginine combination in lipopolysaccharide (LPS) induced sepsis. Twenty eight male Sprague Dawley rats were randomly divided into four groups: Glutamine, Arginine, Glutamine + Arginine and Control. Glutamine group received 500 mg/kg/day glutamine, Arginine group recieved 500 mg/kg/day arginine, Glutamine + Arginine group received 250 mg/kg/day glutamine and 250 mg/kg/day arginine containing suspension. Rats were fed for 10 days and 3 mg/kg LPS was implemented. 24 hours later, all rats were sacrified. C-Reactive Protein (CRP), Interleukin (IL)-1 beta, IL-6, Tumor Necrosis Factor-alpha(TNF-alpha), Aspartat aminotransferase (AST) and Alanine aminotransferase(ALT) levels were studied, livers were examined histopathologically. Serum TNF-alpha levels were significantly lower in Glutamine + Arginine group in comparison with Control group. Liver histopathology analysis showed that apsis, hepatocyte damage, kupffer cell proliferation and portal inflammation were more frequent and severe in control group than all groups. These results revealed that enteral supply of glutamine, arginine and their combination have positive effects on liver damage and inflammation.Item Effect of weight loss diets on biochemical parameters and anthropometric measurements in prolactinoma patients(2019) Yesil, Esen; Kiziltan, Gul; Anil, Cuneyd; Ok, Mehtap Akcil; Bayraktar, Nilufer; AAZ-8170-2020Background: The aims of this study were to determine the effect of weight loss on biochemical parameters and anthropometric measurements in prolactinoma patients and to evaluate the effectiveness of weight loss diet along with medical treatment. Methods: Twenty-two patients with prolactinoma were divided into two groups and one of the groups was applied weight loss diet (diet group) while the other group was diet free (control group). Each participant was interviewed using a structured questionnaire. The biochemical parameters (fasting plasma glucose, fasting plasma insulin, prolactin, leptin, TSH, T4, cortisol, HbA1c, AST, ALT and blood lipids) of participants were analyzed and anthropometric measurements were taken. Results: There was a significant change in mean BMI after treatment in diet group (p=0.000). The mean level of serum prolactin decreased from 45.1 +/- 31.63 ng/dL at baseline to 12.6 +/- 8.19 ng/dL after three months in diet group (p=0.006). Despite there being no statistically significant difference between diet and control group in terms of baseline level of prolactin measurement (p=0.800), statistically significant difference between the two groups in terms of final level of prolactin measurement (p=0.027) was observed. There was a significant change in mean level of leptin after treatment in diet group (p=0.001). Conclusions: In addition to medical treatment, weight loss diets sped up the healing process for hyperprolactinemia and the reduction in body weight had positive effects on the metabolic profiles of prolactinoma patients.Item The relationship between quality of life and anthropometric measurements in premenopausal and postmenopausal among turkish women(2019) Kose, Beril; Yesil, Esen; Turker, Perim Fatma; Ok, Mehtap Akcil; Bayram, Sinem; Beyaz, Esra Koseler; Ozdemir, Merve; Muftuoglu, Selen; Tayfur, Muhittin; Aksoydan, Emine; Ercan, Aydan; Saka, Mendane; Kiziltan, Gul; 0000-0003-1569-7747; AAG-6763-2020The aim of this work was to investigate whether there is a relationship between anthropometric measurements and quality of life scores during pre and postmenopouse period. A descriptive study was carried out on 1276 women (40-64 years). Demographic features, socioeconomic attributes and anthropometric measurements were considered using a validated instrument the Turkish version of the EUROHIS (WHOQOL-8.Tr) was performed. Significant body mass index (BMI), height, waist circumference, hip circumference, waist/ height ratio differences were determined by comparing pre and postmenopausal women (p <0.05). Significantly lower quality of life scores were observed in premenopausal women (p<0.05). BMI was determined as significant predictor for quality of life for each group. The number of pregnancy, number of live birth, number of stillbirth and waist/height ratio did not show significant association with quality of life. The age of first pregnancy was stated as significant predictor for quality of life just for premenopausal women. In our study, quality of life increased as the BMI decreased in pre and postmenopausal women. Significantly lower WHO-8 EUROHIS scores were observed in premenopausal women. The age of first pregnancy affected the life quality in positive way in just premenopausal women. As the age of first pregnancy increased, quality of life score increased in premenopausal women.Item A content analysis of food advertising on Turkish television(2016) Ok, Mehtap Akcil; Ercan, Aydan; Kaya, Fatih Suleyman; 26135584; AAZ-8170-2020The aim of this study was to conduct a comprehensive content analysis of Television (TV) food advertising and compare various food advertisements on free-to-air Turkish national TV channels by broadcast time (duration) and frequency over the period of aweek (19-25 April 2012). TV food advertisements were the unit of content analysis in this study. Each advertisement identified as promoting a food product was analysed for content; non-food advertisements were not analysed, although they were counted as a proportion of the advertisements aired. We recorded all programmes for 4 h each per day (7 p.m.-11 p.m.), totalling 84 h. Five types of food-related advertisements were identified (basic foods, junk foods, meat products, beverages and fast food), and six types of non-food advertisements. The Student t-test and ANOVA were used to compare the mean broadcast time of all prime time advertising for the two groups. The mean broadcast times for prime time, non-food advertisements showed a statistically significant difference (p < 0.05). This difference is related to the prime time period 7 p.m.-8p.m. being considered dinner time for most Turkish families. Additionally, the number and broadcast times of beverage advertisements increased during this time period, while the broadcast time per beverage advertisement decreased (ratio = 20.8 s per ads). As a result, TV food advertising increased not only during dinner time but also in overall broadcast time (per advertisement). These findings may be useful for explaining how advertising can negatively influence food choices, thereby increasing public awareness of the need for health messages targeting obesity.