Wos İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4807
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Item Improvement of Work Productivity and Quality of Life with Anti-Tumor Necrosis Factor Treatment Used in Crohn's Disease in Routine Clinical Practice in Turkey(2022) Toruner, Murat; Basaranoglu, Metin; Atug, Ozlen; Senturk, Omer; Akyuz, Filiz; Cekic, Cem; Hamzaoglu, Hulya Over; Tekin, Fatih; Sezgin, Orhan; Akpinar, Hale; Celik, Aykut Ferhat; Tezel, Ahmet; Gokturk, Huseyin Savas; Kav, Taylan; 35678798Background: Patients with Crohn's disease experience major deterioration in work productivity and quality of life. We aimed to provide the long-term effects of anti-tumor necrosis factor agents on work productivity and activity impairment and quality of life in patients with Crohn's disease using the Inflammatory Bowel Disease Questionnaire and the Short-Form Health Survey-36. Methods: Patients with Crohn's disease and initiated an anti-tumor necrosis factor treatment were included and followed up for 12 months in this observational study. Results: A total of 106 patients were included in this study, and 64.2% of the patients were males. Mean [+/- standard deviation] age was 36.8 [+/- 10.9] years. At baseline, mostly perianal fistulas [65.7%] were observed [n = 23]. Intestinal stenosis was detected in 34.9% of the patients [n = 37], and most of the stenosis was located in the ileum [70.6%] followed by the colon [20.6%]. Extraintestinal symptoms were observed in 24 patients [22.6%]. Most frequent extraintestinal symptom was arthritis with 71.4% [n = 15]. Mean time from first symptom to initiation of anti-tumor necrosis factor treatment was 6.3 [+/- 5.0] years. Improvements in work productivity and activity impairment scores throughout 12 months were -24.1% [P =.003] for work time missed, -18.0% [P =.006] for impairment at work, -8.5% [P =.160] for overall work impairment, and -17.0% [P <.001] for daily activity impairment. Similarly, significant improvements [P <.001] were detected in all components of the Inflammatory Bowel Disease Questionnaire when compared to baseline. Statistically significant improvements [P <.05] were detected for all components of Short-Form Health Survey-36 except for mental health [P =.095]. Conclusion: Our study indicates the significant improvement in work productivity and activity impairment and quality of life of patients with Crohn's disease who receive long-term anti-tumor necrosis factor treatment.Item Etiology of Cirrhosis in Turkey: A National Cohort Study(2021) Yildirim, Abdullah Emre; Ucbilek, Enver; Oruncu, M. Berk; Turan, Ilker; Demir, Mehmet; Koksal, Aydin; Uyanikoglu, Ahmet; Yilmaz, Nimet; Akarsu, Mesut; Tozlu, Mukaddes; Avcioglu, Ufuk; Haktaniyan, Busra; Aladag, Murat; Yolacan, Ramazan; Toka, Bilal; Kefeli, Ayse; Ormeci, Asli Ciftcibasi; Haciyev, Ferid; Balci, Hatice Rizaoglu; Yurci, Mustafa Alper; Balaban, Hatice Yasemin; Fidan, Sami; Gunduz, Feyza; Gencdal, Genco; Simsek, Cem; Ebik, Berat; Cavus, Bilger; Karatay, Eylem; Sezgin, Gulten Can; Yaras, Serkan; Karabulut, Umit; Gokturk, Huseyin Savas; Uzel, Ali; Ekin, Nazim; Barutcu, Sezgin; Cosar, Arif Mansur; Keklikkiran, Caglayan; Batu, Kerim Deniz; Alkim, Huseyin; Acar, Sencan; Yogun, Yasar; Harputluoglu, Murat; Yalcin, Kendal; Gunsar, Fulya; Sezgin, Orhan; Akarca, Ulus; Kaymakoglu, Sabahattin; Karasu, Abdullah Zeki; Ozdogan, Osman Cavit; Idilman, RamazanItem Real-world efficacy and safety of Ledipasvir plus Sofosbuvir and Ombitasvir/Paritaprevir/Ritonavir +/- Dasabuvir combination therapies for chronic hepatitis C: A Turkish experience(2020) Gokturk, Huseyin Savas; 33626001Background/Aims: This study aimed to evaluate the real-life efficacy and tolerability of direct-acting antiviral treatments for patients with chronic hepatitis C (CHC) with/without cirrhosis in the Turkish population. Material and Methods: A total of 4,352 patients with CHC from 36 different institutions in Turkey were enrolled. They received ledipasvir (LDV) and sofosbuvir (SOF)+/- ribavirin (RBV) ombitasvir/paritaprevir/ritonavir +/- dasabuvir (PrOD)+/- RBV for 12 or 24 weeks. Sustained virologic response (SVR) rates, factors affecting SVR, safety profile, and hepatocellular cancer (HCC) occurrence were analyzed. Results: SVR12 was achieved in 92.8% of the patients (4,040/4,352) according to intention-to-treat and in 98.3% of the patients (4,040/4,108) according to per-protocol analysis. The SVR12 rates were similar between the treatment regimens (97.2%-100%) and genotypes (95.6%-100%). Patients achieving SVR showed a significant decrease in the mean serum alanine transaminase (ALT) levels (50.90 +/- 54.60 U/L to 17.00 +/- 14.50 U/L) and model for end-stage liver disease (MELD) scores (7.51 +/- 4.54 to 7.32 +/- 3.40) (p<0.05). Of the patients, 2 were diagnosed with HCC during the treatment and 14 were diagnosed with HCC 37.0 +/- 16.0 weeks post-treatment. Higher initial MELD score (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.22-2.38; p=0.023]), higher hepatitis C virus (HCV) RNA levels (OR: 1.44, 95% CI: 1.31-2.28; p=0.038), and higher serum ALT levels (OR: 1.38, 95% CI: 1.21-1.83; p=0.042) were associated with poor SVR12. The most common adverse events were fatigue (12.6%), pruritis (7.3%), increased serum ALT (4.7%) and bilirubin (3.8%) levels, and anemia (3.1%). Conclusion: LDV/SOF or PrOD +/- RBV were effective and tolerable treatments for patients with CHC and with or without advanced liver disease before and after liver transplantation. Although HCV eradication improves the liver function, there is a risk of developing HCC.Item Gastric Polyps: A Retrospective Analysis of Endoscopic Biopsies: A Single Center Study in Central Anatolia(2019) Erinanc, Hilal; Unler, Gulhan Kanat; Gokturk, Huseyin Savas; Ozgur, Gulsum TekeObjective: Gastric polyps accounts for %6 of gastrointestinal endoscopy. Geographical differences occur in the prevalence of them. We aimed to determine the spectrum of gastric polyps. Matherial and method: Data including demographics, medical history and histological characteristics of polyps and Helicobacter pylori were obtained retrospectively. Results: Of the 24568 endoscopies performed, 184 patients were identified as having gastric polyps. The most frequently encountered were hyperplastic polyps (62%), followed by fundic gland polyps (19,3%) and adenomatous polyps (3, 8%). The corpus (36,4 %) was the most common site and the antrum (25%) was the second. Female patients were more affected than male patients (64,7%). Majority of the polyps (88%) were smaller than 1 cm in diameter. The mean age was 62,10+13,4 (range:30-90) years. Fundic gland polyps were observed at younger age (mean age: 56,58) compared to other gastric polyps. Intestinal metaplasia was more frequently encountered in hyperplastic polyps than in fundic gland polyps. Conclusion: In this study, hyperplastic polyps are the most common in our population however there was no association between the hyperplastic polyps and H. pylori infection. H. pylori infection ratio was similar in both hyperplastic polyps and fundic gland polyps however all of the patient have chronic gastritis. This findings suggest chronic gastritis also play role in hyperplastic polyps development. The study also showed that H. Pylori infection is still common in our country and further studies need to find efficacy of H.pylori treatment.Item A Rare Cause of Acute Dysphagia: Abscess of the Base of the Tongue(2015) Ozgur, Gulsum Teke; Akdogan, Mehmet Volkan; Unler, Gulhan Kanat; Gokturk, Huseyin Savas; 25802771Dysphagia represents a difficulty in passage of solid or liquid foods from the oral cavity into the stomach and is considered as an alarm symptom of gastrointestinal system. It often indicates an organic disease and needs to be explained. In this paper, a case of 61-year-old manwith posterior tongue abscess is presented.Item A Rare Type of Eosinophilic Gastroenteritis: Eosinophilic Ascites(2015) Unler, Gulhan Kanat; Ozgur, Gulsum Teke; Erinanc, Ozgur Hilal; Gokturk, Huseyin SavasEosinophilic gastrointestinal diseases are a group of inflammatory disorders characterized by signs and symptoms associated with eosinophil infiltration of the gastrointestinal tissues with the absence of any secondary cause of eosinophilia such as parasitic infection, vasculitis and malignancy. Eosinophilic gastrointestinal diseases are rare and eosinophilic ascite is probably the least common and least reported form. We reported a case of 24-year old women presented with eosinophilic ascites and we want to point out a rare cause of ascites that can be managed appropriately.Item Leser-Trelat sign or Leser-Trelat syndrome?(2016) Gokturk, Huseyin Savas; Unler, Gulhan Kanat; Dursun, RecepItem Is there any association between colonic polyps and gastric intestinal metaplasia?(2016) Unler, Gulhan Kanat; Ozgur, Gulsum Teke; Gokturk, Huseyin Savas; Korkmaz, Huseyin; Erinanc, Ozgur Hilal; 27210777Background/Aims: Chronic gastritis progression is a multistep process of atrophy, intestinal metaplasia (IM), and dysplasia, which may lead to invasive carcinoma. In this study, we identified an association of colonic polyps with gastric IM in patients undergoing colonoscopy. Materials and Methods: This retrospective case-control, cross-sectional study was conducted in a tertiary-care institution in Turkey. Pathology and endoscopy reports were reviewed. The study group comprised 400 patients with colonic adenomatous polyps, and the control group comprised 360 patients without colonic adenomatous polyps on colonoscopy. Results: The risk of gastric IM was 1.42-fold higher in the study group (p<0.05). The risk of IM in patients aged >= 50 years with colonic polyps was 3.35-fold higher than in those aged <50 years (p<0.05). The risk of Helicobacter pylori infection in the study group was 1.07-folder higher than that in the control group (p<0.05). H. pylori infection prevalence was higher only in patients with high-grade colonic polyp dysplasia (p<0.05). There were no statistically significant differences in the proportion of incomplete IM between the groups (p<0.05). Conclusion: This study observed increased rates of gastric IM with colonic polyps. An increased risk of gastric IM was associated with higher grades of polyp dysplasia.