Wos İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4807
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Item Effects of Combined Visible and Infrared Light Rhinophototherapy in Patients With Allergic Rhinitis(2023) Koycu, Alper; Bas, Ceren; Musabak, Ugur H.; Erbek, Selim Sermed; Koca, Huseyin Samet; Babakurban, Seda Turkoglu; Bahcecitapar, Melike; https://orcid.org/0000-0003-1290-3509; 36266929; AAF-3650-2021Background Intranasal phototherapy offers an alternative treatment method for patients with allergic rhinitis who cannot benefit from intranasal corticosteroids and oral antihistamines. Different wavelengths have been tried with promising results. Objective In this present study, we aimed to investigate the effects of visible light-infrared light phototherapy on clinical improvements together with its cytologic effects in patients with allergic rhinitis. Methods Patients with confirmed allergic rhinitis were given a 4-week course of intranasal phototherapy treatment. Weekly symptom questionnaires were applied to monitor clinical effects. Nasal lavage specimens were obtained before the start and at the completion of the 4-week therapy. Fluorescence-activated cell sorting analyses of CD16(+), CD24(+), and CD 45(+) cells were performed. Statistical analyses are performed of weekly changes in symptoms and cell counts. Results CD45(+)CD16(high)CD24(+) neutrophil count in nasal lavages decreased significantly whereas CD45(+)CD16(dim/-)CD24(+) eosinophil counts significantly increased and CD45(+) granulocyte counts remained unchanged. Symptom scores including nasal itching, nasal discharge, nasal obstruction, sneezing, eye itching, throat itching, and ear itching all statistically decreased compared to baseline at the end of 4 weeks. Conclusion Four-week course of intranasal phototherapy with visible and infrared light leads to clinical improvement in allergic rhinitis patients.Item Olfactory disorders in patients with mild to moderate COVID-19: spontaneous recovery in one-month follow up(2021) Inan, Serhat; Ozer, Fulya; Erbek, Selim Sermed; Caylakli, Fatma; Odemis, Ilker; Kursun, Ebru; 0000-0003-2638-0163; 0000-0001-5381-6861; 0000-0001-8821-4481; 0000-0002-7333-2896; AFK-3690-2022; AAJ-1407-2021; AAG-2486-2022; ABC-1809-2020; AAP-7195-2020Objective: In this study, we aimed to evaluate olfactory disorders (OD) and recovery processes in patients with coronavirus disease 2019 (COVID-19) infection at three time periods within one month from the time of diagnosis. Methods: A total of 96 patients with COVID-19 participated in the study. Self-reported changes in olfactory functions and their effects on quality of life (QoL) were evaluated using the National Health and Nutrition Examination Survey, the Questionnaire of Olfactory Disorders-Negative Statements (QOD-NS), and Sino-Nasal Outcome Test (SNOT)-22. At the time of diagnosis, the patients were divided into three groups: anosmia, hyposmia, and no OD (control) group. Subsequently, olfactory functions were retested at the time of the first negative polymerase chain reaction (PCR) control test and one month from the time of diagnosis. Results: During the COVID-19 infection, 68.7% of patients had OD; of these, 37% had anosmia, and 29% had hyposmia. Dysgeusia was found in 44.8% of the patients. OD was the primary symptom in 10.8% of the patients. The QoL scores of those with anosmia and hyposmia were significantly lower than those with no OD in all three surveys (P <.05). The QOD-NS scores of those with OD lasting more than 14 days were significantly lower in all three surveys (P <.05). Of the patients with OD, 4.34% had no spontaneous recovery at the end of the first month. Conclusion: Recovery of OD is faster in patients with hyposmia than in those with anosmia. Although COVID-19related permanent OD is not commonly observed, treatment of OD that lasts for more than 15 days would be beneficial to avoid permanent sequelae.Item The Effect of Postmenopausal Osteoporosis on Middle Ear Resonance Frequency(2021) Baytaroglu, Berk; Jafarov, Sabuhi; Erbek, Selim Sermed; 35177390BACKGROUND: The effect of postmenopausal osteoporosis on the middle ear mechano-acoustic system is unknown. The aim of this study is to investigate whether or not middle ear resonance frequency is affected in females with postmenopausal osteoporosis. METHODS: The study included postmenopausal women aged 45-60 years, separated into 2 groups as females with postmenopausal osteoporosis and healthy postmenopausal females (control group). A detailed anamnesis was taken from all subjects and then the ear, nose, and throat examinations were done followed by pure tone audiometry, tympanometry, and multifrequency tympanometry tests. The groups were compared in respect of pure tone average, bone conduction threshold, RF, static admittance, and tympanometric peak pressure values. RESULTS: The mean age of the patients was 59.2 +/- 4.53 years (range, 48-65 years) in the postmenopausal osteoporosis group and 57.11 +/- 4.27 years (range, 48-65 years) in the control group (P>.05). The mean resonance frequency values for the postmenopausal osteoporosis and control group were 954.41 +/- 127.47 and 935.29 +/- 126.39 Hz (P>.05). The mean static admittance values for the postmenopausal osteoporosis and control group were 0.82 +/- 0.33 and 0.85 +/- 0.3 mmho, and mean tympanometric peak pressure values were -7.35 +/- 18.52 and -6.94 +/- 19.52 daPa (P>.05 for both static admittance and tympanometric peak pressure). The mean pure tone averagevalues for the postmenopausal osteoporosis and control group were 20.96 +/- 6.82 and 15.60 +/- 7.81 dB, and mean bone conduction threshold values were 17.57 +/- 6.03 and 12.10 +/- 6.52 dB (P<.05 for both pure tone average and bone conduction threshold). CONCLUSIONS: The results showed that the middle ear resonance frequency values were not affected in postmenopausal osteoporosis patients, but there was seen to be greater sensorineural hearing loss in females with postmenopausal osteoporosis compared to healthy postmenopausal females.Item Fractalkine (CX3CL1) and its receptor (CX3CR1) in children with hypertrophic adenoid and chronic otitis media with effusion(2020) Inan, Serhat; Babakurban, Seda Turkoglu; Erbek, Selim Sermed; Terzi, Yunus Kasim; Sahin, Feride Iffet; 0000-0001-7308-9673; 0000-0001-5067-4044; 0000-0003-4825-3499; 0000-0001-5612-9696; 0000-0001-8821-4481; AAC-7232-2020; AAI-8856-2021; AAJ-1407-2021; B-7604-2019; B-4372-2018Background: Adenoid hypertrophy (AH) is one of the possible causes of chronic inflammation in the middle ear. It has been suggested that CX3CL1 and its specific receptor (CX3CR1) could be related with the pathogenesis of some inflammatory diseases. The aim of the present study was to evaluate the role of CX3CL1 and CX3CR1 in the pathogenesis of AH with chronic otitis media with effusion (COME) in children. Materials and methods: Adenoid tissue samples were obtained from 91 pediatric patients and divided into two groups: adenoidectomy only for AH (n: 47) and adenoidectomy in conjunction with ventilation tube insertion for AH + COME (n: 44). Expression levels of CX3CL1 and CX3CR1 genes were compared. Results: Expression levels of CX3CL1 and CX3CR1 in hypertrophic adenoid tissue were not significantly different between the AH + COME and All only groups. Although no significant difference was detected in the expression of CX3CL1 in the adenoid samples, the expression of CX3CR1 was higher in children older than 48 months. Conclusions: When allergy, atopy and chronic adenoiditis does not exist to obstructive adenoid hypertrophy, inflammatory fractalkine chemokine expression levels in adenoid tissue was not observed to be increased in children with COME.Item The differences in the expression of fractalkine and its receptor in conditions of tonsillar hypertrophy and chronic tonsillitis(2019) Hetemoglu, Elif Koclu; Babakurban, Seda Turkoglu; Terzi, Yunus Kasim; Sahin, Feride Iffet; Erbek, Selim Sermed; 0000-0001-5612-9696; 0000-0001-7308-9673; 30554983; B-4372-2018; AAC-7232-2020Objective: Fractalkine, member of chemokine family, is involved in many inflammatory processes in the human body. The aim of this study is to compare expression levels of fractalkine ligand and its receptor in chronic tonsillitis and hypertrophic tonsil samples. Methods: The study was conducted at Baskent University Departments of Otorhinolaryngology and Medical Genetics. It is designed as a prospective, non-randomized, controlled clinical study. Total 97 samples, obtained from adenotonsillectomy due to chronic tonsillitis or tonsillar hypertrophy, were participated in the study. Fractalkine and its receptor expression levels were determined and comparison was made between the tissue groups. c.839C > T (T280 M) polymorphism of fractalkine receptor was analyzed, then relationship between polymorphism and the expression level of fractalkine receptor was investigated. Results: Fractalkine receptor expression was significantly higher in the hypertrophic tonsil group than chronic tonsillitis group (p < 0.05). Conclusion: Fractalkine, member of chemokine family, and its receptor may play role in preventing chronic-recurrent tonsillitis. (C) 2019 Elsevier B.V. All rights reserved.Item How much are the incidental abnormalities on brain MRI clinically significant in otolaryngology practice?(2016) Koc, Ayca Ozbal; Ertugay, Cigdem Kalaycik; Cevik, Halime; Erbek, Selim SermedObjective: We aimed to investigate the frequency of incidental diagnosis of paranasal sinus and mastoid abnormalities on brain magnetic resonance imaging (MRI) and its correlation with symptoms of patients. Methods: We examined 100 patients who underwent brain MRI due to several different complaints other than sinusitis and mastoiditis. The patients who had any nasal or otologic pathology in otolaryngology examination were excluded from the study. Afterwards, a total of 65 patients were included into the study. The questionnaire consisted of otological symptoms and Sino-nasal Outcome Test (SNOT-20), Lund and Mackay scoring system for rhinosinusitis were filled by all patients immediately prior to imaging. The analysis of the MRI scan in terms of rhinosinusitis according to the Lund-Mackay radiological scoring and mastoiditis was performed by the same radiologist. Results: The mean age of 65 patients was 46.62 +/- 17.73 years. Eighteen (27.7%) of these were men and 47 (72.3%) were women. In 26 (40%) of 65 patients, MRI demonstrated mastoiditis. We could not find any statistically significant correlation between mastoiditis and upper respiratory tract infection (p=0.896). There was no statistically significant relationship between radiological scores and total sinus symptom scores (p=0.93). Additionally, we could not find any correlation between radiological scores and SNOT-20 (p=0.923). Conclusion: Our findings demonstrated that although some of these patients had various symptoms of sinus or mastoid diseases, these symptoms had no statistically significant correlation with the radiological diagnosis. In conclusion, radiologists should advise clinical correlation of their radiologic findings rather than reporting a clinical diagnosis such as sinusitis and mastoiditis.