Wos İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/11727/4807

Browse

Filters

2018 - 20193

Settings

Author: search.filters.author.Divrik, Rauf Tanersearch.filters.applied.f.language: search.filters.language.eng

Search Results

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    The prognostic value of routine second transurethral resection in patients with newly diagnosed stage pT1 non-muscle-invasive bladder cancer: results from randomized 10-year extension trial
    (2019) Eroglu, Askin; Ekin, Rahmi Gokhan; Koc, Gokhan; Divrik, Rauf Taner; 31760524
    Purpose To evaluate the impact of routine second TUR on the long-term outcome of patients with newly diagnosed stage pT1 non-muscle-invasive bladder cancer (NMIBC) Material and methods A total of 210 patients (mean age 62.1 years, 89.5% were males) with stage pT1 NMIBC who underwent first TUR were prospectively randomized into two groups including second TUR (n = 105) and no second TUR (n = 105) groups. Data on recurrence, disease progression, 7-year and 10-year recurrence-free survival (RFS), progression-free survival (PFS) and overall survival (OS) were recorded. Results The median follow-up time was 119 months (IQR 65-168). Per-protocol (PP) analysis revealed that compared to patients without second TUR, patients with second TUR had significantly higher 5-year, 7-year and 10-year rates for RFS (59.4%, 57.9% and 54.8% vs. 36.3%, 31.7% and 26.8%, respectively, p < 0.001) and PFS (93.3%, 91.9% and 90.4% vs. 74.0%, 71.4% and 68.5%, respectively, p < 0.001). According to PP and intention-to-treat (ITT) analyses, the 10-year OS rate was significantly higher in patients with second TUR (59.1 vs. 40.8%, p = 0.004). Multivariate analysis revealed that undergoing second TUR (OR 1.661, 95% CI 1.156-2.385, p = 0.006) was an independent determinant of prolonged OS. Conclusions In conclusion, these findings indicate the prognostic value of second TUR in stage pT1 NMIBC patients, not only for RFS and PFS advantages but also for the long-term OS advantage. Therefore, second TUR should be routinely performed in all stage pT1 NMIBC patients with life expectancy of at least 10 years, given the positive contribution to all oncological outcomes.
  • Thumbnail Image
    Item
    Prevalence of Anal Incontinence and Constipation in Female Patients with Urinary Incontinence
    (2018) Eroglu, Askin; Saracoglu, Musa; Divrik, Rauf Taner
    Objective: To investigate the prevalence of anal incontinence and constipation in patients with urinary incontinence. Materials and Methods: Adult female patients who presented with the complaint of urinary incontinence were evaluated with anal incontinence and constipation assessment survey prepared on the basis of "the International Consultation on Incontinence Questionnaire-Short Form", "the Overactive Bladder 8-Question Awareness Tool" and "the Rome 3" criteria. Results: Two hundred female patients with urinary incontinence were evaluated. The patients were in the age group of 18-88 with the average age of 55.24 +/- 16.86 standard deviation. Stress incontinence was present in 19.5%, urge incontinence in 36% and mixed incontinence in 44.5% of the subjects. Seventy-seven percent of patients presented with flatal incontinence, 7.5% with fecal incontinence and 52.5% presented with constipation. There was no difference between sub-groups created according to age groups and types of urinary incontinence in terms of frequency of gastrointestinal symptoms. The incidence of constipation was statistically significantly higher in patients presenting with findings of urinary incontinence for more than 1 year and in those with overactive bladder (p< 0.01 and p< 0.001, respectively). Conclusion: Flatal incontinence was found in 77%, fecal incontinence in 7.5% and constipation in 52.2% of female adult patients with urinary incontinence. The incidence of constipation was higher at the level of statistical significance in patients presenting with findings of urinary incontinence for more than 1 year and in those with overactive bladder.
  • Thumbnail Image
    Item
    Development of Antibiotic Resistance Against Ureaplasma urealyticum Strains Isolated from Urogenital Samples
    (2018) Eroglu, Askin; Saracoglu, Musa; Divrik, Rauf Taner
    Objective: To assess any change in the antibiotic sensitivity of Ureaplasma urealyticum strains isolated from urogenital samples in the course of time. Materials and Methods: Hospital records were retrospectively examined and cases with growth of U. urealyticum in urogenital samples in the years 2008 and 2013 were identified. Furthermore, the change in the course of time was examined by taking into consideration the cases we reported in 2001. Results: Higher rates of sensitivity against tetracycline and doxycycline were observed in 60 patients with isolated U. urealyticum. Higher rates of resistance against ofloxacin and ciprofloxacin were observed. A significant difference was found in resistance against antibiotics when the records of 2008 and 2013 were compared. A statistically significant increase was found in resistance against ofloxacin and ciprofloxacin when the records of 2001 were compared with the records of 2008 and 2013 (p< 0.0005). Conclusion: U. urealyticum strains demonstrated high levels of resistance to quinolones. Resistance development is increasing in the course of time. Sensitivity against tetracycline and doxycycline has continued at high rates. It would be beneficial to consider these results during empirical treatment to be applied in cases ineligible for culturing.