TR-Dizin İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4808
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Item The Relationship Between Vitamin B12 and Vitamin D Levels and Subjective Cognitive Complaints in Patients with First Episode Major Depressive Disorder(2021) Ulusoy, Selen Isik; Horasanli, Bahriye; Kulaksizoglu, Sevsen; 0000-0003-3142-1011Objective: Cognitive dysfunction is an important component of major depressive disorder (MDD). The aim of this study is to investigate the relationship between vitamin B12 and D and subjective cognitive complaints in patients with first-episode MDD. Method: In this cross-sectional study, patients (n=120) diagnosed with first-episode MDD filled out self-report questionnaires that evaluate subjective neurocognitive symptoms (Perceived Deficits Questionnaire-Depression [PDQ-D] and British Columbia Cognitive Complaints Inventory [BC-CCI]). Disease severity was evaluated using the Hamilton Depression Rating Scale (HDRS). Serum 25-OH vitamin D and vitamin B12 levels were measured using a chemiluminescence microparticle immunoassay technology. Results: The PDQ-D and BC-CCI scores were significantly higher in patients with combined vitamin B12 and D deficiency than patients with normal vitamin levels. We found a negative correlation between vitamin B12 level and HDRS, BC-CCI and PDQ-D scores. In addition, there was a positive correlation between HDRS scores and PDQ-D and BC-CCI scores. Linear regression analysis revealed that HDRS score and vitamin B12 level have influence on PDQ-D and BC-CCI scores. Conclusion: In this study, it was found that subjective cognitive impairment was significantly higher in MDD patients with both of vitamin B12 and vitamin D deficiency. Vitamin B12 levels were also associated with depressive symptom severity and subjective cognitive impairment. Depression severity and vitamin B12 level were found to be significant predictors of subjective cognitive impairment. Our findings highlight the importance of depression severity and vitamin B12 and D levels during routine clinical evaluation of MDD.Item Analysis of Quality of Life, Depression, and Sexual Function in Patients on the Liver Transplant List(2021) Fidan, Cihan; Akdur, Aydincan; Kirnap, Mahir; Selcuk, Haldun; Yildirim, Sedat; Moray, Gokhan; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0002-8726-3369; 34609310; AAJ-8097-2021; AAA-3068-2021Background: I he only treatment in patients developing liver failure is liver transplantation. According to the Ministry of Health, the number of patients waiting for a liver transplantation is 2141, the average waiting period for liver transplantation is approximately 5 years, and 15-18% of these patients lose their life while waiting for transplantation. In these patients, limitations in daily activities and depression-anxiety are commonly found. The aim of this study was to analyze life quality, depression symptoms, and existence of sexual functional disorders of patients waiting for liver transplantation. Methods: A total of 74 patients, who were registered in Baskent University Hospital between 2015 and 2018, were included into the study. Short Form-36, Beck Depression Inventory, and Arizona Sexual Experiences Scale were applied to 56 patients who approved study. Results: Most of the patients were male (64.3%), and the mean age was 46 (18-64). Short Form-36 scores were low in all patients. The mean Beck Depression Inventory score of patients was found as 18.4 +/- 11.3, and they were suffering from moderate depressive symptoms. According to Arizona Sexual Experiences Scale, total mean scores of males was found as 16.3 +/- 5.5, and for females, it was 19.5 +/- 5.3 with a statistically significant difference (P < .05). It was found that sexual dysfunction mostly had moderate to mild. Conclusion: Depression and sexual dysfunction are common in patients with chronic liver diseases, and their life qualities deteriorate significantly. It is anticipated that evaluation of these patients in terms of psychological issues and sexual dysfunction will increase their quality of life during the organ waiting period and affect their well-being post-transplant.Item Increased Levels of Anxiety, Depression, and Secondary Trauma in Radiation Oncologists during COVID-19 Pandemic: A Preliminary Report from Turkey(2021) Topkan, ErkanOBJECTIVE We surveyed the anxiety, depression, and secondary trauma levels of Turkish Radiation Oncologists related with COVID pandemics. METHODS An anonymous online questionnaire survey was created to evaluate levels of depression, anxiety, and secondary trauma among Turkish Radiation Oncologists. The survey included demographics and occupational status, Secondary Traumatic Stress Scale (STSSS), The Beck Depression Inventory (BDI), The Beck Anxiety Inventory (BAI), and State-Trait Anxiety Inventory (STAI). RESULTS Seventy-two respondents provided the power of about 91.4% for the significance level of 0.05. The variance homogeneity was checked by the Levene test, the effect of COVID-19 on psychology is higher in the group of >19 (9.02 +/- 0.820), as well as the effect of social isolation (8.02 +/- 1.622), the STSS scores (34.28 +/- 9.062), the STAIS scores (60.46 +/- 5.296), the STAIT scores (82.21 +/- 9.298), the BDI scores (22.68 +/- 2.788), and the BAI scores (21.04 +/- 9.321). The multiple regressions to estimate BDI revealed statistically significant effects in STAIS, BAI, and STAIT. There is a significant correlation between STSS, STAIS, STAIT, BDI, BAI, the effect of COVID-19 on psychology, and the effect of social isolation. CONCLUSION We have established one of the first studies demonstrating the effects of COVID-19 pandemic on depression, anxiety levels, and secondary trauma on a special physician population, the Radiation Oncologists, who specifically do not directly take part in COVID19 management.Item The Screening of Comorbid Depressive Disorders and Associated Risk Factors in Adult Patients with Type 2 Diabetes(2020) Demirci, Ibrahim; Haymana, Cem; Sonmez, Alper; Bolu, Abdullah; Kirnap, Nazli; Demir, Orhan; Meric, Coskun; Oysul, Guven; Aydogdu, Aydogan; Ersoz Gulcelik, Nese; Azal, OmerObjective: Elevated depressive symptoms and disorders affect one in five patients with diabetes. Current guidelines recommend screening depression in the diabetic population. Turkey has the highest (13.7%) prevalence of diabetes in Europe. However, there are limited data about the prevalence of depressive disorders among diabetic patients in Turkey. We aim to investigate the prevalence of a comorbid depressive disorder in Type 2 diabetic patients who were referred to the Endocrinology outpatient unit of a tertiary hospital. Material and Methods: All the Type 2 diabetic patients admitted to our endocrinology department were consecutively included in the study. Their sociodemographics, concomitant diseases and medications, macro and microvascular complications, lifestyle and personal habits, and treatment regimens were obtained by a specifically designed questionnaire. Laboratory data were obtained from the hospital records. The Patient Health Questionnaire-9 (PHQ-9), a depression screening tool, was used as a screening method for depression. Patients with a score of 10 or above determined high risk for depressive disorder according to PHQ-9. The scores were re-evaluated by a psychiatrist to minimize the false negative and positive results. Result: A total of 460 patients with Type 2 diabetic were enrolled in this crosssectional study. 18.9% (n=87) of the participants were found to have depressive disorders according to the psychiatric evaluation done after the PHQ-9 questionnaire. Patients with depressive disorders were predominantly female (69.0% vs. 55.5%; p=0.022), younger (57.2 +/- 10.5 vs. 60.0 +/- 9.5; p=0.014), had higher HbAlc (8.51 +/- 2.51 vs. 7.98 +/- 2.05; p=0.042), total cholesterol (205.6 +/- 44.2 vs. 194.2 +/- 46.0; p=0.045), LDL-cholesterol (123.1 +/- 37.8 vs. 113.1 +/- 35.4; p=0.026) and non-HDL-cholesterol (158.5 +/- 41.61 vs. 146.6 +/- 42.7; p=0.024). These patients had frequent neuropathy (37.3% vs. 19.0%, p=0.001), they were less likely to perform exerdse (31.8% vs. 53.1%; p<0.001) while smoke in excess (31.4% vs. 14.3%; p<0.001). The analysis showed that female gender (OR=4.4; 95% CI=1.6-12.8; p=0.005) and smoking (OR=7.6; 95% CI=2.8-20.5, p<0.001) are independent determinants of a depressive disorder. Conclusion: Approximately one-fifth of diabetic patients had a depressive disorder, and their metabolic parameters were worse than those without a depressive disorder. Therefore, to assess a diabetic patient from all aspects, screening for depressive disorder should be made an indispensable part of the evaluation process.Item Levels of depression, anxiety and quality-of-life of kidney and liver donors in a university hospital in Ankara(2019) Karagol, Arda; ABE-8882-2020Objective: The psychosocial assessments of live kidney and liver donor candidates constitutes an important issue whereas many studies has drawn attention to the donation's correlation with anxiety and depression as well as the unwanted psychosocial outcomes. There are studies that find psychiatric disorders that appear in the post-operative period after donation lower or higher compared to the normal population. Altruism is considered as a concept that ensures vital stress management and is defined as 'the degree of obligation felt in situations where you are supposed to help others'. It is believed that altruistic behavior is a mature defense mechanism, which prevents the development of psychiatric disorders such as anxiety disorder and depression and protects the individual against those psychiatric disorders. Methods: Our study included 51 participants who were donors of kidney and liver at Ankara Hospital of Baskent University between the years 2016 and 2017, and who accepted to participate in the study. The participants were given the Beck Depression Inventory, Beck Anxiety Inventory, SF-36 Quality-of-Life Scale and a Sociodemographic Questionnaire. Results: When the donors who participated in the study were compared with the Turkish society standards, the patient group was found to obtain significantly higher scores than the society average in the quality-of-life subscales 'physical function', 'difficulty in physical role', 'mental health' and 'pain', therefore, they were found to have a higher quality-of-life. Among the donors who participated in our study, the rate of those with moderate to severe depression was found to be 3.9% and of those with moderate to severe anxiety was found to be 'zero'. Discussion: Organ donation may be an altruistic behavior acting as a defensive mechanism that protects the individual against mental disorders such as depression and anxiety and increasing the quality-of-life.Item Intensive Care Psychological Assessment Tool (IPAT): Turkish validity and reliability study(2019) Duman, Berker; Kotan, Zeynep; Kotan, Vahap Ozan; Mutlu, Nevzat Mehmet; Doganay Erdogan, Beyza; Sayar Akaslan, Damla; Tatli, Safiye Zeynep; Kumbasar, Hakan; 31408296Background/aim: It is of crucial importantance to be able to detect acute psychological distress in patients. 'the Intensive Care Psychological Assessment Tool (IPAT) was developed for this purpose in intensive care units. This study aims to evaluate the validity and reliability of the Turkish version of IPAT. Materials and methods: In total, 98 patients were included. To assess concurrent validity, the Intensive Care Experiences Scale (ICES) and the Hospital Anxiety Depression Scale were performed. Cronbach's alpha coefficient was used to estimate internal consistency. Interitem and item-total score correlations were also performed. Sensitivity and specificity were derived for concurrent anxiety and depression. Results: The internal reliability was good. Cronbach's a = 0.85. Items were well-correlated, with an average interitem correlation of 0.38. The concurrent validity of IPAT was good. Correlation between IPAT scores, anxiety, depression, ICES, and the diagnosis of delirium were as follows, respectively: r = 0.61, P < 0.01, r 0.54, P < 0.01, r = -0.66, P < 0.01, r = 0.37, P < 0.01. With a cutoff score of > 6, IPAT showed 85% sensitivity and 61% specificity to detect concurrent anxiety, and 74% sensitivity and 82% specificity to detect concurrent depression [AUC = 0.77 (95% CI, 0.68-0.87) and 0.84 (95% CI, 0.76-0.92), respectively). Conclusion: The Turkish version of IPAT was found to be a valid and reliable tool to assess acute psychological distress among patients in intensive care units.Item Factors Associated with Depression in Obsessive-Compulsive Disorder: A Cross-Sectional Study(2015) Altintas, Ebru; Taskintuna, Nilgun; 28360738Introduction: Major depressive disorder (MDD) is the most frequent comorbid psychiatric condition associated with obsessive-compulsive disorder (OCD). This study aimed to evaluate the prevalence of current depression in OCD, differences in socio-demographic and clinical characteristics, and obsessive-compulsive symptoms between OCD patients with and without depression. Additionally, factors associated with comorbid depression were investigated in our study. Methods: In total, 140 OCD patients, of which 63 were OCD patients with MDD (OCD+MDD, n=63) and 77 were OCD patients without depression (OCD-MDD, n=77) were included in the study. All patients were diagnosed with OCD using the Structured Clinical Interview for DSM-IV. The Yale-Brown Obsessive-Compulsive Scale, Beck Anxiety Scale, and Beck Depression Scale were administered to all patients. After the socio-demographic and clinical variables and scales were accomplished, the OCD patients divided into two groups as OCD with or without depression and we compared their mean scores of the variables and scales. Univariate analyses were followed by logistic regression. Results: There were no significant differences in age, gender, marital status, period without treatment, profession, medical and family history, and social support between the two groups. Anxiety, depression, and obsession and compulsion scores were significantly higher in the OCD+MDD group. The avoidance, insight, instability, and retardation scores of the OCD+MDD group were also significantly higher than those of the OCD-MDD group. Conclusion: Our study suggests that many factors are strongly associated with depression in OCD. Positive correlations between poor insight, severity of obsession and compulsion, and stressful life events during the last six months increased the risk of depression in OCD. Our study suggests that high level of avoidance, instability and retardation, history of suicidal attempt, and delayed treatment are other notable factors associated with the development of depression in OCD.