TR-Dizin İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11727/4808
Browse
7 results
Search Results
Item Metaplastic Carcinoma of the Breast: Analysis of 38 Cases from a Single Institute(2020) Hasbay, Bermal; Aka Bolat, Filiz; Aytac, Huseyin Ozgur; Aslan, Hulya; Purbager, Aysin; 0000-0002-7138-246X; 0000-0002-3583-9282; 31769499; AAK-9104-2021; AAJ-7913-2021Objective: To evaluate the pathological and radiological features, hormone profiles, surgery and treatment methods of metaplastic breast carcinoma cases diagnosed at our center in the light of current literature. Material and Method: A total of 38 metaplastic breast cancer cases diagnosed between 2006-2018 at our center were included in the study. The patients were evaluated in terms of age, tumor size, localization, histological grade, hormone profiles (ER, PR, Her2-neu), American Joint Committee on Cancer (AJCC) Tumor, Lymph node status, Metastases (TNM) stage, progression, survival, radiological features, types of surgery and therapy modalities (chemotherapy and / or radiotherapy). Results: The age of the patients ranged between 32 and 95 years. Pathological evaluation of cases showed that 14 were pure epithelial (IC-NST + squamous cell carcinoma) and 24 were metaplastic carcinomas with mesenchymal differentiation. Ductal carcinoma in situ (DCIS) was accompanying an invasive component in twenty cases. Seventeen patients had lymph node metastasis. Twelve patients developed distant metastasis. Thirty patients were triple negative for hormone receptors. The mean follow-up period of the patients was 34 months. The estimated life expectancy was 116 months. All of the patients received chemotherapy and 28 patients received adjuvant radiotherapy. There was no correlation between tumor size and lymph node or distant metastasis in our series. Our findings are consistent with the literature. Conclusion: Metaplastic breast carcinoma is a rare entity among breast carcinomas. Metaplastic carcinomas of the breast draw attention with the differences in their clinical course and the radiological and pathological heterogeneity.Item A Comparison of The Effects of Lidocaine and Saline Injection on Pain, Disability, and Shear-Wave Elastography Findings in Patients with Myofascial Trigger Points(2019) Analan, Pinar Doruk; Aslan, Hulya; Umay, Sermin Tok; 0000-0002-7161-016X; AAW-6708-2020BACKGROUND/AIMS To compare the effects of lidocaine injection (LI) and saline injection (SI) on the myofascial trigger points (MTrPs) in the trapezius muscle on pain, disability, and shear-wave elastography (SWE) in patients with myofascial pain syndrome (MPS). The secondary aim was to evaluate the correlations between SWE and pain with disability scores. MATERIAL and METHODS This prospective study included 45 patients with MTrPs due to MPS. The patients were evaluated using the visual analog scale (VAS), Neck Disability Index (NDI), and SWE immediately before and 15 days after the injections. The patients were randomly assigned to an LI (n=20, 30 MTrPs) or an SI (n=25, 32 MTrPs) group. The LI group was treated with lidocaine, and the SI group was treated with SI. RESULTS Visual analog scale and NDI scores improved significantly in both groups after injection (p <= 0.05). In addition, 16 MTrPs in the LI group and 3 MTrPs in the SI group were completely resolved. Maximum shear-wave velocity (V(s)max) and mean shear-wave velocity significantly decreased in the SI group after injection (p=0.025). The size of MTrPs decreased in the LI group (p=0.02). Pre-injection V(s)max and resting VAS were weakly correlated (r=0.309). No significant correlation was found on other SWE measurements with VAS and NDI scores (r<0.3). CONCLUSION Lidocaine injection and SI effectively improved the disability and pain in patients with MPS. LI is more effective than SI in reducing the size of the trigger points and resolving MTrPs. SWE findings may not completely reflect the severity of pain and correlate with disability.Item Not Otherwise Specified-Type Sarcoma of Breast with CD10 Expression: Case Report(2019) Hasbay, Bermal; Bolat, Filiz Aka; Aslan, Hulya; Aytac, Huseyin Ozgur; 31620687Primary breast sarcomas are very rare and account less than 1% of invasive breast carcinomas. Primary sarcomas of breast are leiomyosarcoma, angiosarcoma, liposarcoma, fibrosarcoma, rhabdomyosarcoma, malignant peripheral nerve sheath tumor and pleomorphic sarcoma. Recently, a new CD10 positive group of sarcoma was identified. These tumors cannot be classified as a soft tissue sarcoma and show diffuse strong positive staining pattern with CD10 (NSCD10). Herein we report clinical and morphological characteristics of two cases diagnosed with not otherwise specified-type sarcoma with CD10 expression by histologically and immunohistochemical findings with the literature. NSCD10 shows similarity with leiomyosarcoma and sarcomatoid-type metaplastic carcinoma histomorphologically among specific sarcomas of breast. CD10 expression should be taken into consideration in the presence of not diagnosed and not specified tumors and CD10 should be added to the immunohistochemical panel.Item Postoperative Spondylodiscitis and Epidural Abscess Becoming Visible on Magnetic Resonance Imaging before Positive Laboratory Tests(2015) Pourbagher, Aysin; Tok, Sermin; Aslan, HulyaPost operative disc space infection is relatively uncommon. The incidence of postoperative disc space infection is 0.21 %-3.6 % in association with all vertebral surgical procedures. Surgery causes a variety of neuroendocrine and metabolic responses which generally results in immunosupression. Clinical results of immunosupression include delayed wound healing and septic complications. In this article, we report magnetic resonance imaging findings of a case with spondylodiscitis and spinal epidural abscess in which the imaging findings were apparent before the infection and inflammation related laboratory findings laboratory findings become positive. She has a history of surgery due to lumbar herniated disc a month. She was complaining of back and left leg pain. We performed contrast-enhanced MR imaging. MR imaging showed post operative changes at level L5 and S1. There was contrast enhancement at the level of the surgical gap in the posterior paravertebral muscles. MR imaging may help to differentiate postoperative spondylodiscitis and epidural abscess from early postoperative changes even before the laboratory tests appearing positive. In our case, surgery induced immunosupression may cause the infection and inflammation related laboratory findings being within normal limits at the beginning.Item Granulocytic sarcoma of finger: a case report(2016) Purbager, Aysin; Ozen, Merve; Aslan, Hulya; Tok, Sermin; Kocer, EmrahGranulocytic sarcoma is an extramedullary tumor of immature myeloid cells. Such tumors may be located in any part of the body. We report a case of isolated granulocytic sarcoma of finger; which, to our knowledge, is the first report of that localization. A thirty-year-old woman with acute myeloid leukemia (AML) presented with progressive swelling and onychoptosis at her right fourth finger. The distal phalanx was excised and the tumor turned out to consisted of atypical myeloid cells, infiltrating bone trabeculae. Despite its rarity, considering myeloid sarcoma of the finger as a possible diagnosis may prevent inappropriate treatment in leukemia patients.Item Magnetic resonance imaging findings of extraskeletal mesenchymal chondrosarcoma of wrist: a case report(2016) Pourbagher, Aysin; Aslan, Hulya; Bal, NebilExtraskeletal mesenchymal chondrosarcomas (EMC) are high grade malignant tumors that rarely involves wrist. Published reports about them are mostly based on conventional radiography, tomography and conventional magnetic resonance imaging (MRI) findings. We did not recognize any report of dynamic-contrast enhanced MRI so far. Herein, we present dynamic contrast enhanced and Diffusion Weighted MRI findings of a case with extraskeletal mesenchymal chondrosarcoma of the wrist. In conclusion, EMC might show peripheral enhancement at early arterial phase and restricted diffusion on MRI. The knowledge of the imaging spectrum of the EMC might help us suggesting the diagnosis.Item Quantitative elastography in differentiating benign and malignant breast lesions(2016) Purbager, Aysin; Pekoz, Burcak Cakir; Aslan, Hulya; Agildere, Ahmet Muhtesem; 0000-0003-4223-7017; 0000-0002-7138-246X; AAB-5802-2020; AAK-9104-2021Purpose: The purpose of this study was to evaluate the effectiveness of quantitative elastography in differentiating benign and malignant breast lesions that were detected by B-mode ultrasonography, to compare shear wave velocities of benign and malignant lesions, and to determine cut-off values differentiating malignant lesions from benign ones Material and Methods: In this prospective study we enrolled 254 breast lesions of 240 patients detected by B-mode ultrasonography, and underwent biopsy in our department. Shear wave elastography was performed to all lesions before biopsies. The patients who had radiotherapy or chemotherapy previously were not included. Elastography examinations were performed by one of the two radiologists specialising in breast radiology. The mean and median shear wave velocities, and standard deviation values were measured in meters/second. Both mean and median shear wave velocities were compared with histopathology results. Sensitivity, specificity, and the area under the curve were obtained by using a receiver operating characteristic curve analysis Results: The mean age of the patients, lesion size, mean and median shear wave velocities were significantly different between benign and malignant groups. The mean shear wave velocity of benign and malignant lesions were 3.59 +/- 1.2m/s and 5.59 +/- 1.9m/s, respectively. The cut-off value for the mean shear wave velocity was 4.08 m/s (71.6% sensitivity and 69.6% specificity) to differentiate malignant lesions from benign ones Conclusion: Quantitative elastography is an effective and complementary method making a significant contribution in differentiating benign and malignant lesions. In this respect, we believe that clinical usage of shear wave elastography should be generalized