Browsing by Author "de Ridder, M."

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    The Feasibility of Prostate-Specific Membrane Antigen Positron Emission Tomography(PSMA PET/CT)-Guided Radiotherapy in Oligometastatic Prostate Cancer Patients
    (2018) Guler, O. C.; Engels, B.; Onal, C.; Everaert, H.; Van den Begin, R.; Gevaert, T.; de Ridder, M.; https://orcid.org/0000-0001-6908-3412; https://orcid.org/0000-0001-9108-610X; https://orcid.org/0000-0002-2742-9021; https://orcid.org/0000-0003-3633-6203; https://orcid.org/0000-0003-4556-5681; https://orcid.org/0000-0003-4433-8807; 28795303; AAC-5654-2020; HOC-5611-2023; B-1285-2018; F-3248-2016; F-4794-2013
    To investigate the efficacy and toxicity of 68Ga-PSMA-HBED-CC (Ga-68-PSMA) PET-CT-guided RT in the treatment of oligometastatic prostate cancer retrospectively. A total of 23 prostate cancer patients with biochemical relapse, of which 13 were castration sensitive (CS) and 10 castration resistant (CR), were treated with intensity-modulated and image-guided RT (IMRT-IGRT) on 3 metastases detected by Ga-68 PSMA PET-CT. Androgen deprivation therapy was continued in CR patients. A total of 38 metastases were treated. The involved sites were pelvic bone (n = 16), pelvic lymph nodes (n = 11), paraaortic lymph nodes (n = 6), ribs (n = 3) and vertebral body (n = 2). The median PSA prior to RT was 1.1 ng/mL (range 0.1-29.0 ng/mL). A median dose of 43.5 Gy (range 30-64 Gy) was delivered by IMRT-IGRT in 12-27 fractions. At a median follow-up of 7 months (range 2-17 months), 19 patients (83%) were in remission. Four patients (17%) developed distant recurrences. The actuarial 1-year LC, PFS and OS rates were 100, 51 (95% CI 8-83%) and 100%. Univariate analysis demonstrated a statistically significantly better PFS in CS patients as compared to CR patients (1-year PFS 67 vs. 0%, p < 0.01). One patient experienced grade 2 acute gastrointestinal toxicity. Grade 3 or more toxicity events were not observed. By providing optimal LC, low toxicity and a promising PFS in CS patients, the current retrospective study illustrated that Ga-68 PSMA PET-CT-guided RT may be an attractive treatment strategy in patients with oligometastatic prostate cancer. Validation by randomized trials is eagerly awaited.