Browsing by Author "Zengin, Hatice Yagmur"

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Assessment of Mucosa-Associated Epithelial Chemokine, Thymus-Expressed Chemokine, Periostin and Zonulin Levels in Infants With Atopic Dermatitis
(2022) Koksal, Burcu Tahire; Zengin, Hatice Yagmur; Ozbek, Ozlem Yilmaz; 36386107
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. Skin and gut are the organs that first encounter antigens and environmental triggers. The mechanisms behind the relation between skin and gut immune responses in AD have not been identified yet. Aims and Objectives: To investigate mucosa-associated epithelial chemokine (MEC/CCL28), thymus-expressed chemokine (TECK/CCL25), periostin and zonulin levels in infants with AD. Materials and Methods: Children under one year old participated in the study. We used a propensity matching score. We included 39 infants who had active AD lesions at the time of evaluation. Serum MEC/CCL28, TECK/CCL25, periostin and zonulin levels were measured. Results: We examined age and sex matched 39 infants with AD and 39 healthy infants. Median value of zonulin was lower in infants with AD [49.2 (27.1-71.8) ng/mL] compared to healthy controls [58.5 (27.3-80.8) ng/mL] (P < 0.001). Infants with zonulin levels & LE;55.15 ng/mL had 11.64 times more risk of developing AD than the infants with zonulin levels > 55.15 ng/mL. Infants whose MEC/CCL28 levels were & GE;8.3 ng/mL had 5.83 times more risk of developing AD than the infants with MEC levels < 8.3 ng/mL. Duration of AD and SCORAD index score did not show correlation with MEC/CCL28, TECK/CCL25, periostin and zonulin levels. Conclusion: Low zonulin levels and high MEC/CCL28 levels in infants may show an increased association with AD.
Cephalometric Mandibular Dimensions in Growing Turkish Children: Trends of Change, Sex-Specific Differences, and Comparisons with Published Norms
(2022) Pamukcu, Hande; Tuncer, Nilufer Irem; Pelin, Ismail Can; Zengin, Hatice Yagmur; 36155404
Objective: The aims of this study were to investigate cephalometric mandibular dimensions in growing Anatolian Turkish children and to identify the periods of rapid growth for boys and girls. Furthermore, the secondary aim was to compare obtained values with published standards in the literature. Methods: A total of 528 pretreatment lateral cephalometric radiographs, grouped according to age and sex, were analyzed. Effective mandibular length, ramus height, and corpus lengths were comparatively evaluated within age groups for boys and girls and between sexes for the same age group. Data acquired from this study were compared with American, Canadian, Chinese, and European norms. Growth curves for mandible were constructed for each sex group. Results: Effective mandibular length was almost always significantly longer in boys, except for 9- and 12-year-age groups. Effective mandibular length in girls increased significantly between ages 8 and 10, 10 and 12, and 11 and 13 years, while in boys between ages 8 and 10, 9 and 11, and 13 and 15 years. Turkish girls had significantly shorter effective mandibular lengths than American girls at age 14. No significant difference was found between Turkish and Chinese girls and boys. Turkish girls and boys had significantly shorter corpus lengths from their Norwegian counterparts at age 12. Conclusion: Except for 9- and 12-year-age groups, effective mandibular length was almost always significantly longer in boys compared to the girls. It is suggested to use norm values from more recently conducted studies and which are representative of the studied population. Growth curves can be used to predict the approximate mandibular dimensions at a particular age.
A METHOD SUGGESTION TO MEASURE THE EFFECTIVENESS OF INFORMED CONSENT DURING TREATMENT PROCESS A Study on University Students
(2019) Buken, Erhan; Yasar, Zehtiye Fusun; Zengin, Hatice Yagmur; Buken, Bora; 0000-0002-4779-0623; 0000-0002-9855-2449; AAL-6847-2021; ABA-3224-2021
It is difficult and subjective to evaluate how much of the treatment information given has been understood by the patient during the informing process. Various court decisions show that courts expect a hundred percent success in the informing process. This research was conducted to observe the effectiveness of written and verbal information given under ideal conditions. A coronary angiography consent form was standardized to measure readability and understandability. Two different labyrinth tests were performed from the text. Tests were performed on the Baskent University students in Turkey. The labyrinth test's subjects responded to the test after verbal information, had an absolute rate of 32.5% while the labyrinth test's subjects, responded to prior verbal information had an absolute success rate of 15%. 87.7% of those who achieved absolute success, in the second labyrinth test, also received verbal information. In the verbally informed group, those who achieved absolute success in the first test were 8.5%, while this rate increased to 28.5% after verbal information. There was no difference between the groups, in terms of the number of correct answers and response time, in the first test. Significant differences between the groups' tests arose in the test administered after being informed. This paper argues that the difference of total correct answers between the groups, in the post-test, stems from the effects of verbal informing. This study observed that verbally informing is more effective than written informing. It concludes that the success of the informing process can be measured by developing standardized methods, though it is unlikely to achieve 100% success.
A Novel Technique for Prediction of Preterm Birth: Fetal Nasal Flow Doppler
(2021) Esin, Sertac; Okuyan, Erhan; Gunakan, Emre; Zengin, Hatice Yagmur; Hayran, Mutlu; Tohma, Yusuf Aytac; 0000-0001-8854-8190; 0000-0002-9855-2449; 0000-0001-9418-4733; 33180051; ABI-1707-2020; ABA-3224-2021; AAE-6482-2021
Objectives: Absence of fetal breathing movements (FBM) has been found to be a good predictor of preterm delivery in symptomatic patients. However, analysis of FBM patterns and Doppler measurement of them for preterm birth prediction have not been performed before. In this study, we aimed to investigate and analyze FBM patterns in symptomatic preterm labor patients by fetal ultrasonography and nasal Doppler. Methods: This was a multicenter, prospective cohort study. Singleton pregnant patients between 24 and 37 gestational weeks diagnosed with preterm labor were included in the study. Patients were evaluated in three groups: no FBM (Group 1), regular FBM (Group 2), irregular FBM (Group3). Results: Seventy-three patients were available for the final analysis after exclusion. Preterm delivery rate in 24 h in groups were 91.7, 32.7 and 100%, respectively. The absence of FBM (Group 1) was statistically significant for preterm delivery in for both 24 (91.7 vs. 42.6%, p=0.002) and 48 h (91.7 vs. 49.2%, p=0.006) when compared with fetal breathing positive Group 2 and 3. In fetal nasal Doppler analyses in Group 2, the inspiration/expiration number rate was significantly lower in the patients who delivered in 24 h (0 .98 +/- 0.2 vs. 1.25 +/- 0.57, p=0.015). By using fetal nasal Doppler, combination of absence of FBM or irregular FBM or regular FBM with inspiration number/expiration number (I/E) <1.25 detects 94.6% of patients who will eventually deliver in the first 24 h after admission. Conclusions: Examining FBM patterns and using nasal Doppler may help the clinician to differentiate those who will deliver preterm and may be an invaluable tool for managing preterm labor patients.
Possible Impact of Immunosuppressive Therapy Regimens on Histopathologic Outcomes of Abnormal Uterine Bleeding in Solid-Organ Transplant Recipients
(2018) Tohma, Yusuf Aytac; Akilli, Huseyin; Kirnap, Mahir; Haberal, Asuman Nihan; Akyel, Dilan; Zengin, Hatice Yagmur; Zeyneloglu, Hulusi Bulent; Kuscu, Esra; Ayhan, Ali; Haberal, Mehmet; https://orcid.org/0000-0001-9418-4733; https://orcid.org/0000-0002-5240-8441; https://orcid.org/0000-0001-9852-9911; https://orcid.org/0000-0002-9855-2449; https://orcid.org/0000-0002-0289-2642; https://orcid.org/0000-0002-3462-7632; 29851156; AAE-6482-2021; AAX-3230-2020; AAH-9198-2019; AAK-4587-2021; ABA-3224-2021; B-6487-2009; AAJ-8097-2021
Background: In this study, we aimed to determine the frequency of histopathologic outcomes of solid-organ transplantation in women with abnormal uterine bleeding (AUB) receiving immunosuppressive therapies. Methods: This is a retrospective study including a single-center experience. Data were extracted from hospital records, and solid-organ transplant recipients who were diagnosed with AUB were included. Results: Fifty-five of these patients were renal transplant recipients (79.7%), and 14 were liver transplant recipients (20.3%). Histopathologic examination showed various histopathologic patterns of endometrium in patients with AUB consisting of normal histopathologic findings of endometrium in 31 patients (48.4%); 29 hormonal imbalance during proliferative and secretory phases of menstrual cycle and two atrophic endometrium. Endometrial hyperplasia without atypia was observed in 11 patients (17.2%). Polyp was seen in 22 patients (34.4%); 21 endometrial polyp and one endocervical polyp. There were significant differences in terms of histopathologic findings among the three groups of patients according to different immunosuppressive regimens (P = .029). There was no endometrial hyperplasia in women receiving sirolimus-based immunosuppressive regimens. Moreover, there was no endometrial hyperplasia in the liver transplant recipient group. Conclusions: Sirolimus-based immunosuppressive regimens may be administered to patients who have risk factors for endometrial precancerous lesions, such as endometrial hyperplasia. However, additional well-designed, large-scale studies are warranted to confirm our findings.