Browsing by Author "Yuksel, S."

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    The Effect of Exercises on Serum Bmp-6 Levels of Knee Osteoarthritis
    (2016) Muratoglu, S.; Dincel, A. Sepici; Oksuz, N.; Yuksel, S.; Gunendi, Z.; Meray, J.; Bilgihan, A.
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    Efficacy of Adjuvant 9-Weeks Trastuzumab in Node-Negative T1A/B Her2-Positive Breast Cancer
    (2014) Sendur, M. A.; Aksoy, S.; Uncu, D.; Demir, H.; Yuksel, S.; Ekinci, A. S.; Kaplan, A.; Ustaalioglu, B. B.; Tufan, G.; Inanc, M.; Ozdemir, N.; Artac, M.; Tastekin, D.; Kacan, T.; Oguz, A.; Arpaci, E.; Yazilitas, D.; Gumus, M.; Zengin, N.; Altundag, M. K.; https://orcid.org/0000-0001-6512-6534; W-8004-2019
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    Evaluation of vascular endothelial growth factor-A and Endostatin levels in induced sputum and relationship to bronchial hyperreactivity in patients with persistent allergic rhinitis monosensitized to house dust
    (2015) Yilmaz, I.; Bayraktar, N.; Ceyhan, K.; Secil, D.; Yuksel, S.; Misirligil, Z.; Bavbek, S.; 26051834
    Background: Studies about the pathogenesis of bronchial hyperreactivity (BHR) in patients with persistent allergic rhinitis (PAR) and its relationship with lower airway remodeling are extremely limited. Objective: This study evaluated bronchial vascular remodeling via the measurement of angiogenic factor, vascular endothelial growth factor-A (VEGF-A), and anti-angiogenic factor, Endostatin, and evaluated their relationship with BHR in patients with PAR. Methods: The study group consisted of 30 patients with PAR monosensitized to house dust mites and 14 non-allergic healthy controls. All subjects underwent induced sputum and methacholine (M) bronchial provocation tests. VEGF-A and Endostatin levels were measured by ELISA in induced sputum supernatants. Results: The percentages of eosinophils in induced sputum were significantly increased in patients with PAR compared with healthy controls. There were no significant differences between patients with PAR and healthy controls in terms of levels of VEGF (37.9 pg/ml, min-max: 5-373 pg/ml vs. 24.9, min-max: 8-67 pg/ml, p = 0.8 respectively), Endostatin (532.5 pg/ml, min-max: 150-2125 pg/ml vs. 644, min-max: 223-1123 pg/ml, p = 0.2 respectively) and VEGF/Endostatin ratio (0.057 vs. 0.045, p = 0.8 respectively). In addition, there were no significant differences between patients who are BHR positive (n = 8), or negative to M (n = 22) in terms of levels of VEGF, Endostatin and VEGF/Endostatin ratio and no correlations among value of PD20 to M and levels of VEGF, Endostatin and VEGF/Endostatin ratio. Conclusion: We conclude that VEGF-A and Endostatin did not differ between patients with PAR and healthy controls regardless of BHR to M. (C) 2014 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L.U. All rights reserved.
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    Tunnel Widening After Single- Versus Double-Bundle Anterior Cruciate Ligament Reconstruction: A Randomized 8-Year Follow-Up Study
    (2017) Beyaz, S.; Guler, U. O.; Demir, S.; Yuksel, S.; Cinar, B. M.; Ozkac, G.; Akpinar, S.; https://orcid.org/0000-0002-5788-5116; https://orcid.org/0000-0002-5375-635X; https://orcid.org/0000-0002-7906-5039; 28840325; K-8820-2019; AAJ-4844-2021; AAL-4474-2021
    The purpose of this study was to compare the single-bundle (SB) and double-bundle (DB) surgical techniques for anterior cruciate ligament (ACL) reconstruction with regard to tunnel widening, isokinetic muscle strength, and clinical outcomes over an 8-year follow-up period. This study included 31 patients with ACL injury who underwent ACL reconstruction via the SB (n = 16) or the DB (n = 15) technique. Isokinetic and concentric strength measurements of the quadriceps and hamstring muscles were conducted at postoperative 6 months and postoperative 8 years, and 3D-CT scans of the knee joints were performed on the 2nd, 3rd and 6th month, and the 8th year postoperatively. Clinical evaluations were performed at 8 years postoperatively with the International Knee Documentation Committee (IKDC), Tegner, and Lysholm knee scoring systems. There was marked widening of the parts of the femoral tunnel close to the knee joint in both the SD and the DB groups. There was no difference between the two groups in terms of clinical results and isometric muscle strength at postoperative 8 years; however, there was a significant difference between the preoperative and 6 months postoperative clinical and strength results in both group (P < 0.05). There was no difference between the groups in IKDC score, Lysholm score, Tegner activity scale, and anterior drawer test at postoperative 8 years. On evaluation of the anteromedial bundles alone, the DB group had greater widening than the SB group. In this study, we have found that the tunnels continue to enlarge after 6 months. However, that has no impact in patients comfort and that did not made any change in our daily routine. On the other hand, we found that the reconstruction of the double-band ligament technique is useless for non-professional athletes.
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    Turkish Atypical Hemolytic Uremic Syndrome Registry: Patients Treated with Eculizumab
    (2016) Baskin, E.; Canpolat, N.; Yilmaz, A.; Yuksel, S.; Kalyoncu, M.; Melek, E.; Gonul, P.; Soylemezoglu, O.; 0000-0003-4361-8508; B-5785-2018