Browsing by Author "Yucel, A. E."
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Item Cyclophosphamide Therapy During the Covid19 Pandemic(2023) Bitik, B.; Oygur, C. S.; Kanbur, A. Yalcintas; Yucel, A. E.Item The Effect of Infliximab on Depressive Symptoms in Patients with Ankylosing Spondylitis(2015) Ersozlu Bozkirli, E. D.; Keskek, S. O.; Bozkirli, E.; Yucel, A. E.; 0000-0002-1644-6790; 25702318; I-6542-2012; E-9887-2014; 0000-0002-4860-9072Objectives: Ankylosing spondylitis is a chronic inflammatory disease which physically, psychologically, and socially affects the patient's life. Previous studies have reported a correlation between ankylosing spondylitis and depression. In this study we investigated the effect of infliximab on depression in ankylosing spondylitis patients. Methods: A total of 29 patients with ankylosing spondylitis were enrolled in this prospective study Infliximab was administered intravenously at a dose of 5 mg//kg at baseline, weeks 2 and 6. The measurements of morning stiffness, modified Schober's test, chest expansion, erythrocyte sedimentation rate, C-reactive protein, Bath ankylosing spondylitis disease activity index, Bath ankylosing spondylitis functional index and Beck depression inventory scores were compared between baseline and 12th week. Results: The modified Schobers' quotes test and chest expansion increased, the morning stiffness duration, erythrocyte sedimentation rate and C-reactive protein levels decreased after infliximab treatment (p<0.001, respectively). There was statistically significant decrease in Bath ankylosing spondylitis disease activity index, Bath ankylosing spondylitis functional index and Beck depression invantory scores of patients after 12 weeks (p<0.001, respectively). Conclusion: Infliximab can improve depression and its symptoms in patients with ankylosing spondylitis.Item The Effects of Infliximab Treatment on Depression, Anxiety And Sleep Disorders in Patients With Ankylosing Spondylitis(2014) Bozkirli, E. D. Ersozlu; Keskek, S. O.; Bozkirli, E.; Yucel, A. E.; https://orcid.org/0000-0002-1644-6790; https://orcid.org/0000-0002-1644-6790; E-9887-2014; E-9887-2014; I-6542-2012Item Endothelial Progenitor Cells in Takayasu's Arteritis(2014) Bozkirli, E. D. Ersozlu; Keskek, S. O.; Kozanoglu, I.; Yucel, A. E.; https://orcid.org/0000-0002-5268-1210; AAE-1241-2021; I-6542-2012Item High Levels of Endothelial Progenitor Cells Can Be Associated with Thrombosis in Patients with Behcet's Disease(2014) Bozkirli, E. D. E.; Keskek, S. O.; Kozanoglu, I.; Yucel, A. E.; https://orcid.org/0000-0002-5268-1210; https://orcid.org/0000-0002-4860-9072; 24774036; AAE-1241-2021Objective. Behcet's disease (BD) is a systemic disorder characterised by vasculitis. Endothelial progenitor cells are derived front the bone marrow and contribute to new vessel formation. The aim of this study was to investigate the level of endothelial progenitor cells in BD and BD-associated conditions. Methods. A total of 74 subjects were included in this study, of whom 44 and 30 subjects were patients with BD or healthy subjects, respectively. Endothelial progenitor cells were defined and measured by flow cytometry according to the expression of CD146, CD31 and CD34. We separated BD patients according to the active disease, pathergy test results, thrombosis and gender. MedCalc 12.5 software programme was used for statistical analyses. Results. The level of endothelial progenitor cells was comparable in patients with BD and healthy subjects (p=0.849). It was also comparable in patients with active or inactive BD (p=0.320). The level of endothelial progenitor cells was higher in patients with thrombosis (p=0.04). There was no statistical significant difference between pathergy positive and negative patients (p-=0.969). The level of endothelial progenitor cells was not correlated with age, C-reactive protein, erythrocyte sedimentation rate, white blood cells and disease duration (p>0.05). Conclusion. The level of endothelial progenitor cells was significantly higher in BD patients with thrombosis. On the other hand, they were not associated with disease activity, pathergy test and other conditions. EPCs may be a useful marker for thrombosis in patients with BD. In our opinion, this is the most expected result in this study.Item A Research Evaluating The Effectiveness and The Side Effects of High Dose Methotrexate Use in Combined Therapy of Rheumatoid Arthritis(2014) Tufan, M. Aydin; Bozkirli, E. D. Ersozlu; Koseoglu, H. Kart; Yucel, A. E.; https://orcid.org/0000-0002-2686-9762; AAJ-9057-2021; I-6542-2012Item THE ROLE OF CYCLOPHOSPHAMIDE CHEMOTHERAPY IN THE TREATMENT OF EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS(2020) Bitik, B.; Aydin, M.; Dalgic, G. Sahin; Kaskari, D.; Yucel, A. E.; 0000-0001-5803-915X; 0000-0002-0125-8746; AAI-9195-2021; H-7637-2016Item Sympathetic Skin Response For Autonomic Screening in Primary Sjogren's Syndrome(2014) Karaca, S.; Bozkirli, D. E. Ersozlu; Yerdelen, V. D.; Yucel, A. E.; I-6542-2012Item A Systematic Review Of Current Rheumatology Guidelines For Geriatric Perspectives(2022) Bitik, B.; Tezcan, M. E.; Yucel, A. E.