Browsing by Author "Yilmaz, Ozlem"

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    Comparison of practical application steps of the previously used adrenaline auto injector in Turkey (EpiPen) and the currently available adrenaline auto injector (Penepin): a multi-center study
    (2018) Yilmaz, Ozlem Ozbek; Topal, Erdem; Karagol, Hacer Ilbilge Ertoy; Yilmaz, Ozlem; Arga, Mustafa; Koksal, Burcu; Anil, Hulya; Harmanci, Koray; kutlug, Seyhan; Ozturk, Fadil; Razi, Hasan Cem; Turktas, Ipek; Demirsoy, Mehmet Sadik; Bekirtas, Arzu; 30459513
    Aim: It has been shown by a great number of studies that the correct use of adrenaline auto injectors prescribed to patients with anaphylaxis is associated with the design of the auto injector, in addition to training. The aim of this study was to compare the skills of adults in using two different auto injectors prescribed to patients with anaphylaxis. Material and Methods: Parents of patients aged between 1 and 18 years who referred to allergy outpatients were included in the study. Results: A total of 630 volunteers from nine centers were included in the study. Four hundred fifty-seven (72.5%) of the participants were females and 235 (37.3%) were undergraduates. The rate of showing all the steps of auto injector trainers correctly e by the participants was found as (60.2%) (n=379) for EpiPen and 42.9% (n=270) for Penepin (p<0.001). The most frequent mistake with both auto injector trainers was the step of "place appropriate injection tip into outer thigh/press the trigger so it clicks." When the preferences of the volunteers were asked after training and application, 527 (83.7%) chose EpiPen, stating that it was easier and simpler to use. Conclusions: Our study showed that the correct usage rates of both adrenaline auto injectors were much lower than expected and there could be mistakes in the application of both. It could be appropriate to make improvements in the design of Penepin, which is still the only available adrenaline auto injector in Turkey, such that its application steps will be simpler and quicker.
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    Oxygen Saturation/Minute Heart Rate Index: Simple Lung Function Test for Children
    (2017) Ozdemir, Ali; Dogruel, Dilek; Yilmaz, Ozlem; 27377817
    BackgroundThe severity of airway obstruction can be accurately determined on spirometry in children with asthma. Other assessments may include peak expiratory flow and pulse oximetry. In the present study, we evaluated the validity and reliability of oxygen saturation/minute heart rate (SpO(2)/MHR) index in the prediction of degree of severe airway obstruction in children with asthma. MethodsThis was a retrospective study of children aged 7-17 followed for asthma at Mersin Women and Children's Hospital. The study compared SpO(2)/MHR ratio with forced expiratory volume in 1 s (FEV1) measured on spirometry, an important indicator of small airway obstruction. A total of 296 patients were included in the study, and classified either as having normal FEV1 (FEV1 > 80% of predicted, n = 178) or severely reduced FEV1 (FEV1 < 60% of predicted, n = 118). Positive and negative predictive values (PPV and NPV), sensitivity and specificity of SpO(2)/MHR index in predicting low FEV1 were calculated on receiver operating characteristics analysis. ResultsAn SpO(2)/MHR ratio cut-off <0.90 was associated with a PPV of 83.14%, NPV of 71.77%, sensitivity of 80.34% and specificity of 75.42% in predicting low FEV1. ConclusionsSpO(2)/MHR ratio appears to be a highly useful index to assess airway obstruction in older children with asthma. Thus, it can be used as a marker of airway obstruction severity when spirometry is not available.
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    Vitamin D Status in Infants with Two Different Wheezing Phenotypes
    (2016) Ozdemir, Ali; Dogruel, Dilek; Yilmaz, Ozlem; 0000-0003-2971-283X; 27345567; AAG-5976-2019; F-6136-2016
    Objective To investigate vitamin D levels in patients with recurrent wheeze at early ages of childhood. Methods In the present cross-sectional study, serum 25-hydroxy vitamin D [25 (OH) D], levels which is known as an indicator of vitamin D adequacy, was examined in infants with three or more wheezing attacks. Results A total of 186 infants with recurrent wheezing were included in the study along with 118 healthy control peers. The recurrent wheezing study participants were classified into two groups according to Asthma Predictive Index (API) positivity and compared to control subjects regarding their serum vitamin D status. The API negative group had the lowest mean serum 25 (OH) D level (n = 121; 22.71 +/- 10.76 ng/ml) followed by API positive group (n = 65; 24.08 +/- 9.02 ng/ml) compared to healthy group (26.24 +/- 11.88 ng/ml) (p < 0.05). In addition, higher vitamin D deficiency was observed in infants in API negative group (52.1 %; p < 0.01) and API positive group (38.5 %; p < 0.05) than control group (31.4 %). Conclusions Low levels of 25 (OH) D were detected in infants with two different phenotypes of recurrent wheeze. Vitamin D deficiency may play a role in the pathogenesis of infants with recurrent wheezing.