Browsing by Author "Yilmaz, Meltem"

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Evaluation of Exudative Pleural Effusions: A Multicenter, Prospective, Observational Study
(2022) Ak, Guntulu; Metintas, Selma; Taskin, Ayse Naz; Sener, Melahat Uzel; Soyler, Yasemin; Yilmaz, Meltem; Turna, Akif; Kabalak, Pinar Akin; Bilaceroglu, Semra; Koksal, Deniz; Demirci, Nilgun Yilmaz; Sogukpinar, Ozlem; Boga, Sibel; Ercelik, Merve; Karadeniz, Gulistan; Polat, Gulru; Guldaval, Filiz; Akturk, Ulku Aka; Yilmaz, Senay; Ogan, Nalan; Yilmaz, Saliha; Esendagli, Dorina; Caglayan, Benan; Zeybek, Arife; Kocak, Nagihan Durmus; Mutlu, Pinar; Baytemir, Cansel Atinkaya; Mutlu, Pinar; Baytemir, Cansel Atinkaya; Sarbay, Ismail; Yilmaz, Ulku; Metintas, Muzaffer; 36173482
Purpose The aim of this study is to determine the diagnostic performances of pleural procedures in undiagnosed exudative pleural effusions and to evaluate factors suggestive of benign or malignant pleural effusions in tertiary care centers. Methods This was a multicenter prospective observational study conducted between January 1 and December 31, 2018. A total of 777 patients with undiagnosed exudative pleural effusion after the initial work-up were evaluated. The results of diagnostic procedures and the patients' diagnoses were prospectively recorded. Sensitivity, specificity, and accuracy estimates with 95% confidence intervals were used to examine the performance of pleural procedures to detect malignancy. Results The mean age +/- SD of the 777 patients was 62.0 +/- 16.0 years, and 68.3% of them were male. The most common cause was malignancy (38.3%). Lung cancer was the leading cause of malignant pleural effusions (20.2%). The diagnostic sensitivity and accuracy of cytology were 59.5% and 84.3%, respectively. The diagnostic sensitivity of image-guided pleural biopsy was 86.4%. The addition of image-guided pleural biopsy to cytology increased diagnostic sensitivity to more than 90%. Thoracoscopic biopsy provided the highest diagnostic sensitivity (94.3%). The highest diagnostic sensitivity of cytology was determined in metastatic pleural effusion from breast cancer (86.7%). Conclusion The diagnostic performance increases considerably when cytology is combined with image-guided pleural biopsy in malignant pleural effusions. However, to avoid unnecessary interventions and complications, the development of criteria to distinguish patients with benign pleural effusions is as important as the identification of patients with malignant pleural effusions.
Parametric Design as A Creation Tool for The Memory Space
(2021) Yilmaz, Meltem; Mendilcioglu, Riza Fatih
Purpose This study theoretically discusses the role of parametric design in memory-space design in contemporary architecture. Subsequently, it aims to strengthen the discussion by examining three structures with different interpretations of parametric design: namely, the Abu Dhabi Louvre Museum in the UAE with its attempt to create social and cultural memory; the Yinchuan Museum in China, which has weak ties with its past due to political reasons, trying to re-create its ancient culture with its understanding of contemporary culture; and Istanbul City Museum, which uses parametric design to present the layered structure of its local and cultural memory, are the exemplary architectural structures considered. The three structures' treatment of parametric design, their differentiations of parametric-based form creation methods, and their different ways of constructing cultural memory and space relationship through parametric methods constitutes the purpose of the research. Design/Methodology/Approach In the study, descriptive scanning method was followed, and an interview was conducted with Alper Derinbogaz, the architect of the Istanbul City Museum. Findings The findings of this study are indicated as the use of information as a source of form in creating societies' cultural memories, the opportunities for cultural and environmental adaptation, and the flexible understanding of design provided by parametric design. These were deduced in all three examples where non-Euclidian and topological forms strengthen the monumentality of the museum structures. Research Limitations/Implications It is the fact that the parametric design approach is just developing and the number of museums that have social and cultural importance in contemporary architecture may be seen as determine the limit of this study. However, the continuous increase in the number of samples may weaken this limitation. Social/Practical Implications The social and cultural effects of parametric design on the creation of memory spaces are discussed. Originality/Value This study is the first study that researching the cultural, environmental and formal harmony that parametric design provides in contemporary museum buildings.