Browsing by Author "Yilmaz, M."

Now showing 1 - 8 of 8

Adherence to Insulin Treatment in Insulin Naive Type 2 Diabetic Patients: Results of Telephonic Intervention
(2014) Yavuz, D. Gogas; Bilen, H.; Sancak, S.; Galip, T.; Hekimsoy, Z.; Sahin, I.; Yilmaz, M.; Aydin, H.; Atmaca, A.; Sert, M.; Karakaya, P.; Arpaci, D.; Oguz, A.; Guvener, N.
Antenna-Type Radiofrequency Generator in Nanoparticle-Mediated Hyperthermia
(2016) Nasseri, B.; Yilmaz, M.; Turk, M.; Kocum, I. C.; Piskin, E.
Induction of hyperthermia using nanoparticles with specific magnetic, electrical, acoustic, optical or thermal properties is a potential alternative to conventional thermal ablation in cancer therapy. In this study, for the first time we employed an antenna-type radiofrequency (RF) generator as the energy source and as a proof of concept the effects of nanoparticles of varying structures and sizes, such as super-paramagnetic iron oxide nanoparticles (SPIONs), gold-coated superparamagnetic iron oxide nanoparticles (Au@SPIONs), spherical gold nanoparticles (AuNPs), and gold nanorods (AuNRs) on RF hyperthermia were examined to determine hyperthermia efficiency of the antenna-type RF generator. In preliminary experiments, RF was applied at varying powers to various nanoparticle solutions. In all cases, temperature rises due to exposure of RF radiation to nanoparticles were captured by using an infrared thermal camera. This procedure was applied to in vitro tests of fibroblast (L-929) and breast cancer (MCF-7) cell lines. Cell viability, apoptosis and necrosis were evaluated in both cell lines to comprehensively determine cell toxicity. Due to their particle size and chemical nature, SPIONs, in the case of highest RF power and nanoparticle concentration, resulted in the lowest cell viability and highest levels of apoptosis and necrosis.
Antibiotic overconsumption and resistance in Turkey
(2019) Isler, B.; Keske, S.; aksoy, M.; Azap, O. K.; Yilmaz, M.; Yavuz, S.S.; Aygun, G.; Tigen, E.; Akalin, H.; Azap, A.; Ergonul, O.; 30844434
Assessment of Atrial Fibrillation and Ventricular Arrhythmia Risk in Patients With Asthma By P Wave/Corrected QT Interval Dispersion
(2018) Yilmaz, H. E. Bozkurt; Yilmaz, M.; Sen, N.; Altin, C.; Unsal, Z. E.; Tekin, A.; Akcay, S.; https://orcid.org/0000-0002-4171-7484; https://orcid.org/0000-0003-3225-2686; https://orcid.org/0000-0002-5658-870X; https://orcid.org/0000-0002-8360-6459; 29461607; AAI-8947-2021; AAD-5602-2021; ABD-7304-2021; AAB-5175-2021
OBJECTIVE: Although the relationship between obesity-asthma, obesity-atrial fibrillation (AF) and obesity-sudden cardiac death is clearly known, the risk of AF and ventricular arrhythmia has not been clearly determined in asthmatic patients. The aim of this study was to investigate whether AF, ventricular arrhythmia, and sudden cardiac death risk were increased in asthmatic patients using P wave dispersion (PWD) and corrected QT interval dispersion (CQTD). PATIENTS AND METHODS: The study was designed as a cross-sectional study. A total of 164 participants (88 patients with asthma and 76 healthy. volunteers) were enrolled into the study. PWD and CQTD were measured and recorded in both groups. The statistical difference between the two groups was examined. RESULTS: PWD was higher in the asthma patients than in control subjects (31.53 +/- 3.18 vs. 30.33 +/- 3.53, p = 0.023). However, there was no statistically difference between the groups in terms of CQTD measurement (43.9 +/- 1.84 vs. 43.63 +/- 2.06, p = 0.385). In comparison between control group and asthma subgroups (mild, moderate and severe), there was a statistically significant difference among these four groups in terms of PWD (p = 0.017). Subgroup analyses showed that this difference was mainly due to patients with severe asthma. CONCLUSIONS: PWD value was elevated in asthmatic compared to the control group. The CQTD was not statistically significant between the groups. These results indicate that the risk of developing AF in asthmatic patients might be higher than in the normal population. Ventricular arrhythmia and sudden cardiac death risk may not be high in asthmatic patients.
Association of Chronic Lymphocytic Leukemia and Acute Myelobastic Leukemia in Three Patients; Cases with the Concomitant Presence of Two Different Malignant Clones
(2017) Yilmaz, M.; Kizikli, A.; Yeral, M.; Kozanoglu, I.; Durusoy, S.; Subari, S.; Cangi, S.; 0000-0002-5710-5263; 0000-0002-9580-628X; 0000-0002-5268-1210; HKM-4739-2023; ABC-4148-2020; AAE-1241-2021
Evaluation of Our Drug Allergy Cases
(2015) Ozhan, Kont A.; Altintas, D. U.; Karagoz, Dogruel D.; Karakoc, Bingol G.; Duyuler, Aycin G.; Yilmaz, M.; E-7787-2018
Impact of Weight Loss on Epicardial Fat and Carotid Intima Media Thickness After Laparoscopic Sleeve Gastrectomy: A Prospective Study
(2018) Altin, C.; Erol, V; Aydin, E.; Yilmaz, M.; Tekindal, M. A.; Sade, L. E.; Gulay, H; Muderrisoglu, H.; https://orcid.org/0000-0002-3996-5681; https://orcid.org/0000-0003-3737-8595; https://orcid.org/0000-0002-0442-6178; https://orcid.org/0000-0003-0907-3647; https://orcid.org/0000-0002-9635-6313; https://orcid.org/0000-0002-2557-9579; 29571589; HGC-1839-2022; S-6973-2016; AAG-8233-2020; AAI-8276-2021; AAJ-6407-2021; AAQ-7583-2021
Background and aims: Cardiovascular disease (CVD) is one of the leading causes of mortality in obese patients. We aimed to investigate the influence of significant weight loss following laparoscopic sleeve gastrectomy (LSG) on carotid intima media thickness (CIMT) and epicardial fat thickness (EFT) which are the independent predictors of subclinical atherosclerosis. Methods and results: Patients were recruited for standard indications. A total of 105 patients (79 women and 26 men) with the mean age of 43.61 +/- 12.42 were prospectively enrolled. On Bmode duplex ultrasound; the mean CIMT at the far wall of both left and right common carotid arteries were measured. EFT was measured on the free wall of the right ventricle at enddiastole from the parasternal long-axis view by standard transthorasic 2D echocardiography. Delta (Delta) values were obtained by subtracting sixth month values from the baseline values. Body mass index (BMI) was significantly reduced from 46.95 +/- 7.54 to 33.54 +/- 6.41 kg/m2 (p < 0.001) in sixth months after LSG. Both EFT and CIMT were significantly decreased after surgery (8.68 +/- 1.95 mm vs. 7.41 +/- 1.87 mm; p < 0.001 and 0.74 +/- 0.13 mm vs. 0.67 +/- 0.11 mm; p < 0.001 respectively). A significant correlation between Delta EFT and Delta MI (r = 0.431, p < 0.001) was shown. Delta CIMT is significantly correlated with Delta EFT, Delta BMI and Delta systolic blood pressure (r = 0.310, r = 0.285 and r = 0.231 respectively, p < 0.05 for all). In multivariate stepwise linear regression analysis; among variables only Delta BMI was the independent predictor of Delta EFT (beta = 153, p = 0.001). Conclusion: Early atherosclerotic structural changes may be reversed or improved by sustained weight loss after LSG in asymptomatic obese patients. (C) 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Relationship between Neutrophil-to-Lymphocyte Ratio and Impaired Myocardial Perfusion in Cardiac Syndrome X
(2015) Okyay, K.; Yilmaz, M.; Yildirir, A.; Eroglu, S.; Sade, E.; Sahinarslan, A.; Aydinalp, A.; Muderrisoglu, H.; 0000-0001-8750-5287; 0000-0001-6134-8826; 0000-0002-3761-8782; 0000-0002-9635-6313; 0000-0003-3737-8595; 0000-0003-3055-7953; 26044235; A-4947-2018; AAK-7355-2020; AAD-5841-2021; ABG-1582-2021; AAG-8233-2020; AAQ-7583-2021
OBJECTIVE: Myocardial tissue perfusion is decreased in patients with cardiac syndrome X (CSX). Systemic inflammation appears to be an important contributor to the diseased microvascular network of these patients. The neutrophil-to-lymphocyte ratio (NLR) is a surrogate marker of inflammation. Accordingly, we evaluated this biomarker concerning the microvascular circulation of CSX patients. PATIENTS AND METHODS: This study included 60 consecutive patients (54.1 +/- 7.8 years of age, 49 females) with CSX (typical chest pain, positive exercise stress test results, and normal coronary angiograms) and 60 consecutive age- and sex-matched control subjects. In all coronary territories, epicardial coronary flow was assessed by the Thrombolysis In Myocardial Infarction frame count (TFC) method, and myocardial tissue perfusion was assessed by the myocardial blush grade (MBG) method. Normal myocardial perfusion was accepted as an MBG score of 3 in all coronary territories. RESULTS: Patients with CSX had higher NLRs than those of control subjects (1.98 +/- 0.77 vs 1.72 +/- 0.55, respectively; p = 0.04). Among patients with CSX, those with impaired myocardial perfusion had higher NLRs than those with normal myocardial perfusion (2.13 +/- 0.82 vs 1.71 +/- 0.59, respectively; p = 0.028). There was a negative correlation between the NLR and total MBG score (p = 0.027, r = -0.29). Logistic regression analysis showed that the NLR was an independent and negative predictor of myocardial tissue perfusion (p = 0.027; Beta, -1.057; odds ratio, 2.878; 95% confidence interval, 1.129-7.335). CONCLUSIONS: Patients with CSX have high NLRs, and inflammation seems to be associated with distorted myocardial perfusion in these patients.