Browsing by Author "Yilmaz, I."

Now showing 1 - 4 of 4

Comparison of the effects of intravenous Dexketoprofen Trometamol versus Paracetamol on postoperative analgesia in patients undergoing Septoplasty: A randomised double-blind clinical trial
(2018) Caliskan, Esra; Sener, M.; Kipri, M.; Yilmaz, I.; Aribogan, A.; 0000-0001-6497-0610; 30034413
Background and Objective: Septoplasty operations are associated with moderate to severe postoperative pain which has unfavourable effects on patient's recovery and postoperative outcome. The aim of this study was to compare effects of intravenous paracetamol and dexketoprofen on postoperative analgesia, tramadol consumption and side effects after septoplasty. Methods: In total 72 patients (aged 18-65 years) who had undergone an elective septoplasty from August 2013 to January 2015 in Baskent University Faculty of Medicine, in the Department of Anesthesiology and Reanimation Clinics were included in this study. The patients were randomised into one of two groups: those who received intravenous paracetamol; and those who received intravenous dexketoprofen. All patients were treated with tramadol for 24 hour postoperatively. The primary endpoint was pain intensity as measured by a visual analogue scale (VAS). Tramadol consumption and drug related side effects were also recorded. Results: The pain scores in the dexketoprofen group were significantly lower at recovery, 15 and 30 minutes and two hour (p< 0.05). The pain scores had no difference at other time points. Tramadol consumption in the recovery period was significantly lower in the dexketoprofen group, but cumulative tramadol consumption did not differ between the groups. The incidence of nausea was lower but not statistically significant in the dexketoprofen group at 15 and 30 minutes and two hour. Conclusions: Compared with paracetamol, preemptive dexketoprofen is associated with lower VAS scores and tramadol consumption in the early postoperative period after septoplasty. However, the cumulative tramadol consumption did not significantly differ between the groups.
Evaluation of vascular endothelial growth factor-A and Endostatin levels in induced sputum and relationship to bronchial hyperreactivity in patients with persistent allergic rhinitis monosensitized to house dust
(2015) Yilmaz, I.; Bayraktar, N.; Ceyhan, K.; Secil, D.; Yuksel, S.; Misirligil, Z.; Bavbek, S.; 26051834
Background: Studies about the pathogenesis of bronchial hyperreactivity (BHR) in patients with persistent allergic rhinitis (PAR) and its relationship with lower airway remodeling are extremely limited. Objective: This study evaluated bronchial vascular remodeling via the measurement of angiogenic factor, vascular endothelial growth factor-A (VEGF-A), and anti-angiogenic factor, Endostatin, and evaluated their relationship with BHR in patients with PAR. Methods: The study group consisted of 30 patients with PAR monosensitized to house dust mites and 14 non-allergic healthy controls. All subjects underwent induced sputum and methacholine (M) bronchial provocation tests. VEGF-A and Endostatin levels were measured by ELISA in induced sputum supernatants. Results: The percentages of eosinophils in induced sputum were significantly increased in patients with PAR compared with healthy controls. There were no significant differences between patients with PAR and healthy controls in terms of levels of VEGF (37.9 pg/ml, min-max: 5-373 pg/ml vs. 24.9, min-max: 8-67 pg/ml, p = 0.8 respectively), Endostatin (532.5 pg/ml, min-max: 150-2125 pg/ml vs. 644, min-max: 223-1123 pg/ml, p = 0.2 respectively) and VEGF/Endostatin ratio (0.057 vs. 0.045, p = 0.8 respectively). In addition, there were no significant differences between patients who are BHR positive (n = 8), or negative to M (n = 22) in terms of levels of VEGF, Endostatin and VEGF/Endostatin ratio and no correlations among value of PD20 to M and levels of VEGF, Endostatin and VEGF/Endostatin ratio. Conclusion: We conclude that VEGF-A and Endostatin did not differ between patients with PAR and healthy controls regardless of BHR to M. (C) 2014 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L.U. All rights reserved.
Neuronal regeneration in injured rat spinal cord after human dental pulp derived neural crest stem cell transplantation
(2018) Kircelli, Ali; Yilmaz, Cem; Kabatas, S.; Demir, C.S.; Civelek, E.; Yilmaz, I.; Akyuva, Y.; Karaoz, E.; 0000-0003-2109-1274; 29536742
OBJECTIVE: This study aimed to analyze the effect of human Dental Pulp-Neural Crest Stem Cells (hDP-NCSCs) delivery on lesion site after spinal cord injury (SCI), and to observe the functional recovery after transplantation. METHODS: Neural Crest Stem Cells (NCSCs) were isolated from human Dental Pulp (hDP). The experimental rat population was divided into four groups (n = 6/24). Their behavioral motility was scored regularly. After 4-weeks, rats were sacrificed, and their spinal cords were examined for Green Fluorescent Protein (GFP) labeled hDP-NCSCs by immunofluorescence (IF) staining. RESULTS: In early post-injury (p.i) period, the ultrastructure of spinal cord tissue was preserved in Group 4. The majority of cells forming the ependymal region around the central canal were found to be hDP-NCSCs. While the grey-and-white-matter around the ependymal region was composed of e.g. GFP cells, with astrocytic-like appearance. The scores showed significant motor recovery in hind limb functions in Group 4. However, no obvious change was observed in other groups. C ONCLUSION: Cells e.g., mesenchymal (Vimentin+) which express GFP+ cells in the gray-and-white-matter around the ependymal region could indicate the potential to self-renewal and plasticity. Thus, transplantation of hDP-NCSCs might be an effective strategy to improve functional recovery following spinal cord trauma (Fig. 10, Ref. 32). Text in PDF www.elis.sk.
Segmental Superficial Parotidectomy in The Surgical Treatment of Benign Parotid Tumours
(2018) Eski, E.; Sokmen, M. F.; Yilmaz, I.; https://orcid.org/0000-0002-4784-3342; https://orcid.org/0000-0002-1694-7608; 29463342; AAD-5458-2021; AAJ-2992-2021
Objective: To evaluate the efficacy and safety of segmental superficial parotidectomy in the surgical treatment of benign parotid tumours. Methods: Patients who underwent parotidectomy for benign primary parotid tumours limited to the superficial lobe were retrospectively reviewed. Tumour location, size, surgical procedure, follow-up period, complications and recurrence rates were noted. Results: The study included a total of 39 patients: 22 underwent segmental superficial parotidectomy (group 1) and 17 underwent superficial parotidectomy (group 2). The mean follow-up period was 41.79 months (range, 13-85 months). There were no recurrences in either group during the follow-up period. No significant differences were found between the two groups in terms of tumour size, complications or recurrence rates. Conclusion: Segmental superficial parotidectomy is a safe and effective option in the surgical treatment of benign parotid tumours.