Browsing by Author "Yilmaz, Huriye Erbak"

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Efficacy of Ultrasound Guided Platelet-Rich Plasma in The Repair of Partial and Full-Thickness Supraspinatus Tears
(2019) Akan, Ozlem; Mete, Berna Dirim; Kocyigit, Hikmet; Bayram, Korhan Baris; Yilmaz, Huriye Erbak; Tosun, Aliye; https://orcid.org/0000-0002-5054-5784; HLG-9611-2023
Background: Rotator cuff tears [RCT] are one of most common shoulder pain causes. Some patients do not give response to conservative treatments and patients couldn't get sufficient recovery after the surgery. Ultrasound guided platelet-rich plasma [PRP] administration may decreases the RCT sourced pains and improves functional abilities in patients with partial and complete rotator cuff tear. In this control group included study, the effectiveness of PRP treatment on RCT's has been revealed. Methods: In this randomized controlled clinical trial, the study included 90 patients who were randomized to four groups as: partial tear PRP, partial tear control, complete tear PRP and complete tear control. One cc PRP was obtained from 20 cc blood samples of patient, after double centrifuged at 400 g for 10 minutes. Under musculoskeletal ultrasound guidance, the PRP groups were given 3 injections of PRP in the affected shoulder at 3-week intervals. All groups were given a home exercise program 3 times per week. The range of motion, Quick DASH, Shoulder Pain and Disability Index [SPADI], Constant and VAS scores were used for the evaluation of patients at 3, 6 and 9 weeks, and 3, 6 and 12 months for follow-up visits. Results: In all groups, statistically significant improvements were observed in ROM, Quick DASH, SPADI, Constant and VAS scores [P < 0.05] at 12 months. Compared to control groups, more prominent improvements in all these clinical parameters were seen in PRP groups [P < 0.001]. It was also observed that the improvements seen after their first injection in PRP patients had persisted at 12 months. There was no significant difference in their improvements in these clinical parameters between PRP injected patients with partial RC tear and PRP injected patients with complete RC tear. Conclusion: We found significant and sustained improvement in pain and functional outcomes in PRP treated patients with RC tear. Our results suggest that PRP is the powerful treatment option in both patients with partial and complete RC tear and it may be an alternative approach before surgery in patients that do not benefit from conservative treatments.
Gingival crevicular fluid semaphorin 4D and peptidylarginine deiminase-2 levels in periodontal health and disease
(2019) Veysioglu, Gozde; Savran, Levent; Narin, Figen; Yilmaz, Huriye Erbak; Avsar, Candeger; Saglam, Mehmet; 31025704
Background The aim of this study was to compare the levels of semaphorin 4D (SEMA4D), peptidylarginine deiminase 2 (PAD2) and matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF) in patients with periodontal disease and patients with healthy periodontium and investigate the effects of periodontal treatment on the levels of these molecules. Methods GCF samples were collected from periodontally healthy controls (C group, n = 20), patients with gingivitis (G group, n = 20), and patients with chronic periodontitis (CP group, n = 20). Sampling sites were also divided into bleeding (BP) and non-bleeding (NBP) periodontal pocket groups in CP group. Full-mouth clinical periodontal parameters were also recorded. GCF samplings and clinical records were also repeated at 1 and 3 months after treatment for the CP group. SEMA4D, PAD2, and MMP-8 levels were determined by enzyme-linked immunosorbent assay. Results The GCF SEMA4D, PAD2, and MMP-8 total amounts were similar in CP and G groups (P > 0.05) but significantly greater than the C group (P < 0.05). The GCF SEMA4D and PAD2 total amounts in the BP group were significantly greater than the NBP group (P < 0.05). GCF MMP-8 total amounts were similar in BP and NBP groups (P > 0.05). The GCF SEMA4D, PAD2, and MMP-8 total amounts were significantly reduced at first month after treatment (P < 0.05). There were positive correlations between GCF total amount of SEMA4D and all clinical parameters (P < 0.01) and also between PAD2 and clinical parameters (P < 0.05) except clinical attachment level. There was a positive correlation between GCF total amount of SEMA4D and GCF total amount of MMP-8 (P < 0.05). Conclusions It may be suggested that SEMA4D and PAD2 are related to periodontal disease. Their GCF total amounts may have a diagnostic potential. Additional studies would better clarify their role in periodontal diseases.