Browsing by Author "Yilmaz, Busra"

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    Comment on: Osteoradionecrosis after postoperative radiotherapy for oral cavity cancer: A retrospective cohort study
    (2022) Topkan, Erkan; Somay, Efsun; Yilmaz, Busra; Kucuk, Ahmet; 0000-0003-0633-5648; 36041356
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    Comment on: Required Time for Pre-Oncological Dental Management-A Rapid Review of the Literature
    (2022) Topkan, Erkan; Somay, Efsun; Yilmaz, Busra; Kucuk, Ahmet; 0000-0001-8120-7123; 0000-0003-0633-5648; 36183502; AAG-2213-2021; AAR-6904-2020
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    Comparative Analysis of Different Periapical Index Systems Used in Cone-Beam Computed Tomography
    (2021) Sisli, Selen Nihal; Yilmaz, Busra; Ozpolat, Zeynep; Gulsahi, Kamran; 0000-0003-0633-5648; 0000-0003-3510-7265; 33547741; AAX-5565-2021
    This study aimed to compare the three index systems designed for cone-beam computed tomography (CBCT) in terms of intra- and inter-observer agreement. 117 root-filled teeth with or without periapical radiolucency from 77 of already existing CBCT images were chosen randomly. Two observers evaluated the periapical status of the selected teeth and graded the scores twice using CBCT periapical index (CBCTPAI), endodontic radiolucency index (ERI) and complex periapical index (COPI) part of the periapical and endodontic status scale (PESS), respectively. The researchers' self-agreement kappa values ranged from substantial to almost perfect. A moderate inter-observer agreement was present for the COPI and ERI, whereas a fair agreement was present for CBCTPAI. The researchers' ICC for the inter-observer reliability of CBCTPAI, ERI and COPI was 0.75, 0.77 and 0.80, respectively. COPI had the highest self-agreement and inter-observer reliability. ERI showed the highest intra-observer variation, whereas CBCTPAI showed the highest inter-observer variation.
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    Confirming the diagnosis of temporomandibular joint disorder by magnetic resonance imaging
    (2020) Yilmaz, Busra; Somay, Efsun
    Purpose: The aim of this study was to define the temporomandibular joint complaints of patients with different genders and educational levels and to investigate the accuracy of these complaints with the diagnosis of temporomandibular joint disorder (TJD) with magnetic resonance imaging (MRII). Material and Methods: Temporomandibular joint MRI and clinical examination findings and panoramic radiographs of 99 patients over 18 years of age who applied to the dental clinic between 2011-2018 with the complaint of jaw pain and limited mouth opening are evaluated. The cases which TJD was determined as a result of MRI, are accepted as MRI (+). The ones with the complaints of TJD, but the joint was within normal limits in the MRI, MRI is recorded as (-). Results: There is significant correlation between MRI results and gender but no correlation between MRI results and tooth loss. It is found education level did not have significant effect on the described joint complaints and MRI (+) findings. Conclusion: Women describe temporomandibular joint problems better than men. Even if the level of education is high, patients may not be able to convey their complaints correctly to the physician. Clinical findings should be supported by MRI results in order to diagnose this disease.
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    Hemoglobin-to-platelet ratio in predicting the incidence of trismus after concurrent chemoradiotherapy
    (2023) Somay, Efsun; Yilmaz, Busra; Topkan, Erkan; Kucuk, Ahmet; Haksoyler, Veysel; Pehlivan, Berrin; Selek, Ugur; Araz, Kenan; 0000-0003-0633-5648; 0000-0001-8120-7123; 36038508; AAG-2213-2021
    Objective The significance of pre-hemoglobin-to-platelet ratio (HPR) in predicting the occurrence of radiation-induced trismus (RIT) in locally advanced nasopharyngeal carcinoma patients (LA-NPC) who received concurrent chemoradiotherapy (C-CRT). Methods The records of LA-NPC patients with oral examination before and after C-CRT were analyzed. Maximum mouth openings (MMO) were measured before and after C-CRT to confirm RIT status, with an MMO of <= 35 mm defined as RIT. HPR values were calculated on the first day of C-CRT. The relationship between the HPR values and RIT status was discovered using the receiver operating characteristic curve analysis. Results A total of 43 patients RIT cases among 198 individuals were diagnosed. The optimal HPR cutoff that stratified the patients into two groups was 0.54. RIT incidence was found to be significantly higher in the HPR <= 0.54 group than its HPR >0.54 counterpart(p < 0.001). Univariately T3-4 stage, mean masticator apparatus dose>57.2Gy, and pre-C-CRT MMO <= 40.7 mm were found as the other significant correlates of increased RIT rates(p < 0.05). All four variables seemed to be independently connected to greater RIT incidence in multivariate analysis (p < 0.05, for each). Conclusion The risk of post-C-CRT RIT may be significantly increased when pre-treatment HPR levels are low.
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    High pretreatment systemic immune-inflammation index values are associated with diminished short-term success after temporomandibular joint arthrocentesis procedure
    (2021) Somay, Efsun; Yilmaz, Busra; 0000-0003-0633-5648; 0000-0001-8251-6913; 34654426
    Background The systemic immune-inflammation index (SII) has been demonstrated to be a valid biomarker of a patient's immunological and inflammatory state, with the ability to accurately predict outcomes in a variety of disease conditions. In the absence of comparable studies, we intended to examine the relevance of pretreatment SII in predicting the success rates of temporomandibular joint arthrocentesis (TMJA) at 1-week, 1-month, and 6-month periods, defined as maximum mouth opening (MMO) > 35 mm and VAS <= 3. Methods A sum of 136 patients with disc displacement without reduction (DDwo-red) who underwent TMJA was included. For each patient, pre-TMJA SII was calculated as; SII = Platelets x neutrophils/lymphocytes. Additionally, baseline MMO and VAS measurements were recorded for each patient. The success criteria of TMJA included MMO > 35 mm and VAS <= 3. The optimal pre-TMJA SII cutoff that predicts TMJA success was determined using receiver operating characteristic (ROC) curve analysis. The primary endpoint was the link between the pre-treatment SII and TMJA success (simultaneous achievement of MMO > 35 mm and VAS <= 3). Results The median pre-TMJA jaw locking duration, maximum mouth opening (MMO), and visual analog score (VAS) were 7 days, 24 mm, and 8, respectively. The overall TMJA success rates were determined as 80.1%, 91.9%, and 69.1% at 1-week, 1-month, and 6-months, respectively. The results of ROC curve analysis exhibited the optimal SII cutoff at 526 (AUC: 67.4%; sensitivity: 66.7%; specificity: 64.2%) that grouped the patients into two subgroups: Group 1: SII <= 526 (N = 81) and SII > 526 (N = 55), respectively. Spearman correlation analysis revealed a strong inverse relationship between the pretreatment SII values and the success of TMJA 1-week (r(s): - 0.83; P = 0.008) and 1-month, (r(s): - 0.89; P = 0.03). Comparative analyses displayed that TMJA success rates at 1-week (87.7% vs. 69.1%; P = 0.008) and 1-month (96.2% vs. 80%; P = 0.03) were significantly higher in the SII <= 526 than SII > 526 group, respectively, while the 6-month results favored the SII <= 526 group with a trend approaching significance (P = 0.084). Conclusion The current study's findings suggested the SII as a unique independent prognostic biomarker that accurately predicts treatment outcomes for up to 6 months. Trial registration The results of this research were retrospectively registered.
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    In reply to Shih YJ et.al. (doi: 10.1111/odi.14349)
    (2022) Topkan, Erkan; Somay, Efsun; Yilmaz, Busra; 0000-0001-8120-7123; 0000-0003-0633-5648; 36114821; AAG-2213-2021
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    In Reply to Wang et al. (doi: 10.1111/odi.14391)
    (2022) Somay, Efsun; Yilmaz, Busra; 36398473
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    Initial neutrophil-to-lymphocyte ratio predicts radiation-induced trismus in parotid gland cancer
    (2023) Somay, Efsun; Yilmaz, Busra; Topkan, Erkan; Kucuk, Ahmet; Pehlivan, Berrin; Selek, Ugur; 0000-0001-8120-7123; 36349491; AAG-2213-2021
    ObjectiveTo investigate the link between pretreatment neutrophil-to-lymphocyte ratio(NLR) and the incidence of radiation-induced trismus(RIT) in parotid gland cancers(PGC) patients after postoperative radiotherapy(PORT). MethodData of PGC patients who had oral examinations before and after PORT were reviewed retrospectively. We comprised patients who had maximum mouth opening (MMO) assessments before and after PORT and complete blood count test on the first day of PORT. MMO of <= 35 mm was considered as RIT. The receiver operating characteristic (ROC) curve analysis was used to search for an ideal NLR threshold value that might be linked to RIT rates. ResultsFifty-one patients were included, with a RIT incidence of 15.7%. The NLR cutoff that showed a link with the prevalence of RIT in the ROC curve analysis was 2.7[Area under the curve (AUC):82.0%; sensitivity:87.5%; specificity:74.4%]. The patients were divided into groups based on this value:Group 1: NLR <= 2.7 (N = 34) and;NLR >2.7 (N = 17). In comparative analysis, the incidence of RIT was found to be statistically higher in the NLR >2.7 than counterpart (35.2%vs.5.8%;r(s):0.79; p < .001). Also, a mean temporomandibular joint dose >= 51.0Gy was linked to increased RIT rates (p < .001). ConclusionThis study showed that high pre-PORT NLR levels were a robust and independent predictor of significantly elevated rates of RIT.
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    Is obesity a problem that threatens oral health in adults?
    (2021) Yilmaz, Busra; Somay, Efsun; 0000-0003-0633-5648
    Purpose: Obesity is one of the increasingly negative factors affecting oral and dental health directly or indirectly in many developed and developing countries. The aim of this study was to determine the relationship between obesity and dental problems in adults and to investigate the effect of obesity on oral and dental health. Materials and Methods: 200 patients over the age of 18 who applied with various dental complaints were examined clinically and radiologically. They were classified as 50 healthy females, 50 healthy males, 50 obese females, and 50 obese males according to the body mass index determined by the World Health Organization (healthy individual < 30.0 kg / m(2) and 30.0 kg / m(2) <= obesity individual). Sociodemographic characteristics, dental health status, and data of all patients were examined. Results: A statistically significant relationship was found between obesity and the number of tooth loss, the number of dental caries, educational status, and the frequency of applying to the dentist. Periodontitis was detected at a higher rate in the obesity group (58 %) compared to the control group, but the relationship between obesity and periodontal status was not statistically significant. Conclusion: Dental problems such as tooth loss, the number of dental caries, and periodontitis were higher in the obesity group, and this result showed that obesity threatens oral and dental health. To prevent these problems, there is a need for preventive strategies and increasing awareness of oral and dental health in obese patients.
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    Letter to The Editor: To Extract or Not Extract Teeth Prior to Head and Neck Radiotherapy?
    (2023) Yilmaz, Busra; Somay, Efsun; Topkan, Erkan; https://orcid.org/0000-0003-0633-5648; https://orcid.org/0000-0001-8251-6913; https://orcid.org/0000-0001-8120-7123; 36576606; AAR-6904-2020; AAG-2213-2021
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    Predicting Teeth Extraction after Concurrent Chemoradiotherapy in Locally Advanced Nasopharyngeal Cancer Patients Using the Novel GLUCAR Index
    (2023) Somay, Efsun; Topkan, Erkan; Yilmaz, Busra; Besen, Ali Ayberk; Mertsoylu, Huseyin; Selek, Ugur; 0000-0001-8120-7123; 0000-0001-8251-6913; 38066835; AAG-2213-2021
    To evaluate the value of the newly created GLUCAR index in predicting tooth extraction rates after concurrent chemoradiotherapy (C-CRT) in locally advanced nasopharyngeal carcinomas (LA-NPCs). Methods: A total of 187 LA-NPC patients who received C-CRT were retrospectively analyzed. The GLUCAR index was defined as 'GLUCAR = (Fasting Glucose x CRP/Albumin Ratio) by utilizing measures of glucose, C-reactive protein (CRP), and albumin obtained on the first day of C-CRT. Results: The optimal GLUCAR cutoff was 31.8 (area under the curve: 78.1%; sensitivity: 70.5%; specificity: 70.7%, Youden: 0.412), dividing the study cohort into two groups: GLUCAR < 1.8 (N = 78) and GLUCAR >= 31.8 (N = 109) groups. A comparison between the two groups found that the tooth extraction rate was significantly higher in the group with a GLUCAR >= 31.8 (84.4% vs. 47.4% for GLUCAR < 31.8; odds ratio (OR):1.82; p < 0.001). In the univariate analysis, the mean mandibular dose >= 38.5 Gy group (76.5% vs. 54.9% for <38.5 Gy; OR: 1.45; p = 0.008), mandibular V55.2 Gy group >= 40.5% (80.3 vs. 63.5 for <40.5%, p = 0.004, OR; 1.30), and being diabetic (71.8% vs. 57.9% for nondiabetics; OR: 1.23; p = 0.007) appeared as the additional factors significantly associated with higher tooth extraction rates. All four characteristics remained independent predictors of higher tooth extraction rates after C-CRT in the multivariate analysis (p < 0.05 for each). Conclusions: The GLUCAR index, first introduced here, may serve as a robust new biomarker for predicting post-C-CRT tooth extraction rates and stratifying patients according to their tooth loss risk after treatment.
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    Pretreatment Masseter Muscle Volume Predicts Survival in Locally Advanced Nasopharyngeal Carcinoma Patients Treated with Concurrent Chemoradiotherapy
    (2023) Pehlivan, Umur Anil; Somay, Efsun; Yilmaz, Busra; Besen, Ali Ayberk; Mertsoylu, Huseyin; Selek, Ugur; Topkan, Erkan; 0000-0001-5871-0695; 0000-0001-8251-6913; 0000-0001-8120-7123; 37959329; AAG-2213-2021
    Background and purpose: Muscle loss is a significant indicator of cancer cachexia and is associated with a poor prognosis in cancer patients. Given the absence of comparable studies, the current retrospective study sought to examine the correlation between the total masseter muscle volume (TMMV) before treatment and the survival outcomes in locally advanced nasopharyngeal cancer (LA-NPC) patients who received definitive concurrent chemoradiotherapy (CCRT). Methods: A three-dimensional segmentation model was used to determine the TMMV for each patient by analyzing pre-CCRT magnetic resonance imaging. The optimal TMMV cutoff values were searched using receiver operating characteristic (ROC) curve analyses. The primary and secondary endpoints were the relationship between the pre-CCRT TMMV measures and overall survival (OS) and progression-free survival (PFS), respectively. Results: Ninety-seven patients were included in this study. ROC curve analyses revealed 38.0 cc as the optimal TMMV cutoff: <= 38.00 cc (n = 42) and >38.0 cc (n = 55). Comparisons between the two groups showed that the TMMV>38.0 cc group had significantly longer PFS [Not reached (NR) vs. 28; p < 0.01] and OS (NR vs. 71; p < 0.01) times, respectively. The results of the multivariate analysis demonstrated that the T-stage, N-stage, number of concurrent chemotherapy cycles, and TMMV were independent associates of PFS (p < 0.05 for each) and OS (p < 0.05 for each) outcomes, respectively. Conclusion: The findings of the current retrospective research suggest that pretreatment TMMV is a promising indicator for predicting survival outcomes in LA-NPC patients receiving definitive CCRT.
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    Pretreatment Systemic Immune-Inflammation Index Predict Needs for Teeth Extractions for Locally Advanced Head and Neck Cancer Patients Undergoing Concurrent Chemoradiotherapy
    (2021) Yilmaz, Busra; Somay, Efsun; Topkan, Erkan; 0000-0001-8120-7123; 0000-0001-8087-3140; 0000-0001-8251-6913; 34703240; AAG-2213-2021
    Background: To evaluate the utility of pretreatment systemic immune-inflammation index (SII) in predicting the teeth caries and need for tooth extraction after concurrent chemoradiotherapy (C-CRT) for locally advanced squamous-cell head and neck cancer (LASCHNC) patients. Methods: The records of LA-SCHNC patients who underwent formal dental evaluations at pre and post-C-CRT periods were retrospectively analyzed. The pretreatment SII values were calculated using the platelet, neutrophil, and lymphocyte measures acquired on the first day of C-CRT: SII=Plateletsxneutrophils/lymphocytes. Receiver operating characteristic (ROC) curve analysis was employed to identify the ideal pre-C-CRT SII cutoff that may predict the teeth caries and the need for tooth extraction after the C-CRT. The primary endpoint was the link between the pre-C-CRT SII and the need for tooth extraction during the follow-up period. Results: A sum of 126 patients were included. Median follow-up was 4.9 years (range: 2.7-7.8). Nasopharyngeal and laryngeal cancers comprised the majority (75.4%) study cohort. Posttreatment teeth extractions were reported in 62.7% patients. The optimal cutoff was 558 [Area under the curve (AUC): %76.8 sensitivity: 72.3%; and specificity: 70.9%] that grouped the patients into two subgroups with significantly different post-C-CRT tooth extraction rates: Group 1: SII<558 (n = 70) and SII>558 (n = 56), respectively. Correlation analysis revealed a significant relationship between the pretreatment SII and the tooth extraction rates after the C-CRT (rs:0.89: P = 0.001). The comparative analysis displayed that the teeth extractions rates were significantly higher in the SII>558 group (77.1% versus 51.4% for SII<558; Hazard ratio: 1.68; P = 0.001). Further analyses showed that the pre-C-CRT SII>558 was the unique factor associated with meaningfully higher necessities for post-C-CRT teeth extractions. Conclusion: The present outcomes intimated that high pretreatment SII levels were linked to significantly increased post-treatment teeth extractions in LA-SCHNC patients undergoing definitive C-CRT.
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    Radiation Therapy for Ct1-2 Carcinoma of the Palatine Tonsil Diagnosed Via A Simple Tonsillectomy: Dosimetry and Patterns of Care in the IMRT Era
    (2023) Topkan, Erkan; Somay, Efsun; Yilmaz, Busra; 0000-0001-8120-7123; 37804565; AAG-2213-2021
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    A Rare Case of Burkitt Lymphoma in a 13-year-girl
    (2021) Yilmaz, Busra; Somay, Efsun; Hasbay, Bermal; orcid.org/0000-0003-0633-5648; orcid.org/0000-0001-8251-6913
    Burkitt lymphoma is rare Non-Hodgkin's lymphoma type in childhood. The differential diagnosis includes dental infection and osteomyelitis. Therefore, patients often refer to the dentist first. Early diagnosis has great importance on prognosis. We aimed to broaden the perspective of dentists about this disease and confirm the diagnosis radiographically and clinically.