Browsing by Author "Yiğit, Fatma"

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The Effects of Cinacalcet Treatment on Bone Mineral Metabolism, Anemia Parameters, Left Ventricular Mass Index and Parathyroid Gland Volume in Hemodialysis Patients with Severe Secondary Hyperparathyroidism
(2016) Torun, Dilek; Yildiz, Ismail; Micozkadioglu, Hasan; Nursal, Gul Nihal; Yiğit, Fatma; Ozelsancak, Ruya; 26787561
The aim of this study was to investigate the effects of cinacalcet therapy on anemia parameters, bone mineral metabolism, left ventricular mass index (LVMI) and parathyroid gland volume in hemodialysis (HD) patients with secondary hyperparathyroidism. Twenty-five HD patients (M/F: 11/14, mean age: 45.2 +/- 17.9 years, mean HD duration: 96.4 +/- 32.7 months) were included in this prospective pilot study. The indication to start calcimimetic therapy was persistent serum levels of parathyroid hormone (PTH) > 1000 pg/mL, refractory to intravenous (i.v.) vitamin D and phosphate-binding therapy. The initial and one-year results of adjusted serum calcium (Ca+2), phosphate (P), Ca x P product, PTH, hemoglobin (Hb) and ferritin levels, transferrin saturation index (TSAT), median weekly erythropoietin (EPO) dose, LVMI, and parathyroid volume by parathyroid ultrasonography were determined. There were no differences between pre-and posttreatment levels of serum Ca+2 (P = 0.853), P (P = 0.447), Ca x P product (P = 0.587), PTH (P = 0.273), ferritin (P = 0.153) and TSAT (P = 0.104). After 1 year of calcimimetic therapy, the Hb levels were significantly higher than the initial levels (P = 0.048). The weekly dose of EPO decreased with no statistical significance. The dose of cinacalcet was increased from 32.4 +/- 12.0 to 60.0 +/- 24.4 mg/day (P = 0.01). There were no differences between the pre-and post-treatment results regarding weekly vitamin D dose, parenteral iron dose, LVMI and parathyroid volume. The results of our study suggest that cinacalcet therapy might have an additional benefit in the control anemia in HD patients.
Psychiatric factors associated with normal coronary angiography among angina like chest pain patients
(2016) Alttinbas, Ebru; Yiğit, Fatma
Purpose: This psychiatric and cardiological study aim to compared patients with normal coronary angiography and coronary hearth disease patients with respect to sociodemografic features, psychiatric comorbidities, anxiety and depression level, mental and physical quality of life. We also determined associated factors with normal coronary patients. Material and Methods: Eighty-seven patients with normal coronary angiography (NCA) and thirty-one coronary artery disease (CAD) patients were included the study after coronary angiography. Groups were compared with regard to sociodemographic characteristics, comorbid psychiatric disorders and Beck Anxiety (BAI) and Beck Depression (BDI) Inventories and Health Related Quality of Life (SF-36) scale scores. Results: There was statistically significant difference between the groups in terms of age, gender, marital status, occupation, family history for psychiatric disorders. Mental disorders were found in 82.8% of the patients with NCA and in 48.1% of the patients with angiographic coronary disease. The patients with NCA have a higher prevalence of psychiatric comorbidity, family history of psychiatric disorder, are relatively young, female and unmarried. There was significant difference in pain, general health and social function subgroups of quality of life scale between groups. The impact of mental and physical quality of life with NCA patients were as significant as those with CAD. Conclusion: The present study revealed that prevalence of psychiatric co morbidities is high and impairment in quality of life is notable in the patients with NCA patients.