Browsing by Author "Yerdelen, Deniz"

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The Effects of Hyperventilation on Axonal Excitability Parameters in Patients with Diabetes Mellitus and Polyneuropathy
(2016) Akca, Gokcen; Yerdelen, Deniz; Balci, Mustafa Kemal; Uysal, Hilmi; 0000-0002-6063-377X; 0000-0001-6799-5100; 0000-0002-6494-3249; 27368063; C-3651-2016; AAE-7933-2021; C-2979-2016
Aims: We aimed to explore axonal excitability parameters in patients with diabetes mellitus (DM) and polyneuropathy (PNP) as well as those without PNP. Methods: We used the short TROND protocol by QTRAC to measure axonal excitability parameters (strength-duration time constant (SDTC), rheobase, etc.) in 12 healthy subjects and 14 DM patients with PNP and 10 DM patients without PNP. The short TROND protocol was performed before and after 20 min of deep hyperventilation in healthy subjects and patients with DM. Also, venous blood pH and partial pressure of O-2 and CO2 were recorded before hyperventilation (HPV) and after 20 min of HPV. A "hyperventilation score" was evaluated before and after HPV. Results: When the values of DM with PNP group and control group before HPV were compared, SDTC and latency were statistically significant. Comparing the values of the excitability parameters after HPV showed statistically significant changes in the SDTC, rheobase, and refractoriness at 2.5 ms in controls and DM patients without PNP. HPV resulted in no changes in SDTC in DM patients with PNP. Conclusion: The results of this study suggest that patients with DM and healthy subjects have different responses to HPV, and pH changes have different effects on diabetic PNP compared with healthy controls and DM patients without PNP. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
The Effects of Valproic Acid and Carbamazepine on Strength-Duration Properties of Peripheral Nerve
(2014) Yerdelen, Deniz; Koc, Filiz; https://orcid.org/0000-0001-6799-5100; 24419444; AAE-7933-2021
Objective: To study strength-duration properties of motor and sensory axons to evaluate whether there is a change in current through the persistent sodium (Na+) channels of sensory and motor axons in peripheral nerves of epileptic patients before and after valproic acid (VPA) and carbamazepine (CBZ) treatment due to the presence of similar channels in the CNS and peripheral nervous system (PNS). Methods: This study, conducted in Baskent University Faculty of Medicine, Adana, Turkey from January 2011 to February 2012, involved 10 patients with partial epilepsy, 10 patients with primary generalized epilepsy who were not currently prescribed anticonvulsant therapy, and 10 control subjects. Using an electromyography machine, stimulus intensity was performed to produce the target (40% of maximum) compound muscle action potentials and compound sensory action potentials. The currents required for different stimulus durations, 0.05, 0.1, 0.2, 0.3, 0.5, and 1 ms, were produced. Stimulus-response curves were then constructed, and the strength-duration time constants were estimated using Weiss's formula. Results: The rheobase of motor and sensory fibres was lower in the control group than the values of patients before and after CBZ and VPA therapy. Conclusions: In the PNS of epileptic patients, CBZ and VPA therapy results in decreased axonal excitability. This method may be used in investigating the underlying pathology of peripheral nerve diseases in vivo.
Health related quality of life in patients admitted for video-electroencephalography monitoring diagnosed with epilepsy or psychogenic non-epileptic seizures
(2016) Yerdelen, Deniz; Altintas, Ebru; 26818167
Objective: To determine the health related quality of life (HRQOL) in patients with epilepsy or psychogenic non-epileptic seizures (PNES). Methods: This cross-sectional study was carried out between December 2010 and December 2014 in the Department of Neurology and Psychiatry, Faculty of Medicine, Baskent University, Adana, Turkey. Patients who were admitted for video-electroencephalography monitoring and diagnosed of epileptic seizures or PNES were asked to complete a questionnaire from the World Health Organization Quality of Life, and psychiatric comorbidities were diagnosed using the structured clinical interview for Diagnostic and Statistical Manual of Mental Disorders Fourth Edition. Results: Patients with epilepsy and PNES were found to have similar HRQOL in physical, psychological, social, and environmental domains. However, the percentage of comorbid psychiatric disorders were higher in patients with PNES than patients with epilepsy. Conclusion: Patients with epilepsy and PNES have similar HRQOL, and PNES are resistant to the standard medical therapies used for the treatment of epileptic seizures. The direct lifetime cost of undiagnosed PNES may be of equal with intractable epilepsy. A better understanding of the impact of PNES manifestations and epilepsy would help to provide appropriate clinical, psychological and social care.
Tremor onset with acute frontal infarct and disappearance with the second stroke
(2015) Yerdelen, Deniz; Yetkinel, Selin; Dogan, Ali; 25864070
Ischemic stroke associated movement disorders can be seen as the first sign of a stroke or as a delayed onset development. Tremor after a stroke is a rare finding among movement disorders. In addition to reports of tremor caused by cerebral infarction of varied locations, data on the disappearance of existing tremor following infarction is also available. In this report, we present a case with acute tremor in the contralateral hand following frontal cortical infarction, and disappearance of the tremor after the second infarction comprising large areas in the same hemisphere.