Browsing by Author "Yasar, Sirin"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    A Controlled Study to Examine the Effect of Topical Sucralfate on Radiofrequency-induced Burn Wounds in Rats
    (2020) Yasar, Sirin; Yasar, Bulent; Yorusun, Asli; Gunes, Pembegul; Kayadibi, Huseyin; Ercin, Zuhal; Aytekin, Sema; 32294061
    Several preclinical studies have shown topical sucralfate facilitates wound repair. PURPOSE: This study aimed to evaluate the effect of 10% topical sucralfate on healing radiofrequency-induced burn wounds in rats. METHODS: Twenty (20) male rats were divided into 2 equal groups. Using radiofrequency, 4 full-thickness, 1 cm in diameter round burns were created on the backs of the rats that then were randomized to receive twice-daily treatment for 30 days with 10% sucralfate or neutral cream. Biopsies were taken on days 4, 7, 14, and 21 to analyze fibrin-leukocyte crut, edema density, epidermal-dermal cell infiltration, amount of fibroblast and collagen fibers, amount of elastic fibers, neovascularization-angiogenesis, and reepithelialization-granulation tissue. Data were collected to a spreadsheet and entered into statistical software for analysis. Histopathological features were classified as categorical variables and compared using the.2 test and Fisher's exact test. When chi(2) was used, Yates' correction for continuity was performed. All reported P values were 2-tailed; P less than .05 was considered statistically significant. RESULTS: On day 4, improvement in edema density (P=.034), epidermal detachment (P=.020), epidermal-dermal cell infiltration (P=.007), and polymorphonuclear leukocyte infiltration (P=.021) were statistically more significant in the sucralfate than control group. On day 7, epidermal-dermal cell infiltration (P=.007) and elastic fibers P=.050) were statistically more significant in the sucralfate group. On day 14, angiogenesis (P=.029), reepithelialization (P=.035), and granulation tissue (P=.003) were statistically more significant in the sucralfate group. By the end of the study (day 30), angiogenesis (P=.010), reepithelialization (P<.001), fibroblast density (P=.016), granulation tissue (P=.035), and collagen density (P=.002) were significantly improved in the sucralfate group versus the control group. CONCLUSION: In a rat wound model, 10% topical sucralfate was found to histopathologically facilitate the healing process compared to the control group. Controlled clinical studies are needed to elucidate the effect of this treatment in human wounds.
  • No Thumbnail Available
    Item
    Topical Sucralfate Cream Treatment for Aplasia Cutis Congenita with Dystrophic Epidermolysis Bullosa: A Case Study
    (2018) Yasar, Sirin; Yasar, Bulent; Cebeci, Filiz; Bayoglu, Duygu; Nuhoglu, Cagatay; 30398936
    Bart syndrome consists of aplasia cutis congenita (ACC) and dominant or recessive dystrophic epidermolysis bullosa (DEB), associated with skin fragility and nail dysplasia. ACC in DEB is thought to be caused by trauma, the most cited cause being in utero formation of bullae consequent to friction of the limbs. Epidermolysis bullosa (EB) refers to a hereditary mechanobullous disease following trauma, characterised by formation of blisters on the skin and mucous membranes. There are four categories of the disease, including epidermolysis bullosa simplex, junctional epidermolysis bullosa, dystrophic epidermolysis bullosa and Kindler syndrome. Infection, sepsis and death may occur as a consequence of generalised blistering with complication. We present the case of a newborn diagnosed with DEB and whose lesions became almost fully epithelialised after treatment with 10% topical sucralfate. Declaration of interest: The authors have no conflicts of interest to declare.