Browsing by Author "Yasar, Bulent"

Now showing 1 - 4 of 4

Adding stewed apricot juice to senna improves quality of colon cleansing in preparation for colonoscopy
(2017) Yasar, Bulent; Abut, Even; Kayadibi, Huseyin; Akdogan, Fatih; Gonen, Can
Background: To achieve optimal colonoscopic examination, the bowel must be sufficiently cleansed. However, none of the currently available colonoscopy preparation regimens is safe, efficient, and comfortable. The aim of this study was to determine whether adding stewed apricot juice to senna increased patient comfort and improved bowel cleansing during colonoscopy preparation. Methods: Outpatients of both genders who were over 18 years old and were referred for elective colonoscopy were randomly allocated to drink stewed apricot juice with senna or senna by itself. The quality of the colon cleansing was evaluated using the Ottawa scale. Patient tolerance and adverse events were evaluated through the completion of a questionnaire. Results: The study included a total of 128 patients in the randomization procedure. A significantly greater cleansing effect was observed using stewed apricot juice plus senna in the right and transverse colon (p = 0.038, p = 0.037 respectively). It was also determined that in the stewed apricot juice plus senna group, overall cleansing was superior (p < 0.001), total colonoscopy (17.6 min vs. 22.8 min, p = 0.048) and cecal intubation (7.4 min vs. 11.2 min, p = 0.042) times were shorter, and the colonoscopy procedure was easier (79.4% vs. 49.2%, p < 0.001). No differences were observed between the groups with respect to patient acceptance, compliance, and adverse events. In the stewed apricot juice plus senna group, 91.2% of patients stated their willingness to receive the same regimen in the future compared to 80% of the patients in the senna alone group (p = 0.037). Conclusion: The addition of natural, stewed apricot juice to senna significantly improves cleansing outcomes without additional adverse effects.
Behcet's Disease-Related Superior Vena Cava Syndrome and Bleeding Downhill Varices: A Rare Complication
(2017) Yasar, Bulent; Kilicioglu, Gamze; 28467587
Obstruction of the superior vena cava (SVC) due to any cause results in development of venous collaterals in the upper part of the esophagus, known as "downhill" varices. Although rare, bleeding can be life-threatening. Presently described is case of Behcet's disease-related SVC occlusion in a patient who presented with gastrointestinal bleeding from upper esophageal varices.
A Controlled Study to Examine the Effect of Topical Sucralfate on Radiofrequency-induced Burn Wounds in Rats
(2020) Yasar, Sirin; Yasar, Bulent; Yorusun, Asli; Gunes, Pembegul; Kayadibi, Huseyin; Ercin, Zuhal; Aytekin, Sema; 32294061
Several preclinical studies have shown topical sucralfate facilitates wound repair. PURPOSE: This study aimed to evaluate the effect of 10% topical sucralfate on healing radiofrequency-induced burn wounds in rats. METHODS: Twenty (20) male rats were divided into 2 equal groups. Using radiofrequency, 4 full-thickness, 1 cm in diameter round burns were created on the backs of the rats that then were randomized to receive twice-daily treatment for 30 days with 10% sucralfate or neutral cream. Biopsies were taken on days 4, 7, 14, and 21 to analyze fibrin-leukocyte crut, edema density, epidermal-dermal cell infiltration, amount of fibroblast and collagen fibers, amount of elastic fibers, neovascularization-angiogenesis, and reepithelialization-granulation tissue. Data were collected to a spreadsheet and entered into statistical software for analysis. Histopathological features were classified as categorical variables and compared using the.2 test and Fisher's exact test. When chi(2) was used, Yates' correction for continuity was performed. All reported P values were 2-tailed; P less than .05 was considered statistically significant. RESULTS: On day 4, improvement in edema density (P=.034), epidermal detachment (P=.020), epidermal-dermal cell infiltration (P=.007), and polymorphonuclear leukocyte infiltration (P=.021) were statistically more significant in the sucralfate than control group. On day 7, epidermal-dermal cell infiltration (P=.007) and elastic fibers P=.050) were statistically more significant in the sucralfate group. On day 14, angiogenesis (P=.029), reepithelialization (P=.035), and granulation tissue (P=.003) were statistically more significant in the sucralfate group. By the end of the study (day 30), angiogenesis (P=.010), reepithelialization (P<.001), fibroblast density (P=.016), granulation tissue (P=.035), and collagen density (P=.002) were significantly improved in the sucralfate group versus the control group. CONCLUSION: In a rat wound model, 10% topical sucralfate was found to histopathologically facilitate the healing process compared to the control group. Controlled clinical studies are needed to elucidate the effect of this treatment in human wounds.
Topical Sucralfate Cream Treatment for Aplasia Cutis Congenita with Dystrophic Epidermolysis Bullosa: A Case Study
(2018) Yasar, Sirin; Yasar, Bulent; Cebeci, Filiz; Bayoglu, Duygu; Nuhoglu, Cagatay; 30398936
Bart syndrome consists of aplasia cutis congenita (ACC) and dominant or recessive dystrophic epidermolysis bullosa (DEB), associated with skin fragility and nail dysplasia. ACC in DEB is thought to be caused by trauma, the most cited cause being in utero formation of bullae consequent to friction of the limbs. Epidermolysis bullosa (EB) refers to a hereditary mechanobullous disease following trauma, characterised by formation of blisters on the skin and mucous membranes. There are four categories of the disease, including epidermolysis bullosa simplex, junctional epidermolysis bullosa, dystrophic epidermolysis bullosa and Kindler syndrome. Infection, sepsis and death may occur as a consequence of generalised blistering with complication. We present the case of a newborn diagnosed with DEB and whose lesions became almost fully epithelialised after treatment with 10% topical sucralfate. Declaration of interest: The authors have no conflicts of interest to declare.