Browsing by Author "Vahidfar, Shahla"

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    Can Platelet-Rich Plasma Be As Effective As Corticosteroids in the Treatment of Frozen Shoulder in Rats? Experimental Animal Study
    (2023) Azarabadi, Javid Mohammadzadeh; Vahidfar, Shahla; Simsek, Ekin Kaya; Simsek, Duygu Turkbey; 0000-0003-2393-3535; JWO-8929-2024
    Aim: Frozen shoulder is an important health problem that causes significant socio-economic losses as it affects daily life. Its etiopathogenesis has not been fully elucidated. A long recovery period leads to new searches for treatment. In the treatment of frozen shoulder, corticosteroids (CS) and platelet-rich plasma (PRP) are applied, among other options. The aim of this study is to compare the effectiveness of CS and PRP in frozen shoulder. Material and Methods: A secondary frozen shoulder model was created in rats. At the end of the eight-week waiting period, the shoulder joint was released. The rats, divided into three groups, were injected intraarticularly with saline in the first group, CS in the second group, and PRP in the third group. After a two-week waiting period, the shoulder joint range of motion of the sacrificed rats was measured. The joint capsule was evaluated histologically for synovial inflammation, type 3 collagen, capillary proliferation, subscapular bursa adhesion and fibrosis. Result: CS and PRP application did not affect the range of motion of the joint. A significant increase in synovial inflammation a decrease in fibrosis, type 3 collagen deposition, subscapular bursa adhesion were revealed. It was observed that vascular proliferation did not change. Discussion: CS and PRP treatment yielded similar results in the frozen shoulder animal model. While both of these treatments do not affect the range of motion of the joint, they reverse the pathological changes in a frozen shoulder.
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    Ultrasonographic Evaluation of Achilles Tendon in Early Axial Spondyloarthropathy: Is There Any Difference between Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthropathy?
    (2018) Vahidfar, Shahla; Sunar, Ismihan; Ataman, Sebnem; Yilmaz, Gurkan; Azarabadi, Javid M.; Bolukbasi, Ayse; 0000-0002-4435-5677; 0000-0003-3570-3825; AAB-7763-2019; AAA-2977-2020
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    Ultrasonographic evaluation of Achilles tendon: Is there any difference between ankylosing spondylitis, non-radiographic axial spondyloarthropathy and controls?
    (2020) Vahidfar, Shahla; Sunar, Ismihan; Ataman, Sebnem; Yilmaz, Gurkan; Azarabadi, Javid M.; Bolukbasi, Ayse; 31985181
    Purpose: The aim is to evaluate Achilles tendon enthesopathy with ultrasound (US) in ankylosing spondylitis (AS) and non-radiographic axial SpA (nr-axSpA) patients and controls, and compare these groups in terms of associations between disease activity parameters and ultrasonographic Achilles enthesitis signs. Methods: A total of 24 AS and 20 nr-axSpA patients fulfilling the Assessment in Spondyloarthritis International Working Group criteria for axSpA and 30 controls were enrolled. Demographic characteristics, erythrocyte sedimentation rate, C-reactive protein (CRP), human leukocyte antigen (HLA)-B27, Bath AS Disease Activity Index, Bath AS Functional Index, Bath AS Metrology Index, Maastricht AS Enthesitis Score (MASES), AS Disease Activity Score-CRP, modified Stoke AS Spine Score (m-SASSS) scores and ultrasonographic findings were noted. Results: HLA-B27 positivity, extra-articular and peripheral involvement, disease activity, functional status, mean m-SASSS, ultrasonographic gray scale (GS) and total scores were similar between AS and nr-axSpA groups. In GS, tendon echotexture scores were significantly different across all groups (0.812 +/- 0.384 in AS, 0.575 +/- 0.466 in nr-axSpA, 0.017 +/- 0.091 in controls; P < .001). Entheseal calcification scores were similar in AS and nr-axSpA patients, and higher than controls (P = .001). Bone profile scores were similar in patients with AS and nr-axSpA, and higher than controls (P = .010). When the correlations between US findings and disease activity and functional status were considered, power Doppler US (PDUS) and MASES total scores were positively correlated in the AS group (P = .045; r = .41). Conclusion: AS and nr-axSpA patients were found to be similar in various clinical, functional, and US findings indicating that these 2 entities are different phenotypic reflections of the same disease spectrum. The positive correlation between PDUS and MASES scores in AS patients substantiate the performance of MASES in evaluation of entheseal activity.