Browsing by Author "Uysal, Fatmanur"

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    Effect Of Tacrolimus In The Inner Ear Of Rats
    (2022) Uysal, Fatmanur; Erbek, Selim S.; Erbek, Seyra; Culhaoglu, Belde
    Purpose: Tacrolimus, an immunosuppressive agent, is used especially after organ transplantation. It has been asserted that tacrolimus has protective effects on the auditory system in some studies while it has negative effects in other studies. The purpose of our study is to investigate the effect of tacrolimus on the inner ear of the rats. Materials and Methods: 20 healthy Sprague Downey male rats weighing 250-350 grams were included in our study. The first group of rats were given 1mg/kg tacrolimus (n:7), the second group of rats were given 0.1 mg/kg tacrolimus (n:7), and the third group (n:6) was the non-administered control group. The first measurements of all rats were taken with distortion-product otoacoustic emission before starting the experiment. Then, tacrolimus drug was administered by gavage method to the 1st and 2nd groups along 30 days. The last measurement was repeated on the 30th day. Results: According to the results of the first measurements, emission was obtained in all rats and the responses were found to have similar characteristics. Similarly, the difference between the signal noise rate values in the last measurements taken from the groups not show any statistical significance. Conclusions: Based on the distortion-product otoacoustic emission measurements, it can be said that Tacrolimus does not have ototoxic effects on the auditory system of rats considering the administered dosage and time.
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    Multiple sklerozun alt tiplerine göre odyo-vestibüler bulgular
    (Başkent Üniversitesi Sağlık Bİlimleri Enstitüsü, 2022) Uysal, Fatmanur; Köycü, Alper
    Multiple skleroz (MS) genellikle birkaç günden birkaç aya kadar süren ataklarla seyreden, merkezi sinir sisteminin (MSS) kronik otoimmün demiyelinizan ve aynı zamanda nörodejeneratif bir hastalığıdır. Birçok sistemi etkilediği gibi işitme ve denge sistemi üzerine de etkileri vardır. Çalışmanın amacı MS’in alt tiplerine göre odyo-vestibüler bulguların objektif ve subjektif olarak değerlendirilmesidir. Çalışmaya 18 yaş ve üzeri erişkin hastalar dâhil edilmiştir. Katılımcılar, klinik izole sendrom (KİS), relapsing remitting MS(RRMS), sekonder progresif MS (SPMS), primer progresif MS (PPMS) ve kontrol grubu olmak üzere gruplandırılmıştır. Araştırma toplam 50 bireyden oluşmaktadır. Her bir katılımcıya immitansmetrik inceleme yapıldıktan sonra yüksek frekansların da dahil olduğu saf ses odyometri testi, okülomotor testler (gaze fiksasyon testi, sakkadik test, pursuit testi, optokinetik test), VNG (videonistagmografi) ile pozisyonel testler ve baş savurma testi (VHIT) uygulanmıştır. Aynı zamanda baş dönmesinin subjektif değerlendirmesi olarak Dizziness Handikap Envanteri (DHE) de yapılmıştır. Araştırmamızda SPMS alt tipinin işitme eşikleri diğer MS alt tiplerinin işitme eşiklerine göre istatistiksel olarak anlamlı derecede daha düşük bulunmuştur (p˂0,005). PPMS alt tipinde yer alan hastaların okülomotor testlerdeki patoloji varlığı diğer MS alt tiplerindeki patoloji varlığına göre istatistiksel olarak anlamlı derecede daha fazla bulunmuştur (p˂0,005). Çalışmamızda hiçbir MS alt tipinde ve kontrol grubunda spontan nistagmus ve baş sallama testinden sonra nistagmus gözlenmemiştir. Katılımcılarda VNG test bataryasında değerlendirilen pozisyonel testler ile sağ ve sol vHIT kanal kazançlarında da istatitistiksel olarak farklılık gözlenmemiştir (p>0,005). Çalışmamızda DHE skorları ile MS alt tipleri arasında istatistiksel olarak anlamlı farklılık bulunmuştur (p˂0,005). DHE skorları medyan değerine göre PPMS ve SPMS alt tiplerinin daha yüksek skorlamalar yaptığı belirlenmiştir. Böylece daha ağır seyreden MS alt tiplerinin subjektif bulgusunun da daha fazla olduğu çıkarımında bulunulmuştur. Çalışmamız sonucunda MS’in işitme ve denge sistemi üzerinde etkilerinin olduğu görülmektedir. MS hastalığının sistemler üzerine etkileri ne kadar fazla olur ise prognozun da aynı derecede kötü olabileceğini düşünmekteyiz. Multiple sclerosis (MS) is a chronic autoimmune demyelinating and neurodegenerative disease of the central nervous system (CNS), which usually progresses with attacks lasting from a few days to a few months. As it affects many systems, it also has effects on the hearing and balance system. The aim of the study is to evaluate the audio-vestibular findings objectively and subjectively according to the subtypes of MS. Adult patients aged 18 years and older were included in the study. Participants were grouped into clinical isolated syndrome (CIS), relapsing remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS), and control group. The research consists of 50 individuals in total. Pure tone audiometry test including high frequencies, oculomotor tests (gaze fixation test, saccadic test, pursuit test, optokinetic test), VNG (videonystagmography) positional tests and video head impulse test (VHIT) were applied to each participant after immitansmetric examination was performed. The Dizziness Handicap Inventory (DHE) was also performed as a subjective assessment of dizziness. In our study, the hearing thresholds of the SPMS subtype were found to be statistically significantly lower than the hearing thresholds of the other MS subtypes (p˂0.005). The presence of pathology in the oculomotor tests of the patients in the PPMS subtype was found to be statistically significantly higher than the presence of pathology in the other MS subtypes (p˂0.005). Spontaneous nystagmus and nystagmus after the nod test were not observed in any MS subtype and control group in our study. There was no statistical difference between the positional tests evaluated in the VNG test battery and the right and left vHIT channel gains in the participants (p>0.005). In our study, a statistically significant difference was found between DHE scores and MS subtypes (p˂0.005). It was determined that PPMS and SPMS subtypes scored higher than the median value of DHE scores. Thus, it was concluded that more severe MS subtypes had more subjective findings.As a result of our study, it is seen that MS has effects on the hearing and balance system. We think that the more the effects of MS disease on the systems, the worse the prognosis.