Browsing by Author "Uner, Aylin"

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Frequency of headache among university students and its effect on daily living activities
(2021) Ocal, Ruhsen; Iyigundogdu, Ilkin; Kirnap, Nazli Gursoy; Talu, Irem; Alkislar, Defne; Aras, Dilay; Uner, Aylin; Uzunalioglu, Ece; 0000-0001-7860-040X; AAJ-2053-2021
Background & Objective: Headache is a common symptom in the general population. The aim of this study was to investigate the frequency of headache among a university students population in Ankara, Turkey; and to evaluate the factors affecting the headache and the effect of headache on students' quality of life. Methods: A face-to-face questionnaire was applied to all participants in the study. In the questionnaire, demographic data, personal background and family history of the participants as well as the presence of headache were collected. The characteristic features of the headache, accompanying symptoms and medication use for the headache were evaluated. The 36-Item Short Form Survey (SF-36), Beck depression and Beck anxiety scales were administered to all participants. Results: Three hundred and sixty six university students participated in the study. Three hundred and thirty one participants (90.4%) had experienced headache at least once in their lifetime. Headache was more common in women (p 0.01). Depression was found in 135 (36.9%) students with the Beck depression scale, and anxiety was found in 236 (64.5%) students with the Beck anxiety scale. There was no relationship between depression or anxiety and the presence of headache (p 0.05). Emotional role difficulties, social function, pain and general health scores were significantly lower on SF-36 in the group with headache (p<0.05) than without headache. Conclusion: Headache adversely affects the quality of life and is a common symptom among university students, independent of depression and anxiety.
Optogenetic Spreading Depression Elicits Trigeminal Pain and Anxiety Behavior
(2020) Harriott, Andrea M.; Chung, David Y.; Uner, Aylin; Bozdayi, Refik O.; Morais, Andreia; Takizawa, Tsubasa; Qin, Tao; Ayata, Cenk; 33016466
Objective Cortical spreading depression (SD) is an intense depolarization underlying migraine aura. Despite the weight of evidence linking SD to the pain phase of migraine, controversy remains over a causal role of SD in cephalgia because of the invasive nature of previous SD induction methods. To overcome this problem, we used a novel minimally invasive optogenetic SD induction method and examined the effect of SD on behavior. Methods Optogenetic SD was induced as a single event or repeatedly every other day for 2 weeks. End points, including periorbital and hindpaw mechanical allodynia, mouse grimace, anxiety, and working memory, were examined in male and female mice. Results A single SD produced bilateral periorbital mechanical allodynia that developed within 1 hour and resolved within 2 days. Sumatriptan prevented periorbital allodynia when administered immediately after SD. Repeated SDs also produced bilateral periorbital allodynia that lasted 4 days and resolved within 2 weeks after the last SD. In contrast, the hindpaw withdrawal thresholds did not change after repeated SDs suggesting that SD-induced allodynia was limited to the trigeminal region. Moreover, repeated SDs increased mouse grimace scores 2 days after the last SD, whereas a single SD did not. Repeated SDs also increased thigmotaxis scores as a measure of anxiety. In contrast, neither single nor repeated SDs affected visuospatial working memory. We did not detect sexual dimorphism in any end point. Interpretation Altogether, these data show a clinically congruent causal relationship among SD, trigeminal pain, and anxiety behavior, possibly reflecting SD modulation of hypothalamic, thalamic, and limbic mechanisms. ANN NEUROL 2020
Recurrent Episodic Cortical Spreading Depressions Produce Trigeminal Mechanical Allodynia and Anxiety-Related Behaviors
(2020) Chung, David Y.; Uner, Aylin; Morais, Andreia; Takizawa, Tsubasa; Qin, Tao; Ayata, Cenk; Harriott, Andrea M