Browsing by Author "Turk, Hatice Evren Eker"

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    Sugammadex Given for Rocuronium-Induced Neuromuscular Blockade in Infants: A Retrospective Study
    (2016) Ozmete, Ozlem; Bali, Cagla; Cok, Oya Yalcin; Turk, Hatice Evren Eker; Ozyilkan, Nesrin Bozdogan; Civi, Soner; Aribogan, Anis; 0000-0002-1055-5152; 0000-0003-3004-2626; 0000-0002-7901-0185; 0000-0002-4973-8132; 0000-0003-2615-1918; 0000-0002-4419-5693; 0000-0001-5845-699X; 27871583; AAI-7779-2021; U-2400-2018; AAI-7998-2021; AAI-8790-2021; AAI-8769-2021; S-8336-2019; AAI-7880-2021
    Study Objective: To evaluate the efficacy and safety of sugammadex in reversing profound neuromuscular block induced by rocuronium in infant patients. Design: Retrospective observational study. Setting: University teaching hospital. Patients: Twenty-six infants (2-12 months of age; 3-11 kg) with an American Society of Anesthesiologists classification I, II, or III who were scheduled to undergo neurosurgical procedures were included in the study. Interventions: Anesthesia was induced with 5 mg/kg thiopental, 1 mu g/kg fentanyl and 0.6 mg/kg rocuronium. Sevoflurane was administered to all patients after intubation. Methods: The neuromuscular block was monitored with acceleromyography using train-of-four (TOF) stimuli. Patients received additional doses of rocuronium to maintain a deep block during surgery. If profound neuromuscular block (TOF, 0) persisted at the end of the surgery, 3 mg/kg sugammadex was administered. Measurements: The demographic data, surgeries, and anesthetic agents were recorded. The time from sugammadex administration to recovery of neuromuscular function (TOF ratio, >0.9) and complications during and after extubation were also recorded. Main results: Twenty-six infants who had a deep neuromuscular block (TOF, 0) at the end of surgery received 3 mg/kg sugammadex. The mean recovery time of the T4/T1 ratio of 0.9 was 112 seconds. No clinical evidence of recurarization or residual curarization was observed. Conclusions: The efficacy and safety of sugammadex were confirmed in infant surgical patients for reversal of deep neuromuscular block induced by rocuronium. (C) 2016 Elsevier Inc. All rights reserved.