Browsing by Author "Toledo, Alexander H."

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    Inflammatory Mediators of Liver Ischemia-Reperfusion Injury
    (Başkent Üniversitesi, 2009-06) Walsh, Kyle B.; Toledo-Pereyra, Luis H.; Lopez-Neblina, Fernando; Rivera-Chavez, Fernando A.; Toledo, Alexander H.
    Liver ischemia and reperfusion — which cause liver damage that is significant in a variety of diseases, injuries, and procedures (including but not limited to trauma and transplant) — have been the focus of many investigations in recent years. Although the mechanisms of ischemia-reperfusion injury are numerous and complex, many advances in treatment have been made. The following review considers recent advances in the understanding of hepatic ischemia-reperfusion injury and focuses on inflammatory mediators of significance. To provide a unique analysis and evaluation, we emphasized the most recent pertinent investigations of the last decade. Specific topics addressed include reactive oxygen species, nitric oxide, toll-like receptors, ischemic preconditioning, T cells, heme oxygenase-1, heat shock proteins, erythropoietin, selectins, protein kinases, matrix metalloproteinases, and cytokines.