Browsing by Author "Tokgoz, Husnu"

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    Efficacy of Silodosin in the Treatment of Distal Ureteral Stones 4 to 10 Mm in Diameter
    (2015) Yuksel, Mustafa; Yilmaz, Serdar; Tokgoz, Husnu; Yalcinkaya, Soner; Bas, Serkan; Ipekci, Tumay; Yildiz, Ali; Ates, Nihat; Savas, Murat; 0000-0002-3068-4699; 0000-0002-2755-0526; 0000-0003-0293-9989; 26770537; AAD-5570-2019; AAB-2986-2020; GWC-8116-2022
    Purpose: Few studies have investigated the efficacy of silodosin, a recently introduced selective alpha 1-A adrenoceptor antagonist, in medical expulsive therapy (MET) for ureteral calculi. The results of these studies, which all evaluated the efficacy of 8 mg/day, indicate that silodosin is a potential treatment for ureteral calculi. This study investigated the efficacy of 4 mg/day of silodosin for MET of distal ureteral stones 4 to 10 mm in diameter. Material and Method: After 70 patients had been randomized into 2 groups of 35 patients each, both the control and experimental groups (groups 1 and 2, respectively) were advised to take 75 mg/day of diclofenacsodiumas needed for pain relief but only the experimental group to take 4 mg/day of silodosin. After 21 days, the groups were compared regarding the stone expulsion rate and duration, number of renalcolicepisodes, and analgesicdosage. Results: The median expulsion rates were 71.4% and 91.4% in groups 1 and 2, respectively, and the difference between them was significant (P= 0.031). The median expulsion durations were 12.91 +/- 6.14 and 8.03 +/- 4.99 days, respectively, and the difference between them was significant (P< 0.001). No significant differences were found regarding the median number of renal colic episodes or median analgesic dosage. While no patients in group 1 experienced side effects, 5 patients (14%) in group 2 experienced retrograde ejaculation. Conclusion: These results indicate that 4 mg/day of silodos in facilitates the expulsion of distal ureteral stones 4 to 10 mm in diameter but does not significantly reduce the number of renal colic episodes or analgesic dosage.