Browsing by Author "Tiftikcioglu, Bedile Irem"

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Comparison of conventional and modern methods in determining ischemic stroke etiology by general and stroke neurologists
(2019) Kunt, Refik; Kutluk, Mustafa Kursad; Tiftikcioglu, Bedile Irem; Afsar, Nazire; Erdemoglu, Ali Kemal; Gedizlioglu, Muhtesem; Ozturk, Vesile; 0000-0002-4573-3844; 30764594; I-7963-2019
Background/aim: This study aimed to investigate the consistency between stroke and general neurologists in subtype assignment using the Trial of ORG-10172 in Acute Stroke Treatment (TOAST) and Causative Classification of Stroke (CCS) systems. Materials and methods: Fifty consecutive acute ischemic stroke patients admitted to the stroke unit were recruited. Patients were classified by two stroke and two general neurologists, each from different medical centers, according to TOAST followed by the CCS. Each neurologist was assessed for consistency and compliance in pairs. Concordance among all four neurologists was investigated and evaluated using the kappa (kappa) value. Results: The kappa (kappa) value of diagnostic compliance between stroke neurologists was 0.61 (95% CI: 0.45-0.77) for TOAST and 0.78 (95% CI: 0.62-0.94) for CSS-5. The kappa (kappa) value was 0.64 (95% CI: 0.48-0.80) for TOAST and 0.75 (95% CI: 0.60-0.91) for CCS-5 for general neurologists. Compliance was moderate [kappa: 0.59 (95% CI: 0.52-0.65)] for TOAST and was strong [kappa: 0.75 (95% CI: 0.68-0.81)] for CCS-5 for all 4 neurologists. 'Cardioembolism' (91.04%) had the highest compliance in both systems. The frequency of the group with 'undetermined etiologies' was less in the CCS (26%) compared to TOAST. Conclusion: The CCS system improved compliance in both stroke and general neurologists compared with TOAST. This suggests that the automatic, evidence-based, easily reproducible CCS system was superior to the TOAST system.
Optical Coherence Tomography Angiography (OCTA) In Differential Diagnosis Of Aquaporin-4 Antibody Seronegative NMOSD And Multiple Sclerosis
(2022) Tiftikcioglu, Bedile Irem; Emre, Sinan; Idiman, Fethi; Idiman, Egemen; 35030370
Backround: Optic neuritis(ON) is a common feature of both relapsing-remitting multiple sclerosis(RRMS) and neuromyelitis optica spectrum disorders(NMOSD). It is crucial to early differentiate these two diseases, as they differ in pathophysiology and treatment.& nbsp;Objective: To compare NMOSD and RRMS patients using optical coherence tomography(OCT) and OCT angiography(OCTA) to assess retinal microvascular network differences.& nbsp;Methods: Fourteen RRMS (28 eyes) and 9 NMOSD patients(18 eyes), and 11 controls were enrolled. Seropositivity for aquaporin-4 antibody (anti-AQP4 Abs) was 44.4%. Peripapillary and macular retinal nerve fiber layer (RNFL) thickness, superficial peripapillary and macular vessel density(VD), area, perimeter and circularity of foveal avascular zone(FAZ) were analyzed.& nbsp;Results: OCTA showed reduction in peripapillary and macular VD and FAZ size in NMOSD+ON compared to RRMS+ON and controls (p = 0.001, p < 0.001 and p = 0.010, p < 0.001 respectively). Peripapillary VD was similar in RRMS +ON and controls. Peripapillary VD in monophasic seronegative NMOSD+ON eyes was significantly lower than monophasic RRMS+ON eyes (p = 0.030), which was no different from controls. FAZ area was smaller in unaffected eyes in NMOSD than RRMS and controls.& nbsp;Conclusions: Both OCT and OCTA revealed considerable differences between RRMS and NMOSD patients, providing promising results in favor of clinical utility of OCTA in differential diagnosis of ON, particularly in antiAQP4 antibody negative patients. OCTA might be a useful biomarker in differentiating NMOSD from MS.
Relationship of Scoliosis with Pain and Respiratory Dysfunction in Patients with Duchenne Muscular Dystrophy
(2020) Sertpoyraz, Filiz Meryem; Tiftikcioglu, Bedile Irem; Baydan, Figen; Tuncay, Bakiye; Gunduz, Nihan Erdinc; Dikici, Aylin; Zorlu, Yasar; 0000-0002-4573-3844; I-7963-2019
Introduction Scoliosis is one of the major causes of respiratory dysfunction in patients with Duchene muscular dystrophy (DMD). Also, progressive spinal deformity severely affects walking and sitting, and can also lead to pain and difficulty in patient care. Although the relationship between scoliosis and respiratory functions was extensively studied, its impact on pain has not been examined. Hereby, we aimed to evaluate the relationship between scoliosis and respiratory dysfunction and pain, together with the frequency of scoliosis in Turkish DMD patients. Materials and Methods The demographical data, rate, and region of scoliosis, pain, and respiratory functions were evaluated in 69 male DMD patients. The severity of pain was evaluated with a visual analog scale (VAS) and the degree of scoliosis was assessed with Cobb angle. Forced vital capacity was used to grade the pulmonary functions. Results Scoliosis was present in 52.2% of the patients, mainly in the dorsolumbar region. Pain was present in 53.6% of the patients, most commonly in the back and lumbar regions. The rate of pulmonary dysfunction was 49.3%. Of the 36 patients with scoliosis, prevalences of pain and respiratory dysfunction were 77.7 and 50.0%, respectively. Scoliosis was significantly associated with pain and respiratory dysfunction, as expected. Conclusion The prevalence of pain and respiratory dysfunction is considerably high in DMD patients with scoliosis. These patients should be closely monitored for pain and deterioration in respiratory functions, to ease their daily care, increase their quality of life, and preserve the functionality, as long as possible.
Vaccination in Individuals with Multiple Sclerosis - Part I
(2023) Cinar, Bilge Piri; Tuncer, Asli; Bilge, Nuray; Bunul, Sena Destan; Gozubatik Celik, Rabia Gokcen; Ciftci, Eda Derle; Genc, Gencer; Karaman, Bedriye; Kilic, Ahmet Kasim; Sariteke, Alp; Seferoglu, Meral; Tiftikcioglu, Bedile Irem; Tunc, Abdulkadir; Uncu, Gulgun; Yavas, Irfan; Yetkin, Mehmet Fatih; Efendi, Husnu; Siva, Aksel; 0000-0001-6900-4702
Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system. It is a chronic disease, and in the evaluation of all other health and vital processes, decisions should be made by considering the disease process and the drugs used by the patient. Since vaccination can be performed at every stage of life, from childhood to adulthood, immune system activity, except where it is characteristic of the vaccine, should be reviewed in patients with MS. In this review, the applications of different vaccines in individuals with MS are discussed in two separate sections.