Browsing by Author "Tekindal, M. A."

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The Comparison of Neonatal Morbidities in Twin and Singleton Late Preterm Infants
(2016) Ince, D. Anuk; Turan, O.; Cigri, E.; Tekindal, M. A.; Yanik, F.; Ecevit, A.; 0000-0002-4369-2110; 0000-0002-7707-1881; 0000-0002-4060-7048; 0000-0002-2232-8117; I-6746-2016; AAJ-2333-2021; U-9270-2018; AAJ-4616-2021
Effects of Alendronate and Pamidronate on Apoptosis and Cell Proliferation in Cultured Primary Human Gingival Fibroblasts
(2015) Soydan, S. S.; Araz, K.; Senel, F. V.; Yurtcu, E.; Helvacioglu, F.; Dagdeviren, A.; Tekindal, M. A.; Sahin, F.; 0000-0002-6026-0045; 0000-0001-8990-8282; 0000-0001-7308-9673; 0000-0003-4930-8164; 0000-0002-4060-7048; 0000-0002-4475-0861; 25636638; AAH-8887-2021; P-2877-2014; AAC-7232-2020; AAA-2998-2021; AES-7155-2022; U-9270-2018
Data arising from the recent literature directed the researchers to study on the degree and extent of bisphosphonate toxicity on oral mucosa in further detail. The aim of this study is to determine the half maximal inhibitory concentration of pamidronate (PAM) and alendronate (ALN) on human gingival fibroblasts in vitro using 3-[4.5-thiazol-2-yl]-2.5-diphenyltetrazolium bromide (MTT) assay and to evaluate the effects of both agents on the proliferation and apoptotic indices. Cells used in the study were generated from human gingival specimens and divided into alendronate (n = 240), PAM (n = 240), and control groups (n = 60). Based on the MTT assay results, 10(-4), 10(-5), 10(-6), and 10(-7) M concentrations of both drugs were administered and the effects were evaluated for 6, 12, 24, 48, or 72 h periods. An indirect immunofluorescence technique was used to evaluate apoptotic (anti-caspase 3) and proliferation (anti-Ki67) indices. Toxicity of both PAM and ALN was found to be the most potent at 10(-4)-10(-5) M range. The apoptotic index of PAM group was found to be significantly higher than ALN group for all concentrations especially at 24 h incubation time (p < 0.05). The decrease in the proliferation index was found similar in first 48 h for both drugs; however, after 72 h of incubation decrease in proliferation index in PAM group was found to be significantly higher (p < 0.05). Micromolar concentrations of not only PAM but also ALN rapidly affect cells generated from human oral gingival tissue by inducing apoptosis together with inhibition of proliferation. Cytotoxic effects of both ALN and PAM on primary human gingival fibroblasts, which cause significant changes in apoptotic and proliferative indices as shown in this in vitro study, suggests that the defective epithelialization of oral mucosa is possibly a major factor on the onset of bisphosphonate-related osteonecrosis of the jaw cases.
Impact of Weight Loss on Epicardial Fat and Carotid Intima Media Thickness After Laparoscopic Sleeve Gastrectomy: A Prospective Study
(2018) Altin, C.; Erol, V; Aydin, E.; Yilmaz, M.; Tekindal, M. A.; Sade, L. E.; Gulay, H; Muderrisoglu, H.; https://orcid.org/0000-0002-3996-5681; https://orcid.org/0000-0003-3737-8595; https://orcid.org/0000-0002-0442-6178; https://orcid.org/0000-0003-0907-3647; https://orcid.org/0000-0002-9635-6313; https://orcid.org/0000-0002-2557-9579; 29571589; HGC-1839-2022; S-6973-2016; AAG-8233-2020; AAI-8276-2021; AAJ-6407-2021; AAQ-7583-2021
Background and aims: Cardiovascular disease (CVD) is one of the leading causes of mortality in obese patients. We aimed to investigate the influence of significant weight loss following laparoscopic sleeve gastrectomy (LSG) on carotid intima media thickness (CIMT) and epicardial fat thickness (EFT) which are the independent predictors of subclinical atherosclerosis. Methods and results: Patients were recruited for standard indications. A total of 105 patients (79 women and 26 men) with the mean age of 43.61 +/- 12.42 were prospectively enrolled. On Bmode duplex ultrasound; the mean CIMT at the far wall of both left and right common carotid arteries were measured. EFT was measured on the free wall of the right ventricle at enddiastole from the parasternal long-axis view by standard transthorasic 2D echocardiography. Delta (Delta) values were obtained by subtracting sixth month values from the baseline values. Body mass index (BMI) was significantly reduced from 46.95 +/- 7.54 to 33.54 +/- 6.41 kg/m2 (p < 0.001) in sixth months after LSG. Both EFT and CIMT were significantly decreased after surgery (8.68 +/- 1.95 mm vs. 7.41 +/- 1.87 mm; p < 0.001 and 0.74 +/- 0.13 mm vs. 0.67 +/- 0.11 mm; p < 0.001 respectively). A significant correlation between Delta EFT and Delta MI (r = 0.431, p < 0.001) was shown. Delta CIMT is significantly correlated with Delta EFT, Delta BMI and Delta systolic blood pressure (r = 0.310, r = 0.285 and r = 0.231 respectively, p < 0.05 for all). In multivariate stepwise linear regression analysis; among variables only Delta BMI was the independent predictor of Delta EFT (beta = 153, p = 0.001). Conclusion: Early atherosclerotic structural changes may be reversed or improved by sustained weight loss after LSG in asymptomatic obese patients. (C) 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Laser Acupuncture Prior to Heel Lancing for Pain Management in Healthy Term Newborns
(2016) Abbasoglu, A.; Cabioglu, T.; Tugcu, A. U.; Tekindal, M. A.; Tarcan, A.; 0000-0002-4060-7048; ABI-2113-2020; U-9270-2018
Serum Angiopoietin-1, Angiopoietin-2 and Periostin Levels in Children with Recurrent Bronchiolitis
(2018) Koksal, B. T.; Aydin, Ozdemir B.; Tekindal, M. A.; Ozbek, Yilmaz O.; https://orcid.org/0000-0001-9580-7656; AAF-2109-2021
Vascular endothelial growth factor and interleukin-33 levels in children with recurrent wheeze
(2019) Aydin, B.; Koksal, B.; Tekindal, M. A.; Ozbek, Yilmaz O.