Browsing by Author "Sonmez, E."

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Does Leptin Have A Role in The Development of Intracranial Meningiomas?
(2019) Sahinturk, F.; Sonmez, E.; Borcek, P.; Altinors, N.; https://orcid.org/0000-0002-0471-3177; https://orcid.org/0000-0002-5693-3542; AAI-7972-2021; AAI-8820-2021
Introduction: Meningiomas are the most frequent benign tumours of the intracranial cavity accounting for around 30% of all intracranial tumours. The majority of meningiomas are actually benign while a certain subset demonstrate a higher incidence of recurrence and unfavourable morbidity and mortality rates. Leptin, the product of the obese (ob) gene, is a 16-kDA polypeptide which is located on human chromosome 7. It plays a crucial role in the regulation of body weight by controlling food intake, energy metabolism and neuroendocrine function. Aim: To search for a possible relationship between leptin and intracranial meningioma formation. A prospective control clinical study was used. Patients and methods: According to WHO classification of CNS tumours, 20 patients with grade I and 12 patients harbouring grade II meningiomas were included in the study. Fasting blood glucose, blood insulin and leptin levels were determined. Leptin staining scores were evaluated immunohistochemically from the parafin blocks of the meningioma patients. Body mass index values and antidiabetic drug treatment were also noted. Results: No statistically significant relationship was noted between the grade I and grade II meningioma groups in all the parameters searched (body mass index, blood glucose levels, blood leptin levels, leptin staining score). The use of antidiabetic drug treatment was homogenous between the groups. Conclusion: The present study did not provide any evidence about a possible association between leptin and intracranial meningioma formation. However, research with a larger volume of patient groups, including grade III meningiomas is needed in order to substantiate such a relationship.
The effects of tacrolimus on cognitive functions in a rat model of cerebral vasospasm
(2021) Sahinturk, F.; Sonmez, E.; Altinors, N.; 0000-0002-0471-3177; AAI-7972-2021
Aim: The present study aims to demonstrate the efficacy of tacrolimus (TAC), an agent showing immunosuppressive effects through calcineurin inhibition, in the treatment of subarachnoid haemorrhage (SAH)-induced cerebral vasospasm in rat models. Material and Methods: The study, after gaining the approval of the ethics committee, included 18 male Sprague-Dawley rats which were allowed to swim in four directions within a Morris water maze until the cognitive function curves reached a plateau (4 days). After the retention swimming, four extremities were found while the rats were held in a prone position with the head at 20 degrees flexion under general anaesthesia. SAH was induced through the administration of 0.4 cc/ kg of autologous arterial blood into the cisterna magna. Tacrolimus (0.5 mg/ kg, 2 doses) was administered intraperitoneally for the treatment of the induced vasospasm, and its effi cacy was investigated. Conclusion: When the threeday all-direction swimming times of the control, of SAH and SAH-TAC groups were compared, a decrease was noted in the mean times of swimming within the group administered with tacrolimus after SAH, although a Kruskal-Wallis variance analysis did not indicate any significant difference in the distribution of the mean three-day swimming times between control, SAH and SAH-TAC groups, at a 95% confidence interval (P = 0.366).
In vitro and in vivo bacterial antifouling properties of phosphite plasma-Treated silicone
(2018) Akdogan, E.; Demirbilek, M.; Sen, Y.; Onur, M.A.; Azap, O.K.; Sonmez, E.; Sirin, H.T.; Mutlu, M.; 0000-0002-3171-8926; 0000-0002-5693-3542; AAK-4089-2021; AAI-8820-2021
In order to improve their bacterial antifouling property, silicone surfaces were functionalized through the plasma polymerization (PP) technique using diethyl phosphite as the precursor. The functionalized surfaces were characterized using contact angle measurements, contact angle titration, Fourier transform infrared-Attenuated total reflection spectroscopy and in vitro cytotoxicity assay. The amount of non-specific protein adsorption and the conformational changes of surface-Adsorbed proteins were investigated. Antifouling properties of the surfaces were evaluated in vitro and in vivo. PP functionalization generated a hydrophilic and amphoteric surface with a very good protein and bacterial antifouling property and caused less conformational changes on the secondary structure of surface-Adsorbed proteins. In in vivo conditions, no slime layer was formed around bacteria that adhered on the PP-functionalized surface. It is concluded that the amphoteric nature of the PP-functionalized surface is the reason for the good antifouling property. © 2019 ICE Publishing: All rights reserved.
Spontaneous vaginal extrusion of the distal catheter of a ventriculoperitoneal shunt
(2020) Sahinturk, F.; Sonmez, E.; Altinors, N.; 0000-0002-0471-3177; 0000-0002-5693-3542; AAI-7972-2021; AAI-8820-2021