Browsing by Author "Savaser, Ayhan"

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    In vitro and in vivo evaluation of linezolid loaded electrospun PLGA and PLGA/PCL fiber mats for prophylaxis and treatment of MRSA induced prosthetic infections
    (2020) Boncu, Tugba Eren; Guclu, Aylin Uskudar; Catma, Mehmet Faruk; Savaser, Ayhan; Gokce, Aysun; Ozdemir, Nurten; 0000-0002-1872-028X; 31678530; AAU-6196-2020
    In this study, it was aimed to formulate linezolid loaded electrospun PLGA and PCL fiber mats doing controlled drug release, to be used in the treatment and prophylaxis of the prosthesis related infections. The effect of PLGA concentration, PLGA to PCL ratio and the amount of linezolid on the fiber and mat properties were examined. Fiber diameter has been shown to increase with increasing amount of PLGA and linezolid. Increase in PLGA amount resulted in reduced linezolid release, whereas increase in linezolid amount resulted in increased drug release. All PLGA fiber mats have shown to have favorable encapsulation efficiency (>= 73%) and mechanical properties. Encapsulation efficiency and the mechanical properties deteriorated with the addition of PCL to the formulations. PLGA fiber mats have shown a biphasic controlled release and in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), pattern up to one month. The formulation selected as the optimum has been evaluated in vivo on the infected rats, which had prosthetic implantation after bone fracture. Consequently, it has been demonstrated microbiologically and histopathologically that a more efficient therapy and prophylaxis have been achieved with a 37-fold lower dose of linezolid.
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    The Power of Carbon Nanotubes on Sensitive Drug Determination Methods
    (2023) Bakirhan, Nurgul K.; Kaya, S. Irem; Jabbarov, Rasim; Gahramanova, Gulnaz; Abdullayeva, Sevda; Dedeoglu, Aylin; Ozkan, Cansel Kose; Savaser, Ayhan; Ozkan, Yalcin; Ozkan, Sibel A.; 34334078
    Nowadays, carbon nanotubes (CNTs) due to their inorganic conducting, semiconducting, and organic pi-pi stacking properties are becoming innovative materials. CNTs have an adjustable size, large surface area, and other significant chemical properties. Due to their excellent electrical, optical, and mechanical properties, CNTs play an important role in various application fields. In the past decade, many unique intrinsic physical and chemical properties have been intensively explored for pharmaceutical, biological, and biomedical applications. The functionalization of CNTs results in a remarkably reduced cytotoxicity and at the same time increased biocompatibility. The toxicity studies reveal that highly water-soluble and serum stable nanotubes are biocompatible, nontoxic, and potentially useful for biomedical applications. Ultrasensitive drug determination from its dosage form and/or biological samples with carbon nanotubes can be realized after surface modification. The main purpose of this review is to present recent achievements on CNTs which are investigated in electrochemical and chromatographically sensing technologies.