Browsing by Author "Sahin, Feride I."

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Chronic Tonsillitis Is Not Associated with Beta Defensin 1 Gene Polymorphisms in Turkish Population
(2015) Arslan, Fatih; Babakurban, Seda Turkoglu; Erbek, Selim S.; Sahin, Feride I.; Terzi, Yunus Kasim; 0000-0001-7308-9673; 0000-0001-5612-9696; 0000-0003-4825-3499; 0000-0001-5067-4044; 25683590; AAC-7232-2020; B-4372-2018; B-7604-2019; AAI-8856-2021
Background: Defensins are antimicrobial peptides expressed on mucosal surfaces. They function as part of the innate immune system. Palatine tonsils play important roles in innate immune system. However, our knowledge on the pathophysiology of chronic tonsils is limited. Objective: The aim of this study was to investigate the association between beta defensin 1 gene single nucleotide polymorphisms and chronic tonsillitis. Study design: Prospective, non-randomized, controlled clinical study. Setting: Tertiary referral center. Subjects and methods: Eighty six patients with chronic tonsillitis and eighty controls without history of chronic tonsillitis were enrolled in this study. Genotypes were determined by restriction fragment length polymorphism analyses after polymerase chain reaction. Results: Genotype and allele frequencies of the -20G/A (rs11362), -44C/G (rs1800972) and -52G/A (rs1799946) single nucleotide polymorphisms were not statistically different between patients and control groups (p > 0.05). Conclusion: In this study, we found that DEFB1 gene -20G/A, -44C/G and -52G/A single nucleotide polymorphisms were not associated with chronic tonsillitis. Studies, which analyse other polymorphism of the beta defensin 1 gene in large case series, should be conducted to understand the role of DEFB1 gene on chronic tonsillitis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Fractalkine Receptor Polymorphism and Chronic Tonsillitis
(2014) Babakurban, Seda Turkoglu; Erbek, Selim S.; Terzi, Yunus Kasim; Arslan, Fatih; Sahin, Feride I.; https://orcid.org/0000-0001-5067-4044; https://orcid.org/0000-0003-4825-3499; https://orcid.org/0000-0001-5612-9696; https://orcid.org/0000-0001-7308-9673; 24496565; AAI-8856-2021; B-7604-2019; B-4372-2018; AAC-7232-2020
The objective of this study is to examine whether there is an association of fractalkine gene receptor polymorphisms with chronic tonsillitis. This is a cross-sectional study in the setting of a tertiary referral center. The study group included 79 patients with chronic tonsillitis and 76 controls without history of chronic tonsillitis. Genotypes were identified by restriction fragment length polymorphism analyses after polymerase chain reaction. c.745G > A (V249I) single nucleotide polymorphism and the frequencies of the G and A alleles did not differ in the patient and control groups (p = 0.363; p = 0.743, respectively). c.839C > T (T280M) single nucleotide polymorphism was found to be higher in controls than in the patients with chronic tonsillitis (p < 0.001). Consistent with this result, T allele frequency was higher in controls than in the patients with chronic tonsillitis (p < 0.001). In this study, we suggested that fractalkine gene receptor c.839C > T (T280M) single nucleotide polymorphism could be associated with a reduced risk of chronic tonsillitis.
Fractalkine receptor polymorphism may not be associated with the development and clinical course of ulcerative colitis
(2015) Gokcan, Hale; Yurtcu, Erkan; Selcuk, Haldun; Sahin, Feride I.; 26042517
Fractalkine (CX3C), a chemokine expressed by epithelial cells within normal and inflamed colorectal mucosa, induces leukocyte adhesion and migration via fractalkine receptor. The aim of this study was to investigate two single nucleotide polymorphisms of the fractalkine receptor gene as a risk factor both for the development and clinical findings of ulcerative colitis. In this study, si patients with ulcerative colitis (UC) and 8o controls were recruited. Genotypes of fractalkine receptorc.743G>A (V249I) and c.839C>T (T280M) polymorphisms were identified by restriction fragment length polymorphism analyses after polymerase chain reaction.Genotype distribution and allele frequencies of V249I and T280M were not statistically significantly different between UC and control groups (p>0.05). No statistically significant relationship was found between fractalkine receptor polymorphisms and clinical findings of UC. We observed no significant difference in fractalldne receptor polymorphism between patients and control group and no genotype-phenotype relation. Therefore, we concluded that fractalkine receptor polymorphisms may not contribute to the molecular pathogenesis of UC.