Browsing by Author "Sade, L. E."

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    Cardiovascular Magnetic Resonance In Autoimmune Rheumatic Diseases: A Clinical Consensus Document By The European Association Of Cardiovascular Imaging
    (2022) Mavrogeni, S.; Pepe, A.; Nijveldt, R.; Ntusi, N.; Sierra-Galan, L. M.; Bratis, K.; Wei, J.; Mukherjee, M.; Markousis-Mavrogenis, G.; Gargani, L.; Sade, L. E.; Ajmone-Marsan, N.; Seferovic, P.; Donal, E.; Nurmohamed, M.; Cerinic, M. Matucci; Sfikakis, P.; Kitas, G.; Schwitter, J.; Lima, J. A. C.; 35808990
    Autoimmune rheumatic diseases (ARDs) involve multiple organs including the heart and vasculature. Despite novel treatments, patients with ARDs still experience a reduced life expectancy, partly caused by the higher prevalence of cardiovascular disease (CVD). This includes CV inflammation, rhythm disturbances, perfusion abnormalities (ischaemia/infarction), dysregulation of vasoreactivity, myocardial fibrosis, coagulation abnormalities, pulmonary hypertension, valvular disease, and side-effects of immunomodulatory therapy. Currently, the evaluation of CV involvement in patients with ARDs is based on the assessment of cardiac symptoms, coupled with electrocardiography, blood testing, and echocardiography. However, CVD may not become overt until late in the course of the disease, thus potentially limiting the therapeutic window for intervention. More recently, cardiovascular magnetic resonance (CMR) has allowed for the early identification of pathophysiologic structural/functional alterations that take place before the onset of clinically overt CVD. CMR allows for detailed evaluation of biventricular function together with tissue characterization of vessels/myocardium in the same examination, yielding a reliable assessment of disease activity that might not be mirrored by blood biomarkers and other imaging modalities. Therefore, CMR provides diagnostic information that enables timely clinical decision-making and facilitates the tailoring of treatment to individual patients. Here we review the role of CMR in the early and accurate diagnosis of CVD in patients with ARDs compared with other non-invasive imaging modalities. Furthermore, we present a consensus-based decision algorithm for when a CMR study could be considered in patients with ARDs, together with a standardized study protocol. Lastly, we discuss the clinical implications of findings from a CMR examination.
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    Determinants and Impact of New Persistent Atrial Fibrillation on Long-Term Outcome in Patients Receiving Cardiac Resynchronization Therapy
    (2014) Sade, L. E.; Atar, I.; Ozin, B.; Muderrisoglu, H.; https://orcid.org/0000-0003-3737-8595; https://orcid.org/0000-0002-9635-6313; AAQ-7583-2021; AAG-8233-2020
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    Evaluation of Left Ventricular Functions with Strain Echocardiography in Polycystic Ovary Syndrome Patients
    (2014) Aslan, G.; Aslan, R. C.; Sade, L. E.; Bal, U.; Onalan, G.; Zeyneloglu, H. B.; Kuscu, E.; Muderrisoglu, H.
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    Head to Head Comparison of T1 Mapping with Global Longitudinal Strain for the Detection of Acute Cellular Rejection in Heart Transplant Recipients
    (2018) Sade, L. E.; Hazirolan, T.; Kozan, H.; Ozdemir, H.; Hayran, M.; Eroglu, S.; Pirat, B.; Sezgin, A.; Muderrisolgu, H.; 0000-0003-3737-8595; 0000-0003-4576-8630; AAQ-7583-2021; ABG-1582-2021; AAI-8897-2021
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    Impact of Coronary Artery Disease Phenotype on Treatment in Chronic Coronary Syndromes: The EURECA Registry
    (2023) Liga, R.; Gimelli, A.; Podlesnikar, P.; Sredojevic, M.; Pontone, G.; Miglioranza, M. H.; Sumin, A.; Saraste, A.; Sia, C. H.; Sade, L. E.; Maroz-Vadalazhskaya, N.; Knuuti, J.; Popescu, B. A.; Delgado, V.; Neglia, D.
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    Impact of Weight Loss on Epicardial Fat and Carotid Intima Media Thickness After Laparoscopic Sleeve Gastrectomy: A Prospective Study
    (2018) Altin, C.; Erol, V; Aydin, E.; Yilmaz, M.; Tekindal, M. A.; Sade, L. E.; Gulay, H; Muderrisoglu, H.; https://orcid.org/0000-0002-3996-5681; https://orcid.org/0000-0003-3737-8595; https://orcid.org/0000-0002-0442-6178; https://orcid.org/0000-0003-0907-3647; https://orcid.org/0000-0002-9635-6313; https://orcid.org/0000-0002-2557-9579; 29571589; HGC-1839-2022; S-6973-2016; AAG-8233-2020; AAI-8276-2021; AAJ-6407-2021; AAQ-7583-2021
    Background and aims: Cardiovascular disease (CVD) is one of the leading causes of mortality in obese patients. We aimed to investigate the influence of significant weight loss following laparoscopic sleeve gastrectomy (LSG) on carotid intima media thickness (CIMT) and epicardial fat thickness (EFT) which are the independent predictors of subclinical atherosclerosis. Methods and results: Patients were recruited for standard indications. A total of 105 patients (79 women and 26 men) with the mean age of 43.61 +/- 12.42 were prospectively enrolled. On Bmode duplex ultrasound; the mean CIMT at the far wall of both left and right common carotid arteries were measured. EFT was measured on the free wall of the right ventricle at enddiastole from the parasternal long-axis view by standard transthorasic 2D echocardiography. Delta (Delta) values were obtained by subtracting sixth month values from the baseline values. Body mass index (BMI) was significantly reduced from 46.95 +/- 7.54 to 33.54 +/- 6.41 kg/m2 (p < 0.001) in sixth months after LSG. Both EFT and CIMT were significantly decreased after surgery (8.68 +/- 1.95 mm vs. 7.41 +/- 1.87 mm; p < 0.001 and 0.74 +/- 0.13 mm vs. 0.67 +/- 0.11 mm; p < 0.001 respectively). A significant correlation between Delta EFT and Delta MI (r = 0.431, p < 0.001) was shown. Delta CIMT is significantly correlated with Delta EFT, Delta BMI and Delta systolic blood pressure (r = 0.310, r = 0.285 and r = 0.231 respectively, p < 0.05 for all). In multivariate stepwise linear regression analysis; among variables only Delta BMI was the independent predictor of Delta EFT (beta = 153, p = 0.001). Conclusion: Early atherosclerotic structural changes may be reversed or improved by sustained weight loss after LSG in asymptomatic obese patients. (C) 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
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    Left Atrial Mechanics Predict Atrial Fibrillation in Patients After Cryptogenic Stroke
    (2018) Sade, L. E.; Colak, A.; Ciftci, O.; Can, U.; Kibaroglu, S.; Ozin, B.; Muderrisoglu, H.; 0000-0003-3737-8595; 0000-0001-8926-9142; 0000-0001-8689-417X; 0000-0002-3964-268X; 0000-0002-9635-6313; AAQ-7583-2021; W-5233-2018; AAJ-2999-2021; AAJ-2956-2021; AAG-8233-2020
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    Left Ventricular Contractile Function Assessed by 2D Strain is A Simple Surrogate of Recruitable Function and Predicts The Outcome After Cardiac Resynchronization Therapy
    (2014) Sade, L. E.; Atar, I.; Ozin, B.; Muderrrisoglu, H.; https://orcid.org/0000-0003-3737-8595; AAQ-7583-2021
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    Right Ventricular Adaptation and Subclinical Damage by Echocardiography in Heart Transplantation Recipients: Insights From Myocardial Work Index
    (2022) Sade, L. E.; Colak, A.; Sezgin, A.; Donal, E.; Butcher, S. C.; Pirat, B.; Eroglu, S.; Ozdemir, H.; Muderrisoglu, H.; 0000-0001-8258-8802; AED-3780-2022
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    Ti Mapping of the Right Ventricle in Heart Transplant Recipients: How Does It Correlate with Endomyocardial Biopsy Findings?
    (2022) Sade, L. E.; Colak, A.; Duzgun, S. A.; Hazirolan, T.; Sezgin, A.; Ozdemir, H.; Eroglu, S.; Pirat, B.; Muderrisoglu, H.