Browsing by Author "Pekoz, Burcak Cakir"

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Diffusion MR Imaging in Sporadic Creutzfeldt-Jakob Disease
(2014) Pekoz, Burcak Cakir; Alkan, Ozlem; Giray, Semih; Demir, Senay; Altinkaya, Naime; 0000-0001-7526-3460; 0000-0003-1348-8167; 0000-0002-4209-9075; 0000-0002-0722-3181; AAM-4169-2021; AAM-5169-2021; AAK-9310-2021; AAH-1091-2020
Creutzfeldt-Jakob disease (CJD) is a rare dementing disease and is thought to caused by a prion. It is characterized by rapidly progressive dementia, ataxia, myoclonus, akineticmutism and eventual death. Brain biopsy or autopsy is required for a definitive diagnosis of CJD. Diffusion-weighted imaging became an important tool for early diagnosis of CJD because of the high sensitivity. We present 59-year-old female patient diagnosed as sporadic CJD with typical MR imagings.
Diffusion-Weighted MRI in Cranial Bone Marrow Metastasis
(2015) Alkan, Ozlem; Pekoz, Burcak Cakir; Altinkaya, Naime
Purpose: Diffusion-weighted MR imaging (DW-MRI) is generally applied to diagnose intra-axial brain pathologies such as parenchyma metastasis, abscesses, and infarcts in patients with systemic cancer. This study aimed to evaluate the DW-MRI findings in cranial bone marrow metastases to facilitate diagnosis. Material and Methods: Conventional MR imaging and DW-MRI findings of 57 patients with cranial bone marrow metastases were evaluated retrospectively. These images were evaluated by two neuroradiologists for lesion detection and lesion consciousness. Reader agreement was assessed by. statistics. Results: Fifty-seven patients exhibited 113 cranial bone marrow metastases. The sensitivities of DW-MRI and the apparent diffusion coefficient to detect cranial bone metastasis for all types of primary malignancy were 86% and 90%, respectively. The sensitivities of T1-weighted imaging (T1WI), fluid attenuation inversion recovery, contrast-enhanced fat-suppressed (CE-FS) T1WI, and T2WI sequences to detect cranial bone metastasis were 93%, 90%, 89%, and 84%, respectively. Regarding lesion conspicuousness, DW-MRI was equivalent to CE-FS T1WI and equivalent or superior to non-contrast conventional sequences in most of the cranial bone marrow metastases. Interobserver agreement was excellent. Conclusions: DW-MRI is generally indicated not only to assess the diagnosis of parenchyma involvement, but also to discover the cranial bone marrow metastasis in patients with systemic cancer.
Intraneural Vascular Resistive Index of the Median Nerve as a Predictor of Severity of Carpal Tunnel Syndrome
(2020) Pekoz, Burcak Cakir; Pekoz, Mehmet Taylan; Analan, Pinar Doruk; 0000-0002-3528-3712; AAA-8043-2021
Objective: There is a limited data about resistive index (RI) of median nerve (MN) in patients with carpal tunnel syndrome (CTS). In our study, we aimed to evaluate the relationship between CTS severity and MN-RI. Methods: A total of 115 CTS patient wrists, and 49 wrists of control subjects without CTS, were examined on ultrasonography (US) and color Doppler US (CDUS), pulsed Doppler ultrasonography (PDUS), and by electrophysiological evaluations. MN peak-systolic velocity (MN-PSV), MN end-diastolic velocity, MN-RI and MN pulsatility index (MN-PI) were measured by PDUS. Patients were divided into 3 groups according to electrophysiological examinations severity findings of CTS as mild (Group-I), moderate (Group-II), and severe (Group-III). Results: MN-PSV, MN-PI and MN-RI increased significantly from Group-I to Group-III and these parameters were significantly higher in Group-III than other two groups. MN-RI independently determines the patients to have severe CTS. Increased MN-RI (per-0.1) was found to increase the risk of having severe CTS by 3.45-times. In the ROC analysis, the area under the curve was 0.846 for MN-RI. When the MN-RI cut-off value was taken as 0.80, it determines patients to be severe CTS with 85.2% sensitivity and 78.2% specificity. Conclusion: The increase in MN-RI in CTS patients is independently associated with disease severity and may be used in the clinical follow-up of these patients.
Quantitative elastography in differentiating benign and malignant breast lesions
(2016) Purbager, Aysin; Pekoz, Burcak Cakir; Aslan, Hulya; Agildere, Ahmet Muhtesem; 0000-0003-4223-7017; 0000-0002-7138-246X; AAB-5802-2020; AAK-9104-2021
Purpose: The purpose of this study was to evaluate the effectiveness of quantitative elastography in differentiating benign and malignant breast lesions that were detected by B-mode ultrasonography, to compare shear wave velocities of benign and malignant lesions, and to determine cut-off values differentiating malignant lesions from benign ones Material and Methods: In this prospective study we enrolled 254 breast lesions of 240 patients detected by B-mode ultrasonography, and underwent biopsy in our department. Shear wave elastography was performed to all lesions before biopsies. The patients who had radiotherapy or chemotherapy previously were not included. Elastography examinations were performed by one of the two radiologists specialising in breast radiology. The mean and median shear wave velocities, and standard deviation values were measured in meters/second. Both mean and median shear wave velocities were compared with histopathology results. Sensitivity, specificity, and the area under the curve were obtained by using a receiver operating characteristic curve analysis Results: The mean age of the patients, lesion size, mean and median shear wave velocities were significantly different between benign and malignant groups. The mean shear wave velocity of benign and malignant lesions were 3.59 +/- 1.2m/s and 5.59 +/- 1.9m/s, respectively. The cut-off value for the mean shear wave velocity was 4.08 m/s (71.6% sensitivity and 69.6% specificity) to differentiate malignant lesions from benign ones Conclusion: Quantitative elastography is an effective and complementary method making a significant contribution in differentiating benign and malignant lesions. In this respect, we believe that clinical usage of shear wave elastography should be generalized