Browsing by Author "Ozluoglu, Levent"

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ASSESSMENT OF MIDDLE EAR MECHANICS, INTERNAL EAR ACOUSTICAL EMISSION MEASUREMENTS AND HEARING IN RENAL TRANSPLANT RECIPIENTS
(2020) Oz, Isilay; Soy, Ebru H. Ayvazoglu; Sayin, Burak; Ozluoglu, Levent; Haberal, Mehmet
Audiological and vestibular measurements in Behcet's disease
(2019) Ertugrul, Ozlem; Mutlu, Ahmet; Zindanci, Ilkin; Cam, Osman Halit; Ozluoglu, Levent; 30929056; AAP-1533-2020
IntroductionBehcet's disease (BD) is a vasculitis that involves all small vessels and influences the multiple systems of the human body. This study aimed to evaluate the audio-vestibular system involvement of patients with BD and healthy individuals.Materials and methodsThis study was designed as a prospective case-control blinded study. Thirty-one patients with BD and 31 healthy individuals were included. All the subjects were evaluated via pure tone audiometry (PTA), video head impulse test (vHIT), post head shake nystagmus test (PHSNT) and dizziness handicap inventory (DHI) to check for audio-vestibular system involvement.ResultsPatients with BD showed higher PTA scores in both speech and high frequencies. The vHIT revealed pathological saccades, particularly in horizontal canals (right ear: p=0.002, left ear: p=0.039). The gain values of the patients were slightly lower than those of the control group; however, gain and gain asymmetry differed significantly in a few canals. In the spontaneous nystagmus test and PHSNT, pathological nystagmus was detected to be significantly higher in the patient group than control group (p=0.001); but the saccade presence in vHIT and nystagmus in PHNT did not differ among the patients (p=0.106). In addition, the DHI scores of the patients group were higher than those of the control group (p<0.001). No correlation was found between disease duration and saccade presence.ConclusionThe vHIT was used preliminary for evaluating the vestibular system in BD. This study showed the influence of BD on the audio-vestibular system, in particular isolated horizontal canal involvement was discovered in patients with BD.Level of evidenceLevel III b.
Auditory Brainstem Implant in Postlingual Postmeningitic Patients
(2016) Bayazit, Yildirim; Kosaner, Julie; Celenk, Fatih; Somdas, Mehmet; Yilmaz, Ismail; Altin, Gokhan; Cevizci, Rasit; Yavuz, Haluk; Ozluoglu, Levent; https://orcid.org/0000-0003-3320-204X; https://orcid.org/0000-0002-2150-0237; 26485185; F-6315-2015; AAI-8020-2021
Objectives/HypothesisThe aim of this study was to evaluate outcomes of postlingual postmeningitic patients who received an auditory brainstem implant (ABI). Study DesignRetrospective analysis was performed on postlingual postmeningitic patients with bilateral profound sensorineural hearing loss who underwent ABI between the years 2007 and 2014 MethodsAll patients were postlingually deaf due to cochlear ossification as a consequence of bacterial meningitis. The patients received a MED-EL or Neurelec ABI. All patients were operated on at different hospitals by the same primary surgeon. The patients were tested using Ling 5 sound detection, sound field implant thresholds between 250 Hz and 6 kHz, and 6 to 12 choice closed-set word and sentence tests. ResultsNine patients with postmeningitic cochlear ossification received an ABI. Five of nine ABI users (55.5%) wear their audio processors (AP) most of the time. Four (44.5%) with no perceivable benefit have become nonusers. Three of the five consistent ABI users reported good benefit. The other two ABI users who do wear their APs do not respond to sound in daily living but reported benefits such as feeling sound in a good way. ConclusionsIn this study, five of nine patients (55.5%) with bilateral ossified cochlea had some degree of benefit from their ABI. An ABI may be useful in hearing restoration in postlingual patients with bilateral ossified cochlea due to meningitis. However, poor results may be related to side effects, which may necessitate deactivation of electrodes, long duration of auditory deprivation, or impairments in the auditory neural structures as a result of meningitis. Level of Evidence4. Laryngoscope, 126:1889-1892, 2016
Hearing Status in Pediatric Renal Transplant Recipients
(2015) Gulleroglu, Kaan; Baskin, Esra; Aydin, Erdinc; Ozluoglu, Levent; Moray, Gokhan; Haberal, Mehmet; 0000-0001-6864-7378; 0000-0002-2150-0237; 0000-0002-3462-7632; 0000-0003-2498-7287; 0000-0003-1434-3824; 0000-0003-1434-3824; 0000-0003-4361-8508; 25365361; AAJ-2379-2021; AAI-8020-2021; AAJ-8097-2021; AAE-1041-2021; F-3294-2013; AAJ-8833-2021; B-5785-2018
Objectives: Renal transplant provides a long-term survival. Hearing impairment is a major factor in subjective health status. Status of hearing and the cause of hearing impairment in the pediatric renal transplant group have not been evaluated. Here, we studied to evaluate hearing status in pediatric renal transplant patients and to determine the factors that cause hearing impairment. Materials and Methods: Twenty-seven pediatric renal transplant recipients were investigated. All patients underwent audiologic assessment by means of pure-tone audiometry. The factors on hearing impairment were performed. Results: Sensorineural hearing impairment was found in 17 patients. There was marked hearing impairment for the higher frequencies between 4000 and 8000 Hz. Sudden hearing loss developed in 2 patients, 1 of them had tinnitus. Decrease of speech understanding was found in 8 patients. The cyclosporine level was significantly high in patients with hearing impairment compared with group without hearing impairment. Cyclosporine levels also were found to be statistically significantly high when compared with the group with decrease of speech understanding and the group without decrease of speech understanding. Similar relations cannot be found between tacrolimus levels and hearing impairment and speech understanding. Conclusions: Sensorineural hearing impairment prevalence was high in pediatric renal transplant recipients when compared with the general population of children. Cyclosporine may be responsible for causing hearing impairment after renal transplant. We suggest that this effect is a dose-dependent toxicity.
The Protective Effect of Adrenocorticotropic Hormone Treatment Against Noise-Induced Hearing Loss
(2018) Mutlu, Ahmet; Ocal, Fatma Ceyda Akin; Erbek, Seyra; Ozluoglu, Levent; 0000-0001-9022-921X; 0000-0002-8453-6069; 0000-0002-2150-0237; 29747961; AAI-2097-2019; AAJ-2445-2021; AAI-8020-2021
Objective: NIHL is a common problem, and steroids are the most effective treatment option. In this study, we aimed to evaluate the protective effects of the synthetic adrenocorticotropic hormone (ACTH) analogues, which induce endogenous steroid secretion, against noise-induced hearing loss (NIHL) and to compare their effectiveness with that of steroid treatment. Methods: Twenty-four male Sprague Dawley albino rats were divided into four subgroups as follows: group 1 (n = 6) control, group 2 (n = 6) saline, group 3 (n = 6) dexamethasone (2 mg/kg/ day intramuscularly [IM]), group 4 (n = 6) ACTH analogue (0,4 mg/kg/day IM), respectively. Three groups (groups 2-4) were exposed to white noise (105 dB SPL, 12 h). All the rats were evaluated for hearing thresholds of 10 kHz, 20 kHz, and 32 kHz via acoustic brainstem responses (ABR) measurement. After the basal threshold measurements, measurements were repeated immediately after the noise and on day 7 and day 21. Results: Both steroid and ACTH analogue groups showed significantly better hearing outcomes than the saline group on day 7 (p < 0.001) and day 21 (p < 0.001) after the noise exposure. No superior treatment effect was demonstrated in either the steroid or ACTH analogue group. None of the related intervention groups reached the basal hearing thresholds. Conclusion: Steroids were effective drugs for the treatment of NIHL. ACTH analogues also demonstrated promising therapeutic effects for NIHL. Further studies to establish ACTH analogues as an alternative NIHL treatment option to steroids are needed. (C) 2018 Elsevier B.V. All rights reserved.