Browsing by Author "Ozer, Huriye Eda Ozturan"

Filter results by typing the first few letters
Now showing 1 - 4 of 4
  • No Thumbnail Available
    Item
    Effect of Adipose-Derived Stem Cells on Colonic Anastomosis in Rats Immunosuppressed With Everolimus: An Experimental Study
    (2021) Karakaya, Emre; Akdur, Aydincan; Atilgan, Alev Ok; Uysal, Ahmet Cagri; Ozer, Huriye Eda Ozturan; Yildirim, Sedat; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0002-8726-3369; 34269651; AAJ-8097-2021; AAA-3068-2021
    Objectives: Immunosuppressed patients sometimes require colorectal surgery. We investigated whether adipose tissue-derived stem cells contributed to anastomosis healing in rats immunosuppressed with the mTOR inhibitor everolimus. Materials and Methods: Sixty male Sprague-Dawley rats were randomly divided into 4 groups of 14 each, with all groups undergoing descending colon anastomosis; the 4 remaining rats were used for stem cell retrieval. Group 1 (control) underwent surgery only, group 2 received stem cell injection, group 3 received everolimus only, and group 4 received everolimus plus stem cell injection. After treatment, each group was randomly divided into 2 equal subgroups according to the day of euthanasia (posttreatment day 4 or day 7). We measured anastomosis bursting pressure and tissue hydroxyproline level and performed histopathological evaluation. Results: At both posttreatment days 4 and 7, median weight loss in group 3 was higher than in group 1, group 3 had higher severity of intraabdominal adhesion than group 4, and group 2 had mean hydroxyproline level higher than the other groups. At posttreatment day 4, mean bursting pressure was significantly different in group 1 versus groups 2 and 4 (P = .002) and group 2 versus groups 3 and 4 (P < .001). No significant differences were shown in pathological analysis except for vascular proliferation on day 7 (P = .003). Conclusions: Injection of adipose tissue-derived stem cells in the anastomosis site prevented anastomosis leakage by contributing to healing. Injection of adipose tissue-derived stem cells in the anastomosis region, especially in the early period after solid-organ transplant in recipients and after gastrointestinal surgery in immunosuppressed patients, may help reduce mortality and morbidity.
  • No Thumbnail Available
    Item
    Effect of Mural or Intra-Arterial Injection Adipose Derived Stromal Fraction on TNBS-Induced Colitis: An Experimental Study
    (2019) Tugan, Tezcaner; Aydin, Huseyin Onur; Uysal, Cagri A.; Ozgun, Gonca; Ozer, Huriye Eda Ozturan; Ekici, Yahya; Haberal, Mehmet A.
  • No Thumbnail Available
    Item
    Effects of Adipose-Induced Stem Cell Application on Everolimus Immunosuppressed Rats on Colon Anastomosis: An Experimental Study
    (2018) Karakaya, Emre; Akdur, Aydincan; Atilgan, Alev Ok; Ozer, Huriye Eda Ozturan; Uysal, Cagri; Yildirim, Sedat; Haberal, Mehmet; 0000-0002-4879-7974; 0000-0002-8726-3369; 0000-0001-8595-8880; 0000-0002-5735-4315; 0000-0002-3462-7632; AAD-5466-2021; AAA-3068-2021; AAK-3333-2021; AAF-4610-2019; AAJ-8097-2021
  • No Thumbnail Available
    Item
    Effects of Adipose-Induced Stem Cell Application on Everolimus Immunosuppressed Rats on Colon Anastomosis: An Experimental Study
    (2018) Karakaya, Emre; Akdur, Aydincan; Atilgan, Alev Ok; Ozer, Huriye Eda Ozturan; Uysal, Cagri; Yildirim, Sedat; Haberal, Mehmet; https://orcid.org/0000-0002-4879-7974; https://orcid.org/0000-0002-8726-3369; https://orcid.org/0000-0001-8595-8880; https://orcid.org/0000-0002-5735-4315; https://orcid.org/0000-0002-3462-7632; AAD-5466-2021; AAA-3068-2021; AAK-3333-2021; AAF-4610-2019; AAJ-8097-2021