Browsing by Author "Ozdemir, Handan"

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Acute Rejection Patterns of Outbred Rats To Heterotopic Heart Xenotransplantation
(2016) Ozcay, Necdet; Haberal, Mehmet; Ozdemir, Handan
Approach To Optimal Assessment Of Right Ventricular Remodelling In Heart Transplant Recipients: Insights From Myocardial Work Index, T1 Mapping, And Endomyocardial Biopsy
(2023) Colak, Ayse; Duzgun, Selin Ardali; Hazirolan, Tuncay; Sezgin, Atilla; Donal, Erwan; Butcher, Steele C.; Ozdemir, Handan; Pirat, Bahar; Eroglu, Serpil; Muderrisoglu, Haldun; Sade, Leyla Elif; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0003-3737-8595; 35666833; X-8540-2019; AAQ-7583-2021
Aims Right ventricular (RV) dysfunction is an important cause of graft failure after heart transplantation (HTx). We sought to investigate relative merits of echocardiographic tools and cardiac magnetic resonance (CMR) with T1 mapping for the assessment of functional adaptation and remodelling of the RV in HTx recipients. Methods and results Sixty-one complete data set of echocardiography, CMR, right heart catheterization, and biopsy were obtained. Myocardial work index (MWI) was quantified by integrating longitudinal strain (LS) with invasively measured pulmonary artery pressure. CMR derived RV volumes, T1 time, and extracellular volume (ECV) were quantified. Endomyocardial biopsy findings were used as the reference standard for myocardial microstructural changes. In HTx recipients who never had a previous allograft rejection, longitudinal function parameters were lower than healthy organ donors, while ejection fraction (EF) (52.0 +/- 8.7%) and MWI (403.2 +/- 77.2 mmHg%) were preserved. Rejection was characterized by significantly reduced LS, MWI, longer T1 time, and increased ECV that improved after recovery, whereas RV volumes and EF did not change MWI was the strongest determinant of rejection related myocardial damage (area under curve: 0.812, P < 0.0001, 95% CI: 0.69-0.94) with good specificity (77%), albeit modest sensitivity. In contrast, T1 time and ECV were sensitive (84%, both) but not specific to detect subclinical RV damage. Conclusion Subclinical adaptive RV remodelling is characterized by preserved RV EF despite longitudinal function abnormalities, except for MWI. While ultrastructural damage is reflected by MWI, ECV, and T1 time, only MWI has the capability to discriminate functional adaptation from transition to subclinical structural damage.
Bridging Technique of Bile Duct Anastomosis Using An Expanded Polytetrafluoroethylene (Eptfe) Graft in A Porcine Model
(2016) Haberal, Mehmet; Ozdemir, Handan; Bacanli, Didem; Ozcay, Necdet; Ersoy, Zeynep; Torgay, Adnan; https://orcid.org/0000-0002-3462-7632; https://orcid.org/0000-0003-0767-1088; AAJ-8097-2021; AAF-3066-2021
A case of primer angiosarcoma in a young woman: lessons from multi-modality imaging
(2022) Coskun, Mehmet; Hasirci, Senem Has; Ozdemir, Handan; Coskun, Mehmet; Sezgin, Atilla; Muderrisoglu, I. Haldun; Sade, Leyla Elif; 0000-0002-7528-3557; X-8540-2019
Clinical impact of complement deposition findings on biopsies in acute rejection episodes of pediatric renal transplant patients
(2021) Gulleroglu, Kaan; Baskin, Esra; Ozdemir, Handan; Moray, Gokhan; Haberal, Mehmet; 0000-0003-1434-3824; 0000-0002-3462-7632; 34508854; AAJ-8833-2021; AAJ-8097-2021
Introduction: Rejection is the most important problem for renal graft function and survival. Complement system plays a key role in immune responses from host to graft. It was demonstrated that complement system activation is related with renal fibrosis. We evaluate clinical impact of complement deposition findings on biopsies in acute rejection episodes of pediatric renal transplant patients. Method: Demographics of the patients, graft functions, acute rejection episodes and graft loss were recorded from data files of 165 pediatric renal transplant patients. Findings of 98 renal biopsies were retrospectively evaluated. Results: Thirty three patients with kidney transplant had 44 acute rejection episodes (32 pure cellular acute rejection episodes / 1 pure humoral acute rejection episode / 11 combined acute cellular and acute humoral rejection episodes) proven by biopsy. C1q staining was positive in 7 biopsies, C3 staining in 15 biopsies and, C4d staining in 15 biopsies. 26 patients had graft fibrosis. All patients with a rejection history had a significant decrease in GFR value during follow-up. Patients who did not have fibrotic changes in first biopsy had same level of deterioration of GFR when compared with patients who had fibrotic changes in first biopsy. Conclusion: We could not demonstrate a significant relation between complement deposition and renal fibrosis, and between complement deposition and GFR values. Our data demonstrated that graft outcomes and graft loss after acute rejection episodes cannot be predicted only with complement deposition on graft or only with graft fibrosis.
Clinical Use of Tumor Markers for the Detection and Prognosis of Bladder Carcinoma: A Comparison of CD44, Cytokeratin 20 and Survivin
(2016) Yikilmaz, Taha Numan; Dirim, Ayhan; Ayva, Ebru Sebnem; Ozdemir, Handan; Ozkardes, Hakan; https://orcid.org/0000-0003-2898-485X; https://orcid.org/0000-0002-2280-8778; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0002-7277-449X; 27351322; AAJ-5689-2021; AAK-1967-2021; X-8540-2019; AAH-1052-2020
Purpose: To investigate the role of CD44, cytokeratin 20 (CK20) and survivin for the detection and prognosis of patients with urothelial carcinoma of the bladder. Materials and Methods: The study included 82 patients who underwent transurethral resection of bladder tumors between 2009 and 2014. The patient and tumor characteristics with relevance to age, tumor size and focality, grade and stage, recurrence and progression were noted. Patients with carcinoma in situ, those who had at more than 3 sites of lesions and greater than 3 cm tumors were excluded. All cases were ex-smokers. All histological samples stained with hematoxylin and eosin were re-evaluated according to the 2004 World Health Organization/International Society of Urological Pathology (WHO/ISUP) classification system and immunohistochemically stained for CD44, CK20 and survivin. Results: The study group comprised 57 (69.5%) males and 25 (30.5%) females with a mean age of 60 years (range, 26-87 years). All were newly-diagnosed patients with bladder tumors. Immunohistochemical evaluation revealed that there was a statistically significant correlation between the grade and stage of the tumor with CK20 and survivin positivity (P < .05). As the grade and stage increased CD44 immunoreactivity significantly decreased (P = .002, P = .0001, respectively). However, relationship of protein expressions with recurrence and progression remained insignificant (P > .05). Conclusion: In cases of bladder urothelial carcinoma positivity for CD44, CK20, and survivin has significant relation with the tumor grade and stage while no significant relationship was determined in terms of recurrence and progression
Comparison of Light and Electron Microscope Renal Biopsy Findings with Proteinuria Levels of Candidate Living Kidney Donors
(2016) Ozdemir, Handan; Ozdemir, Nurhan; Baskin, Esra; Haberal, Mehmet; https://orcid.org/0000-0002-5682-0943; https://orcid.org/0000-0003-4361-8508; https://orcid.org/0000-0002-3462-7632; AAK-1697-2021; B-5785-2018; AAJ-8097-2021
Eculizumab in the Treatment of Dense Deposit Disease
(2015) Gulleroglu, Kaan; Avci, Begum; Kantar, Asli; Ozdemir, Handan; Baskin, Esra; 0000-0002-5375-379X; 0000-0003-1434-3824; 0000-0002-7528-3557; 0000-0003-1434-3824; 0000-0003-4361-8508; GYU-5220-2022; AAJ-8833-2021; X-8540-2019; F-3294-2013; B-5785-2018
The Effects of Glucose and Fructose on Body Weight and Some Biochemical Parameters in Rats
(2018) Koseler, Esra; Kiziltan, Gul; Turker, Perim Fatma; Saka, Mendane; Ok, Mehtap Akcil; Bacanli, Didem; Aydos, Tolga Resat; Bayraktar, Nilufer; Ozdemir, Handan; 0000-0002-4254-3711; 0000-0002-1832-9336; 0000-0002-7886-3688; AAZ-8170-2020; AAJ-7279-2020; Y-8758-2018
Objective: Dietary fructose from added sugar as high fructose corn syrup may causes major risks in obesity, hyperlipidemia, cardiovascular diseases, hyperuricemia and fatty liver. The aim of this study was to investigate and compare the effects of high fructose and high glucose intake on body weight and some biochemical parameters in rats. Subject and methods: The study was conducted on adult, 32 Wistar albino male rats (300-350 g weeks) which fed with standard laboratory chow. In each group, 8 rats was selected randomly and which was be composed four groups. The rats in each group, in addition to standard meal, different amount of glucose and fructose containing solutions (10% and 30% glucose-fed group, 10% and 30% fructose-fed group) was given by oral gavage for 6 weeks. At baseline and after 6 weeks total cholesterol, VLDL-cholesterol, triglycerides, uric acid, AST and ALT as biochemical parameters and liver histopathological examination of rats were determined. Body weight of the rats was evaluated every week. Results: The 30% fructose group caused higher AST levels according to 10% glucose group, 30% glucose group and 10% fructose group. At the end of 6 weeks, the mean body weight in the fructose-fed groups was higher than the glucose-fed groups (p>0.05). No statistically significant difference between rat groups' portal inflammation rates were found and the moderate and severe ballooning were observed in 30% fructose rats (p<0.05). Conclusions: As a result, dietary fructose from added sugar as high fructose corn syrup may causes major metabolic disorders.
Effects of Late Acute Rejection on Graft Survival and Outcome in Pediatric Renal Transplant Recipients
(2015) Baskin, Esra; Kantar, Asli; Gulleroglu, Kaan; Ozmen, Esra; Ozdemir, Handan; Kirnap, Mahir; Moray, Gokhan; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0002-7528-3557; 0000-0003-2498-7287; 0000-0003-1434-3824; 0000-0003-4361-8508; /0000-0003-1434-3824; AAJ-8097-2021; X-8540-2019; AAE-1041-2021; F-3294-2013; B-5785-2018; AAH-9198-2019; AAJ-8833-2021
Expanded Criteria for Hcc in Liver Transplantation
(2017) Haberal, Mehmet; Akdur, Aydincan; Moray, Gokhan; Arslan, Gulnaz; Ozcay, Figen; Selcuk, Haldun; Ozdemir, Handan; 0000-0002-3462-7632; 0000-0002-8726-3369; 0000-0003-2498-7287; 0000-0002-5214-516X; 0000-0002-8445-6413; 0000-0002-7528-3557; AAJ-8097-2021; AAA-3068-2021; AAE-1041-2021; ABG-5684-2020; AAJ-6976-2021; X-8540-2019
Expanded Criteria for Hepatocellular Carcinoma in Liver Transplant
(2017) Haberal, Mehmet; Akdur, Aydincan; Moray, Gokhan; Arslan, Gulnaz; Ozcay, Figen; Selcuk, Haldun; Ozdemir, Handan; 0000-0002-7528-3557; 0000-0003-2498-7287; 0000-0002-8726-3369; 0000-0002-3462-7632; 0000-0002-8445-6413; 0000-0002-5214-516X; 28302000; X-8540-2019; AAE-1041-2021; AAA-3068-2021; AAJ-8097-2021; AAJ-6976-2021; ABG-5684-2020
Objectives: Hepatocellular carcinoma is the sixth most common cancer worldwide and is the third highest cause of malignancy-related death. Because of its typically late diagnosis, median survival is ap proximately 6 to 20 months, with 5-year survival of < 12%. Hepatocellular carcinoma typically arises in the background of cirrhosis, with liver transplant regarded as the optimal therapy for selected patients. Initially, orthotopic liver transplant was limited to patients with extensive unresectable tumors, resulting in uniformly dismal outcomes due to high tumor recurrence rates. Here, we evaluated our long-term results with expanded-criteria liver transplant. Materials and Methods: From December 1988 to January 2017, we performed 552 liver transplants at Baskent University. In candidates with hepatocellular carcinoma, our expanded criteria for liver transplant is applied regardless of tumor size and number, includes those without major vascular invasion and without distant metastasis, and those with negative cytology (if the patient has ascites). Since 1994, of 61 liver transplants for hepatocellular carcinoma, 36 patients received transplants according to our expanded criteria. Results: Of 36 expanded-criteria patients, 11 were children and 25 were adults. Sixteen patients (4 pediatric, 12 adult) were within our expanded criteria both radiologically and pathologically before trans plant. The other 20 patients (7 pediatric, 13 adult) were within Milan criteria radiologically before transplant; however, after liver transplant, when pathologic specimens were evaluated, patients were found to be within our center's expanded criteria. During follow-up, 9/36 patients (25%) had hepatocellular carcinoma recurrence. In pediatric patients, 5-year and 10-year survival rates were 90%; in adults, 5-year survival was 58.7% and 10-year survival was 49.7%. Overall 5-year and 10-year survival rates were 71.7% and 62.7%. Conclusions: Liver transplant is safe and effective in patients with hepatocellular carcinoma in com bination with interventional radiology procedures, regardless of tumor size and number, without major vascular invasion and distant metastasis.
Extensive Indications for HCC in Living Donor Liver Transplantation
(2016) Haberal, Mehmet; Akdur, Aydincan; Moray, Gokhan; Arslan, Gulnaz; Ozcay, Figen; Selcuk, Haldun; Ozdemir, Handan; https://orcid.org/0000-0002-3462-7632; https://orcid.org/0000-0002-8726-3369; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-5214-516X; https://orcid.org/0000-0002-8445-6413; AAJ-8097-2021; AAA-3068-2021; AAE-1041-2021; ABG-5684-2020; AAJ-6976-2021
Head to Head Comparison of Speckle Tracking Strain Echocardiography with Invasive Hemodynamic Assessment for the Detection of Acute Cellular Rejection in Cardiac Allograft Recipients
(2018) Sade, Leyla Elif; Eroglu, Serpil; Pirat, Bahar; Sezgin, Atilla; Aydinalp, Alp; Ozdemir, Handan; Muderrisoglu, Haldun; 0000-0003-3737-8595; 0000-0003-4576-8630; 0000-0002-3761-8782; 0000-0002-7528-3557; AAQ-7583-2021; ABG-1582-2021; AAI-8897-2021; AAD-5841-2021; X-8540-2019
Histopathologic Appearance of an Outbred Mouse to Rat Strain Combination on Kidney Xenotransplantation
(2017) Ozcay, Necdet; Ozdemir, Handan; https://orcid.org/0000-0002-7528-3557; X-8540-2019
The Importance of Renal Biopsy in Candidate Living Donors with Proteinuria
(2016) Ozdemir, Handan; Ozdemir, Gokce; Terzi, Aysen; Ozdemir, Nurhan; Tepeoglu, Merih; Moray, Gokhan; Haberal, Mehmet; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0003-2545-0078; https://orcid.org/0000-0002-1225-1320; https://orcid.org/0000-0002-5682-0943; https://orcid.org/0000-0002-9894-8005; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-3462-7632; X-8540-2019; AAL-4282-2020; F-7546-2013; AAK-1697-2021; AAK-5222-2021; AAE-1041-2021; AAJ-8097-2021
Interactive Effects of Acupuncture on Pain and Distress in Major Burns: An Experiment with Rats
(2015) Abali, Ayse Ebru; Cabioglu, Tugrul; Ozdemir, Handan; Haberal, Mehmet; 0000-0002-1298-7944; 0000-0002-3462-7632; 0000-0002-7528-3557; 25433758; AAE-8704-2021; AAJ-8097-2021; X-8540-2019
This study sought to investigate the interactive effects of acupuncture on pain and distress and the local progress in the burn wound in an experimental major burn model. Forty-eight male Sprague-Dawley rats were divided into six groups: S group (sham/observation during 7 days after injury); SA group (sham/acupuncture/observation during 7 days after injury); Si group (burns/observation during 1 h after injury); BA1 group (burns/acupuncture/observation during 1 h after injury); 57 group (burns/observation during 7 days after injury); and BA7 group (burns/acupuncture/observation during 7 days after injury). Pain and distress scores were evaluated throughout the study. The amounts of neutrophils and mononuclear cells were evaluated semiquantitatively, and the number of microvessels was evaluated quantitatively. Our data indicated that the average pain score of BA7 group was significantly lower than the other study groups. Histopathologic investigations indicate that the amounts of neutrophil and mononuclear cell and numbers of microvessels in the unburned skin were higher in acupuncture-applied groups. The number of microvessels in burn wounds of BA7 group was significantly higher than that of the other groups. Our data suggest that acupuncture provides low pain and distress scores in experimental rat model, and it contributes to wound healing with an enhanced angiogenesis during the acute phase of burns. Future clinical and experimental studies should be conducted to discern the benefits from acupuncture in pain management of burn patients. (C) 2014 Elsevier Ltd and ISBI. All rights reserved.
Liver Transplantation and Auxiliary Partial Orthotopic Transplantation Outcomes in Wilson's Disease: Results of a Single Center
(2018) Soy, Ebru H. Ayvazoglu; Akdur, Aydincan; Moray, Gokhan; Boyacioglu, Sedat; Torgay, Adnan; Arslan, Gulnaz; Ozdemir, Handan; Haberal, Mehmet; https://orcid.org/0000-0002-0993-9917; https://orcid.org/0000-0002-8726-3369; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-9370-1126; https://orcid.org/0000-0002-6829-3300; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0002-3462-7632; AAC-5566-2019; AAA-3068-2021; AAE-1041-2021; AAE-7637-2021; AAJ-5221-2021; X-8540-2019; AAJ-8097-2021
Long-Term Results of Kidney Transplantation in Patients with Familial Mediterranean Fever
(2023) Bitik, Berivan; Hatipoglu, Bugra; Sayin, Burak; Kanbur, Aysenur Yalcintas; Bursa, Nurbanu; Oygur, Cagdas Sahap; Ozdemir, Handan; Colak, Turan; Haberal, Mehmet; Yucel, Ahmet Eftal; 0000-0001-5803-915X; 0000-0002-7528-3557; 0000-0002-3462-7632; 0000-0002-0168-2993; 36544375; AAI-9195-2021; X-8540-2019; AAJ-8097-2021
IntroductionLong-term kidney transplantation (KT) results in patients with familial Mediterranean fever (FMF)-related amyloidosis are not well studied. This study reviewed the long-term survival outcomes of FMF patients who underwent KT. MethodsWe compared the outcomes of 31 patients who underwent (KT) for biopsy-proven amyloidosis secondary to FMF with 31 control patients (five with diabetes mellitus and 26 with nondiabetic kidney disease) undergoing KT between 1994 and 2021 at Baskent University Hospital. All data were recorded retrospectively from patients' files. Results: The median age (quartile deviationQD) at the time of KT in the FMF and control group were 31 (6.7) and 33 (11), respectively. The median follow-up period (QD) after KT was 108 (57) months in the FMF and 132 (72) months in the control group. In the FMF group, graft and patient survivals were 71% and 84% at 5 years and 45% and 48% at 10 years, respectively. In the control group, graft and patient survivals were 79% and 100% at 5 years and 63% and 71% at 10 years, respectively. Patient survival in the FMF group at 5 years was significantly lower than in the control group (p = .045). There was no statistically significant difference between the FMF and control groups in terms of graft and patient survival, and serum creatinine levels at 10 years. All patients were given triple immunosuppressive treatment with cyclosporine, mycophenolate mofetil, and prednisolone. Three patients received anakinra and one received canakinumab in addition to colchicine treatment. One FMF patient also underwent heart transplantation due to AA amyloidosis. Of the FMF patients, 11 died during follow-up. ConclusionWe have found that the long-term outcome of KT in patients with FMF amyloidosis is numerically worse but not statistically different from the control group. However, short- and long-term complications still need to be resolved.
Outcomes of Patients With Hepatocellular Carcinoma After Liver Transplant
(2015) Moray, Gokhan; Kirnap, Mahir; Akdur, Aydincan; Soy, Ebru; Tezcaner, Tugan; Boyvat, Fatih; Ozdemir, Handan; Haberal, Mehmet; 0000-0002-0993-9917; 0000-0002-8726-3369; 0000-0002-3462-7632; 0000-0002-3641-8674; 0000-0003-2498-7287; 0000-0002-7528-3557; 26640906; AAC-5566-2019; AAA-3068-2021; AAJ-8097-2021; AAD-9865-2021; F-4230-2011; AAH-9198-2019; AAE-1041-2021; X-8540-2019
Objectives: Liver transplant is one of the few effective treatments for hepatocellular carcinoma. Our aim in this study was to evaluate the risk factors for hepatocellular carcinoma recurrence after liver transplant. Materials and Methods: In this retrospective study, conducted between October 1988 and March 2015, four hundred seventy-three liver transplants were performed at our institution. Of these, 231 were pediatric and 242 were adult. Among these patients, liver transplant was performed in 58 patients (12.3%) for treatment of hepatocellular carcinoma. Results: Hepatocellular carcinoma recurrence was detected in 14 patients (24.1%). Overall 5-year and 10-year survival rates of patients underwent liver transplant beyond the Milan criteria for hepatocellular carcinoma were 50.3% and 43.1%. Overall, 5- and 10-year survival rates of patients underwent liver transplant within the Milan criteria for hepatocellular carcinoma were 78.4% and 72.6%. The main predictive variable was whether the tumor had expensed beyond the Milan criteria. Conclusions: As expected, outcomes were significantly better in the Milan criteria group. Although the overall- and disease-free survival rates were promising in such a group of patients who had no better chance, it could be asserted that liver transplant is a safe and effective treatment option with promising results, even if the tumor expanse is beyond the Milan criteria.