Browsing by Author "Ozdemir, Gokce"

Now showing 1 - 11 of 11

Impact of Vitamin D3 on Cytoskeletal Reorganization and Regulation of Adherens Junctions of Tubule Cells: Epithelial to Mesenchymal Transition and Development of Interstitial Fibrosis in Renal Allografts
(2018) Ozdemir, B. Handan; Ozdemir, Fatma Nurhan; Ayva, Ebru Sebnem; Akcay, Eda Yilmaz; Soy, Ebru H. Ayvazoglu; Ozdemir, Gokce; Polat, Aysegul Yucel; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-5682-0943; 0000-0002-2280-8778; 0000-0002-0993-9917; 0000-0003-2545-0078; 0000-0002-3462-7632; X-8540-2019; AAK-1697-2021; AAK-1967-2021; AAC-5566-2019; AAL-4282-2020; AAJ-8097-2021
The Importance of Renal Biopsy in Candidate Living Donors with Proteinuria
(2016) Ozdemir, Handan; Ozdemir, Gokce; Terzi, Aysen; Ozdemir, Nurhan; Tepeoglu, Merih; Moray, Gokhan; Haberal, Mehmet; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0003-2545-0078; https://orcid.org/0000-0002-1225-1320; https://orcid.org/0000-0002-5682-0943; https://orcid.org/0000-0002-9894-8005; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-3462-7632; X-8540-2019; AAL-4282-2020; F-7546-2013; AAK-1697-2021; AAK-5222-2021; AAE-1041-2021; AAJ-8097-2021
De Novo Thrombotic Microangiopathy in Renal Transplant Patients
(2018) Ozdemir, B. Handan; Atilgan, Alev Ok; Akcay, Eda Yilmaz; Ozdemir, Gokce; Soy, Ebru Ayvazoglu; Akdur, Aydincan; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0001-8595-8880; 0000-0001-6831-9585; 0000-0003-2545-0078; 0000-0002-0993-9917; 0000-0002-8726-3369; 0000-0002-3462-7632; 29528010; X-8540-2019; AAK-3333-2021; AAK-1960-2021; AAL-4282-2020; AAC-5566-2019; AAA-3068-2021; AAJ-8097-2021
Objectives: Thrombotic microangiopathy is a form of renal capillary injury possibly associated with calcineurin inhibitor toxicity, acute humoral rejection, infections, and recurrent diseases. Here, we examined its incidence in patients diagnosed with acute and chronic active humoral rejection, polyomavirus nephropathy, acute cellular rejection, and immunoglobulin A recurrence. Materials and Methods: In total, 272 renal allograft recipients who met the inclusion criteria were reevaluated for presence of renal thrombotic microangiopathy. Thrombotic microangiopathy diagnosis was established by clinical, laboratory, and histologic features. C4d expression in peritubular capillaries was determined. Clinical data were collected from medical records. Results: Of 272 patients (mean age of 42.8 +/- 12.7 years), only 74 patients (27.2%) had de novo thrombotic microangiopathy, which was found in 30/90 patients (33.3%) with acute humoral rejection, 9/51 (17.6%) with acute cellular rejection, 22/53 (41.5%) with chronic active humoral rejection, 10/55 (18.2%) with polyomavirus nephropathy, and 3/23 (13%) with immunoglobulin A nephropathy. Significant differences were shown between therapy type and thrombotic microangiopathy development (P= .02). Patients who received cyclosporine (38.5%) tended to show higher incidence of thrombotic microangiopathy than patients who received tacrolimus (20.7%) or sirolimus (7.7%). Patients with C4d-positive acute humoral (97.6% vs 2.4%) and chronic active humoral rejection (68.2% vs 31.8%) had greater incidence of thrombotic microangiopathy versus those who were C4d-negative. Graft loss was significantly higher in C4d-positive than in C4d-negative thrombotic microangiopathy groups (P < .001). Overall 1-, 3-, and 5-year graft survival was 94%, 85%, and 85% versus 83%, 51%, and 51% in thrombotic microangiopathy-negative versus thrombotic microangiopathy-positive patients (P < .001). Conclusions: Acute humoral rejection and chronic active humoral rejection were the most common and therefore most important causes of de novo thrombotic microangiopathy in renal transplant patients. Its presence in the renal allograft biopsy should arouse suspicion for underlying acute or chronic active humoral rejection.
Pretransplant Renal Arterial Vasculopathy of Donor Predicts Poor Renal Allograft Survival
(2018) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Borcek, Pelin; Sercan, Cigdem; Ozdemir, Gokce; Soy, Ebru H. Ayvazoglu; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-5682-0943; 0000-0003-2545-0078; 0000-0002-0993-9917; 0000-0002-3462-7632; 29527990; X-8540-2019; AAK-1697-2021; AAL-4282-2020; AAC-5566-2019; AAJ-8097-2021
Objectives: Transplant vasculopathy is a significant predictor of poor outcome. We investigated whether age or pretransplant renal arterial vasculopathy of grafted kidneys affected allograft survival. Materials and Methods: This study included 148 recipients and their donors. All donors underwent pretransplant renal arterial biopsy, with renal artery vascular score determined for each artery. Chronic rejection and graft loss were noted for all patients. Results: Variable grades of pretransplant renal arterial lesions were noted in 103 donors (69.6%). A positive correlation was found between donor age and renal artery score (r = 0.650, P < .001), and chronic rejection and graft loss were found to increase with increasing score (P < .001). Recipient and donor age was significantly associated with graft loss and chronic rejection. With either younger or older donors, recipients had similar and best results regarding chronic rejection and graft loss if donors had renal artery scores of 0 or 1, but worse effects if donors had scores of 2 or 3. Five-year allograft survival rates for scores of 0, 1, 2, and 3 were 91%, 68%, 46%, and 33%. Univariate analyses showed that acute rejection episode (relative risk: 2.729, 95% confidence interval, 1.496-4.977; P= .001), older (>= 50 y) donor age (relative risk: 1.970, 95% confidence interval, 1.038-3.736; P = .04), and donor renal artery score (relative risk: 2.466, 95% confidence interval, 1.382-4.401; P = .002) were associated with decreased allograft survival. Multivariate Cox analysis showed that only acute rejection episode (relative risk: 3.585, 95% confidence interval, 1.781-7.217; P < .001) and renal artery score (relative risk: 2.642; 95% confidence interval, 1.355-5.150; P = .004) were independent predictors of allograft survival. Conclusions: Pretransplant vasculopathy in donor renal artery implies a poor prognosis for renal allograft survival and is independent of other risk factors. Pretransplant renal artery biopsy is recommended for both deceased and living donors, and therapeutic interventions to modify transplant vasculopathy progression should start early posttransplant in recipients with affected renal arteries.
Rearrangement of the Endothelial Cell Cytoskeleton in Glomerular and Peritubular Capillaries (PTCS) Following Antibody-Mediated Rejection (AMR): Its Significance on the Development of Transplant Glomerulopathy and Interstitial Fibrosis
(2018) Ozdemir, B. Handan; Acar, F. Nurhan Ozdemir; Ayva, Sebnem; Akcay, Eda; Soy, Ebru H. Ayvazoglu; Ozdemir, Gokce; Haberal, Mehmet; https://orcid.org/0000-0003-2545-0078; https://orcid.org/0000-0002-5682-0943; https://orcid.org/0000-0002-2280-8778; https://orcid.org/0000-0001-6831-9585; https://orcid.org/0000-0002-0993-9917; https://orcid.org/0000-0003-2545-0078; https://orcid.org/0000-0002-3462-7632; AAL-4282-2020; AAK-1697-2021; AAK-1967-2021; AAK-1960-2021; AAC-5566-2019; AAL-4282-2020; AAJ-8097-2021
Renal Allograft With Calcium Oxalate Deposition: Association with Urinary Tract Infection and Development of Interstitial Fibrosis
(2018) Ozdemir, B. Handan; Ayva, Sebnem; Ozdemir, Gokce; Atilgan, Alev Ok; Ozdemir, F. Nurhan; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-2280-8778; 0000-0003-2545-0078; 0000-0001-8595-8880; 0000-0002-5682-0943; 0000-0002-3462-7632; 29528009; X-8540-2019; AAK-1967-2021; AAL-4282-2020; AAK-3333-2021; AAK-1697-2021; AAJ-8097-2021
Objectives: The interaction between calcium oxalate deposition and urinary tract infection is not well established. We aimed to identify the association between these and to determine the role of calcium oxalate deposition on interstitial fibrosis development. Materials and Methods: Renal allograft biopsies of 967 patients were reviewed to identify those with calcium oxalate deposition in the renal allograft, with 27 (2.8%) identified. Follow-up biopsies were conducted to reevaluate for calcium oxalate presence and interstitial fibrosis development. At time of biopsy, presence of urinary tract infection and oxaluria was also examined from medical records. Results: Mean time for development of calcium oxalate deposition in renal allografts was 1.7 +/- 0.4 and 32.7 +/- 21.6 months in patients with primary and secondary oxalosis, respectively (P < .001). Of 27 patients with calcium oxalate deposition, 7 (25.9%) showed tubulointerstitial nephritis, with 2 also having urinary tract infection. Four patients (14.8%) had only urinary tract infection. Causes of tubulointerstitial nephritis were secondary to bacterial infection in 2 and secondary to viral infection in 5 patients (2 polyomaviruses, 2 cytomegaloviruses, 1 adenovirus). Time until development of interstitial fibrosis after calcium oxalate deposition was 3.5 +/- 2.1 and 10.3 +/- 4.1 months in patients with primary and secondary oxalosis, respectively (P = .01). Time until graft loss after calcium oxalate deposition was 9.3 +/- 7.8 and 21.8 +/- 12 months in those with primary and secondary oxalosis (P < .001), with 1-, 3-, and 5-year kidney graft survival of 43%, 28%, and 0% and 100%, 100%, and 67% in those with primary and secondary oxalosis, respectively. Conclusions: Calcium oxalate deposits increased the risk of urinary tract infection and tubulointerstitial nephritis, with bacteria inducing increased presence of calcium oxalate deposition in a renal allograft. Calcium oxalate deposition had a significant influence on interstitial fibrosis development, therefore negatively affecting graft survival.
Renal Allograft with Calcium Oxalate Deposition: Its Association with Urinary Tract Infection and Development of Interstitial Fibrosis
(2016) Ozdemir, Handan; Ozdemir, Gokce; Ayva, Sebnem; Ozdemir, Nurhan; Borcek, Pelin; Moray, Gokhan; Haberal, Mehmet; https://orcid.org/0000-0003-2545-0078; https://orcid.org/0000-0002-2280-8778; https://orcid.org/0000-0002-5682-0943; https://orcid.org/0000-0003-2498-7287; https://orcid.org/0000-0002-3462-7632; AAL-4282-2020; AAK-1967-2021; AAK-1697-2021; AAE-1041-2021; AAJ-8097-2021
Sequential Biopsy Findings of Polyomavirus Associated Nephropathy
(2016) Ozdemir, Handan; Ozdemir, Nurhan; Terzi, Aysen; Ayva, Sebnem; Akcay, Eda Yilmaz; Arslan, Hande; Ozdemir, Gokce; Haberal, Mehmet; https://orcid.org/0000-0002-7528-3557; https://orcid.org/0000-0002-5682-0943; https://orcid.org/0000-0002-1225-1320; https://orcid.org/0000-0002-2280-8778; https://orcid.org/0000-0001-6831-9585; https://orcid.org/0000-0002-5708-7915; https://orcid.org/0000-0003-2545-0078; https://orcid.org/0000-0002-3462-7632; X-8540-2019; AAK-1697-2021; F-7546-2013; AAK-1967-2021; AAK-1960-2021; ABG-7034-2021; AAL-4282-2020; AAJ-8097-2021
Significance of Antibody-Mediated Vascular Rejection (AMVR) on Graft Survival: Correlation with Pure Antibody-Mediated Rejection (AMR)
(2018) Ozdemir, B. Handan; Acar, F. Nurhan Ozdemir; Terzi, Aysen; Ozdemir, Gokce; Atilgan, Alev Ok; Soy, Ebru H. Ayvazoglu; Akdur, Aydincan; Moray, Gokhan; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-5682-0943; 0000-0002-1225-1320; 0000-0003-2545-0078; 0000-0001-8595-8880; 0000-0002-0993-9917; 0000-0002-8726-3369; 0000-0003-2498-7287; 0000-0002-3462-7632; X-8540-2019; AAK-1697-2021; F-7546-2013; AAL-4282-2020; AAK-3333-2021; AAC-5566-2019; AAA-3068-2021; AAE-1041-2021; AAJ-8097-2021
Traumatic Neuroma Causing Biliary Stricture After Orthotopic Liver Transplant, Treated With Hepaticojejunostomy: A Case Report
(2017) Terzi, Aysen; Kirnap, Mahir; Sercan, Cigdem; Ozdemir, Gokce; Ozdemir, Binnaz Handan; Haberal, Mehmet; 0000-0002-1225-1320; 0000-0003-2545-0078; 0000-0002-7528-3557; 0000-0002-3462-7632; 28260461; F-7546-2013; AAL-4282-2020; X-8540-2019; AAJ-8097-2021
Traumatic neuromas of the biliary tract have occasionally been reported to cause strictures at the cystic duct stump as a late complication of cho-lecystectomy with common bile duct exploration. The incidence of symptomatic traumatic biliary neuroma appears to be low after orthotopic liver transplant, as only 25 patients have been described previously in the English-language literature. Traumatic (amputation) neuroma is a reactive proliferation of pericholangial nerve fibers induced by injury, but it is not a true neoplasm. The diagnosis of traumatic neuroma is possible only by histopathologic examination; the diagnostic finding is a mass of hyperplastic nerve bundles. We report a patient with a traumatic neuroma causing an early biliary stricture with intrahepatic extension after an orthotopic liver transplant. The lesion failed to respond to repeated endoscopic stenting and eventually required hepaticojejunostomy. A biopsy of the liver graft, performed in the 13th month after transplant, showed chronic ductopenic rejection.
What Is The Role of Cytomegalovirus on Interstitial Fibrosis and Graft Survival?
(2016) Ozdemir, Handan; Ozdemir, Nurhan; Baskin, Esra; Ozgun, Gonca; Ozdemir, Gokce; Haberal, Mehmet; https://orcid.org/0000-0002-5682-0943; https://orcid.org/0000-0003-4361-8508; https://orcid.org/0000-0003-2545-0078; https://orcid.org/0000-0002-3462-7632; AAK-1697-2021; B-5785-2018; AAL-4282-2020; AAJ-8097-2021