Browsing by Author "Ozdemir, F. Nurhan"

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The Age of the Recipient and the Ratio of CD4/CD8 in Renal Allografts Influences the Prognosis and the Presenting Time of the Polyoma Virus-Associated Nephropathy (PVAN)
(2022) Ozdemir, B. Handan; Akcay, Eda Yilmaz; Ozdemir, F. Nurhan; Baskin, Esra; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0001-6831-9585; AAJ-8097-2021; AAK-1960-2021
The Beneficial Impact of D3 Vitamin on the Decline of Rejection, Epithelial-Mesenchymal Transition (EMT), And Interstitial Fibrosis Among Pediatric Renal Transplant Patients
(2022) Akcay, Eda Yilmaz; Ozdemir, B. Handan; Baskin, Esra; Ozdemir, F. Nurhan; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0001-6831-9585; AAJ-8097-2021; AAK-1960-2021
Comparison of Pediatric Patients with Pure Antibody-Mediated Rejection (Amr) and Recipients with Both Amr and Vascular Rejection in the Development of Interstitial Fibrosis and Transplant Glomerulopathy
(2017) Ozdemir, B. Handan; Ayva, S.; Baskin, E.; Ozdemir, F. Nurhan; Moray, G.; Haberal, M.; 0000-0002-7528-3557; 0000-0002-2280-8778; 0000-0003-4361-8508; 0000-0003-2498-7287; 0000-0002-3462-7632; X-8540-2019; AAK-1967-2021; B-5785-2018; AAE-1041-2021; AAJ-8097-2021
COMPARISON OF RAPAMYCIN WITH CYCLOSPORIN, AND TACROLIMUS IN REGARDS TO THE DEVELOPMENT OF EPITHELIAL-TO-MESENCHYMAL TRANSITION (EMT) OF TUBULAR CELLS AND ENDOTHELIAL-TO-MESENCHYMAL TRANSITION (ENDOMT) OF PERITUBULAR CAPILLARIES (PTCS)
(2020) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Atilgan, Alev Ok; Akcay, Eda; Polat, Aysegul Yucel; Akdur, Aydincan; Haberal, Mehmet A.
Development of Transplant Glomerulopathy in Recipients with Antibody Mediated Rejection: Activation of Inflammatory Pathway Through Renal Poly (Adp-Ribose) Polymerase (Parp)
(2017) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Baski, N. Esra; Moray, Gokhan; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-5682-0943; 0000-0003-2498-7287; 0000-0002-3462-7632; X-8540-2019; AAK-1697-2021; AAE-1041-2021; AAJ-8097-2021
GLOMERULAR DEPOSITS OF VON WILLEBRAND FACTOR (VWF) AND LOSS OF ENDOTHELIAL CELL SURFACE ANTIGENS ON PERITUBULAR CAPILLARIES (PTCS) SHOWED A STRONG ASSOCIATION WITH WORSE GRAFT OUTCOME IN RECIPIENTS WITH ANTIBODY-MEDIATED REJECTION (ABMR)
(2020) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Atilgan, Alev Ok; Akcay, Eda; Baskin, Eda; Haberal, Mehmet A.
The importance of age and CD4/CD8 ratio on the presenting time and the prognosis of the polyoma virus associated nephropathy (PVAN) after renal transplantation
(2019) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Baskin, Esra; Atilgan, Alev Ok; Moray, Gokhan; Haberal, Mehmet; 0000-0003-4361-8508; B-5785-2018
Influence of Hepatitis C Virus Infection on the Development of Interstitial Fibrosis and Transplant Glomerulopathy in Pediatric Renal Transplant Patients
(2017) Ozdemir, B. Handan; Baskin, E.; Ozdemir, F. Nurhan; Moray, G.; Haberal, M.; 0000-0002-7528-3557; 0000-0003-4361-8508; 0000-0002-5682-0943; 0000-0003-2498-7287; 0000-0002-3462-7632; X-8540-2019; B-5785-2018; AAK-1697-2021; AAE-1041-2021; AAJ-8097-2021
The influence of vitamin d3 treatment on the risk of development of acute rejection, epithelial-mesenchymal transition (EMT), and interstitial fibrosis among pediatric renal transplant patients
(2019) Ozdemir, B. Handan; Baskin, Esra; Ozdemir, F. Nurhan; Akcay, Eda Yilmaz; Moray, Gokhan; Haberal, Mehmet; 0000-0003-4361-8508; B-5785-2018
INTRA-PATIENT TACROLIMUS LEVEL VARIABILITY IN BK VIRUS ASSOCIATED NEPHROPATHY
(2020) Turgut, Didem; Topcu, Deniz Ilhan; Erdogmus, Siyar; Ozdemir, F. Nurhan; Kirnap, Mahir; Haberal, Mehmet A.
Poly (ADP-Ribose) Polymerase (PARP) Expression in Renal Allografts Augments the Development of Epithelial-Tomesenchymal Transition (EMT), Transplant Glomerulopathy, And Interstitial Fibrosis in Pediatric Patients With Antibodymediated Rejection
(2022) Atilgan, Alev Ok; Ozdemir, B. Handan; Baskin, Esra; Ozdemir, F. Nurhan; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0001-8595-8880; AAJ-8097-2021; AAK-3333-2021
Predictive Value of Renal Poly (Adp-Ribose) Polymerase (Parp) Expression Both in Inflammation and Interstitial Fibrosis Processes in Recipients with Antibody-Mediated Rejection
(2017) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Baskin, Esra; Moray, Gokhan; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-5682-0943; 0000-0003-4361-8508; 0000-0003-2498-7287; 0000-0002-3462-7632; X-8540-2019; AAK-1697-2021; B-5785-2018; AAE-1041-2021; AAJ-8097-2021
Pretransplant Renal Arterial Vasculopathy of Donor Predicts Poor Renal Allograft Survival
(2018) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Borcek, Pelin; Sercan, Cigdem; Ozdemir, Gokce; Soy, Ebru H. Ayvazoglu; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-5682-0943; 0000-0003-2545-0078; 0000-0002-0993-9917; 0000-0002-3462-7632; 29527990; X-8540-2019; AAK-1697-2021; AAL-4282-2020; AAC-5566-2019; AAJ-8097-2021
Objectives: Transplant vasculopathy is a significant predictor of poor outcome. We investigated whether age or pretransplant renal arterial vasculopathy of grafted kidneys affected allograft survival. Materials and Methods: This study included 148 recipients and their donors. All donors underwent pretransplant renal arterial biopsy, with renal artery vascular score determined for each artery. Chronic rejection and graft loss were noted for all patients. Results: Variable grades of pretransplant renal arterial lesions were noted in 103 donors (69.6%). A positive correlation was found between donor age and renal artery score (r = 0.650, P < .001), and chronic rejection and graft loss were found to increase with increasing score (P < .001). Recipient and donor age was significantly associated with graft loss and chronic rejection. With either younger or older donors, recipients had similar and best results regarding chronic rejection and graft loss if donors had renal artery scores of 0 or 1, but worse effects if donors had scores of 2 or 3. Five-year allograft survival rates for scores of 0, 1, 2, and 3 were 91%, 68%, 46%, and 33%. Univariate analyses showed that acute rejection episode (relative risk: 2.729, 95% confidence interval, 1.496-4.977; P= .001), older (>= 50 y) donor age (relative risk: 1.970, 95% confidence interval, 1.038-3.736; P = .04), and donor renal artery score (relative risk: 2.466, 95% confidence interval, 1.382-4.401; P = .002) were associated with decreased allograft survival. Multivariate Cox analysis showed that only acute rejection episode (relative risk: 3.585, 95% confidence interval, 1.781-7.217; P < .001) and renal artery score (relative risk: 2.642; 95% confidence interval, 1.355-5.150; P = .004) were independent predictors of allograft survival. Conclusions: Pretransplant vasculopathy in donor renal artery implies a poor prognosis for renal allograft survival and is independent of other risk factors. Pretransplant renal artery biopsy is recommended for both deceased and living donors, and therapeutic interventions to modify transplant vasculopathy progression should start early posttransplant in recipients with affected renal arteries.
RAPAMYCIN PREVENTS INTERSTITIAL FIBROSIS THROUGH DECREASING PERITUBULAR CAPILLARY (PTC) VEGF EXPRESSION AND ANGIOGENESIS WHILE INDUCING GLOMERULAR SCLEROSIS AND PROTEINURIA THROUGH DECREASING GLOMERULAR VEGF EXPRESSION
(2020) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Akcay, Eda; Atilgan, Alev Ok; Polat, Aysegul Yucel; Akdur, Aydincan; Haberal, Mehmet A.
Renal Allograft With Calcium Oxalate Deposition: Association with Urinary Tract Infection and Development of Interstitial Fibrosis
(2018) Ozdemir, B. Handan; Ayva, Sebnem; Ozdemir, Gokce; Atilgan, Alev Ok; Ozdemir, F. Nurhan; Haberal, Mehmet; 0000-0002-7528-3557; 0000-0002-2280-8778; 0000-0003-2545-0078; 0000-0001-8595-8880; 0000-0002-5682-0943; 0000-0002-3462-7632; 29528009; X-8540-2019; AAK-1967-2021; AAL-4282-2020; AAK-3333-2021; AAK-1697-2021; AAJ-8097-2021
Objectives: The interaction between calcium oxalate deposition and urinary tract infection is not well established. We aimed to identify the association between these and to determine the role of calcium oxalate deposition on interstitial fibrosis development. Materials and Methods: Renal allograft biopsies of 967 patients were reviewed to identify those with calcium oxalate deposition in the renal allograft, with 27 (2.8%) identified. Follow-up biopsies were conducted to reevaluate for calcium oxalate presence and interstitial fibrosis development. At time of biopsy, presence of urinary tract infection and oxaluria was also examined from medical records. Results: Mean time for development of calcium oxalate deposition in renal allografts was 1.7 +/- 0.4 and 32.7 +/- 21.6 months in patients with primary and secondary oxalosis, respectively (P < .001). Of 27 patients with calcium oxalate deposition, 7 (25.9%) showed tubulointerstitial nephritis, with 2 also having urinary tract infection. Four patients (14.8%) had only urinary tract infection. Causes of tubulointerstitial nephritis were secondary to bacterial infection in 2 and secondary to viral infection in 5 patients (2 polyomaviruses, 2 cytomegaloviruses, 1 adenovirus). Time until development of interstitial fibrosis after calcium oxalate deposition was 3.5 +/- 2.1 and 10.3 +/- 4.1 months in patients with primary and secondary oxalosis, respectively (P = .01). Time until graft loss after calcium oxalate deposition was 9.3 +/- 7.8 and 21.8 +/- 12 months in those with primary and secondary oxalosis (P < .001), with 1-, 3-, and 5-year kidney graft survival of 43%, 28%, and 0% and 100%, 100%, and 67% in those with primary and secondary oxalosis, respectively. Conclusions: Calcium oxalate deposits increased the risk of urinary tract infection and tubulointerstitial nephritis, with bacteria inducing increased presence of calcium oxalate deposition in a renal allograft. Calcium oxalate deposition had a significant influence on interstitial fibrosis development, therefore negatively affecting graft survival.
Simultaneous Vascular and Antibody-Mediated Rejection (AMR) in Pediatric Patients Caused Poor Prognosis in Renal Allograft
(2022) Atilgan, Alev Ok; Ozdemir, B. Handan; Baskin, Esra; Ozdemir, F. Nurhan; Haberal, Mehmet; 0000-0001-8595-8880; AAK-3333-2021
WHAT IS THE ROLE OF ENDOTHELIAL-TO-MESENCHYMAL TRANSITION (ENDOMT) OF RENAL CAPILLARIES ON THE RENAL OUTCOME BOTH IN ISOLATED TRANSPLANT GLOMERULOPATHY AND CHRONIC ANTIBODY-MEDIATED REJECTION (CAMR)
(2019) Ozdemir, B. Handan; Ozdemir, F. Nurhan; Akdur, Aydincan; Kirnap, Mahir; Moray, Gokhan; Haberal, Mehmet; AAH-9198-2019