Browsing by Author "Ozcurumez, Gamze"

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Association of Body Mass Index with Depression and Alexithymia
(2014) Karagol, Arda; Ozcurumez, Gamze; Taskintuna, Nilgun; Nar, Asli; https://orcid.org/0000-0002-3548-5517; https://orcid.org/0000-0003-0998-8388; ABE-8882-2020; AAK-3556-2021; AAA-2743-2021
Objective: Association between body mass index (BMI) and mental disorders had long been investigated. Recent researches declare a relation between obesity and depressed mood as well as clinical depression. On the other hand mental disorders such as alexithymia are also found to be correlated with an increased risk of obesity. Therefore we aimed to evaluate depression and alexithymia together among normal, overweight and obese adults in order to assess what kind of an association is there between BMI, depression and alexithymia. Methods: We enrolled 100 adults, aged between 18 to 67 from department of endocrinology outpatient clinic whom had normal levels of TSH, fT3 and fT4 thyroid hormones and formed three groups according to their Body Mass Index (BMI). Individuals who had had BMI between 18.5 and 24.99 formed the normal, BMI between 25 and 29.99 formed the overweight and BMI 30 and above formed the obese groups. All three groups were evaluated by Composite International Diagnostic Interview for clinical diagnosis and also given Toronto Alexithymia Scale-26 item (TAS-26) as well as Beck Depression Inventory (BDI). Results: There was a positive relation between BMI and current depressive episode and this finding was stronger in women. There was no such relation with lifelong depression. TAS-26 total and subscale scores revealed no difference between three groups. As BDI total scores got higher TAS-26 scores were higher. Hence there was a strong positive relation between depression and alexithymia. Conclusion: Our findings indicate that higher BMI increases current depressive episode. No association is found between BMI and lifelong depression. Depression and depression severity are strongly associated with alexithymia. Contradictive with literature, alexithymia and its severity are not found to be related with BMI. Following overweight and obese individuals is important to offset the adverse outcomes of depression.
Evaluation of Obsessive-Compulsive Disorder Patients According to Gender Differences
(2015) Altintas, Ebru; Ozcurumez, Gamze
Purpose: A homogenous classification cannot be obtained because of Obsessive Compulsive Disorder's (OCD) heterogeneous structure. The present study aimed to determine the relation of gender related differences with clinical features, symptom dimensions, age of onset, comorbidity in OCD patients. As distinct from the other studies we also aimed to evaluate the difference of Yale-Brown Obsessive Compulsive Scale's (Y-BOCS) subscales (insight, avoidance, pathologic doubt and pathologic responsibility, instability, retardation) between male and female patients with OCD. Method: The present study comprised of 198 patients aged between 15 and 65 years, who met the OCD criteria of DSM-IV-TR. Detailed data on clinical and sociodemographic characteristics were recorded. The patients were divided into two groups; male (n=65) and female (n=133). The patients underwent Structured Clinical Interview for DSM-IV Inventory (SCID-I), Yale-Brown Obsessive Compulsive Scale and Check List, Beck Anxiety Inventory, Beck Depression Inventory. Scores of these inventories were statistically compared. Results: There were no statistically significant differences in mean age, marital status, education level, family history, social support, hospitalization and suicidal attempt history between the two groups. We found a high treatment seeking, earlier age onset of obsessive-compulsive (OC) symptoms and disorder in males. We did not find any symptom differences except sexual obsession and repeating compulsion between male and female patients with OCD. We also found high BAI and BDI scores in females. We did not find statistically significant differences in the proportion of comorbid psychiatric disorders and the subscales of Y-BOCS between genders. Conclusion: The present study suggests that age of onset, treatment seeking, anxiety, depression level, and some OC symptoms are different between male and female patients and gender may be used for the classification of the OCD.
No Interaction Between Childhood Maltreatment and Serotonin Transporter Gene in Recurrent Major Depressive Disorder: A Clinical Sample
(2019) Ozcurumez, Gamze; Yurdakul, Hasan Talha; Terzi, Yunus; Direk, Nese; Essizoglu, Altan; Sahin, Feride; 0000-0001-5612-9696; 31223242; B-4372-2018
Introduction: There is inconsistent evidence of interaction between childhood adversities and a serotonin transporter promoter polymorphism (5- HTTLPR) in depression. It is hypothesized that genetic sensitivity to stress could be more specific to recurrent major depressive disorder (MDD). The aim of the study is to replicate a recent study which provided preliminary evidence of interaction between severity of childhood maltreatment and the 5-HTTLPR polymorphism in recurrent MDD. Methods: Participants included a well-characterized clinical sample of 70 recurrent MDD cases and 67 never psychiatrically ill controls, aged 18 years or over. Socio-demographic and clinical information form, Composite International Diagnostic Interview (CIDI), Childhood Trauma Questionnaire (CTQ), Beck Depression Inventory (BDI) were applied to both groups, along with genotyping. Results: There was no interaction between childhood maltreatment and the 5-HTTLPR in relation to recurrent MDD. All forms of childhood maltreatment were reported as more severe by cases than controls, and there was an independent association between maltreatment and recurrent MDD. Conclusion: The path forward to detect genetic risk loci for depression remains challenging. Taking childhood maltreatment history into account could lead to a richer understanding of differences in biological correlates, genetic underpinnings, and outcomes.