Browsing by Author "Ozcan, Deren"

Now showing 1 - 15 of 15

Acquired Aquagenic Syringeal Acrokeratoderma: A Case Series of 10 Patients
(2015) Erturk Ozdemir, Emel; Ozcan, Deren; Seckin, Deniz; 0000-0002-7450-6886; 24283504; AAQ-6649-2021
Aquagenic syringeal acrokeratoderma is a rare acquired disorder that predominantly affects young women. It is most commonly localised on the palms. It is characterised by translucent papules, oedematous plaques and keratoderma developing after brief exposure to water and resolving shortly after drying. We have observed 10 patients with this disorder within 13 months. We think that aquagenic syringeal acrokeratoderma is a more common condition than was originally anticipated as one can easily underdiagnose this entity due to the transient nature of its clinical findings.
Adult Still's disease: An unusual case with atypical skin and histopathological findings
(2020) Vural, Ayse Tuncer; Ozcan, Deren; Tepeoglu, Merih; 0000-0002-9894-8005; AAK-5222-2021
Adult Still's disease is a rare, acute systemic inflammatory disease characterized by a sudden rising fever, arthralgia/arthritis, neutrophilic leukocytosis and a typical salmon-colored macular or maculopapular rash associated elevated fever. Recently, atypical skin lesions with broad spectrum clinical features and distinctive histopathological findings have been reported in a rare case with active disease. Herein, we report an unusual case of Adult Still disease was presented and the characteristic features of atypical disease were highlighted.
Androgenetic Alopecia or Fibrosing Alopecia in a Pattern Distribution: When to Perform Biopsy in Unusual Cases?
(2022) Ozcan, Deren; Vural, Ayse Tuncer; Ozen, Ozlem; 35656261
Comparison of 10 versus 20 sessions tap water iontophoresis efficacy in the treatment of palmoplantar hyperhidrosis
(2022) Vural, Ayse Tuncer; Ozcan, Deren; Gulec, Ayse Tulin; https://orcid.org/0000-0001-8770-5721; 34982502; AAQ-4123-2021
Background Tap water iontophoresis (TWI) is an effective treatment option for palmoplantar hyperhidrosis (HH). However, the optimal number and frequency of TWI sessions to control profuse sweating are unclear. Objective To compare the efficacy of 10 and 20 sessions of TWI in patients with palmoplantar HH and determine the adequate number of sessions to achieve a favorable clinical response. Methods Eighty patients treated with TWI for palmoplantar HH were included. The alteration in sweating intensity considering the mean value of gravimetric measurement and mean visual analog scale (VAS) scores after the 10th and 20th session of TWI were calculated. The difference between performing 10 and 20 sessions of TWI in providing improvement of HH was analyzed. We also conducted a telephone-based inquiry to determine the patients' outcome. Results The reduction in sweating intensity was significant both after the 10th (p < 0.001) and 20th (p < 0.001) sessions when compared with the basal level considering gravimetry and VAS. When the mean sweating intensity after the 10th and 20th sessions were compared, no difference was observed gravimetrically (p = 0.03); the difference between the mean score of VAS after the 10th and 20th sessions (p < 0.001) was significant. Eleven and nine patients not considering a maintenance or an alternative treatment had lower and same sweating intensity as compared with the baseline, respectively. Conclusion Ten TWI sessions within two weeks for managing palmoplantar HH are adequate to achieve a clinical response. However, the patients are more satisfied when they receive 20 sessions instead of 10 sessions of TWI.
Compliance with Tap Water Iontophoresis in Patients with Palmoplantar Hyperhidrosis
(2014) Ozcan, Deren; Gulec, A. Tulin; https://orcid.org/0000-0002-7450-6886; 24636435; AAQ-6649-2021
Background: Patients tend to be noncompliant with tap water iontophoresis (TWI), which is an effective treatment option for palmoplantar hyperhidrosis. Objective: To investigate compliance with TWI in patients with palmoplantar hyperhidrosis and identify the factors limiting its utility. Methods: The medical data of 22 patients treated with TWI for palmoplantar hyperhidrosis were collected. A telephone inquiry questioning overall satisfaction with the treatment and the reasons for discontinuation was conducted. Results: Sixteen patients completed the initial treatment period, and all responded well to the therapy. Eight patients started on the maintenance treatment, five of whom gave up before completing five sessions. The reasons for discontinuation were a lack of time in 12 patients, switching to home therapy in 3 patients, and side effects in 1 patient. Conclusion: Patients with palmoplantar hyperhidrosis are noncompliant with TWI, mainly due to a lack of time. They should be well informed before therapy and be encouraged to have a home device for maintenance.
Diagnostic value of histopathologic examination in alopecias
(2014) Ozcan, Deren; Ozen, Ozlem; Seckin, Deniz
Alopecias are evaluated in two groups, namely noncicatricial type and cicatricial type. Cicatricial alopecias are generally irreversible due to the permenant damage to the hair follicles and as follicular epithelium is replaced by connective tissue in the late stages. In noncicatricial alopecia, the follicular epithelia is intact and hair regrowth is likely. The accurate diagnosis of alopecia subtypes which have different etiologies and occasionally result in permanent hair loss is of paramount importance to initiate the appropriate treatment in the early stages. Most of the subtypes of alopecia can be diagnosed with a detailed history and clinical evaluation. However, most of the disorders leading to alopecia present with nonspecific and overlapping clinical findings which alter over the course of the disease. In those instances, scalp biopsy and histopathologic evaluation is necessary to make or confirm the diagnosis. Transverse and vertical sections used for the interpretation of scalp biopsy specimens offer different advantages. Therefore, idealy, obtaining two 4 mm punch biopsy samples and combining both methods is suggested to enhance the diagnostic yield in patients with alopecia. In this review, the value of scalp biopsy in the diagnosis of subtypes of alopecia, the significance of evaluation of transverse and vertical sections in the histopathologic examination and the major histopathologic findings of the disorders involved in the etiology are described.
Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series
(2015) Durdu, Murat; Ozcan, Deren; Baba, Mete; Seckin, Deniz; 0000-0002-7450-6886; 0000-0003-1247-3932; 25653027; AAQ-6649-2021; H-9068-2019; HGU-2777-2022
Background: Some patients with chronic extensive alopecia areata (AA) may be refractory to topical immunotherapy. Combination therapy is recommended for such patients. Efficacy and safety of a combination therapy with diphenylcyclopropenone (DPCP) and anthralin in chronic extensive AA is unknown. Objective: We sought to determine whether the combination therapy of DPCP and anthralin is superior to DPCP alone in chronic extensive AA. Methods: We retrospectively analyzed the efficacy, side effects, and relapse rates of DPCP (alone or with anthralin) in chronic extensive AA. Results: A total of 47 patients (22 were treated only with DPCP, and 25 with DPCP and anthralin for at least 30 weeks) were evaluated. Complete hair regrowth was observed in 36.4% and 72% of the patients who received DPCP and combination therapy, respectively (P = .01). Hair regrowth duration was shorter with combination therapy (P = .01). Regrowth rates of the eyebrows, eyelashes, and beard in patients on combination therapy were higher than those in patients on DPCP (P = .01). Side effects such as folliculitis, hyperpigmentation, and staining of skin, hair, and clothes were more common in combination therapy group. Limitations: The retrospective design and small number of patients are limitations. Conclusion: Combination therapy with DPCP and anthralin is superior to DPCP alone in chronic extensive AA.
Intralesional triamcinolone acetonide in notalgia paresthetica: Treatment outcomes in five patients
(2020) Ozcan, Deren; Seckin, Deniz; Kibaroglu, Seda; Bernhard, Jeffrey D.; 0000-0002-7450-6886; 0000-0002-3964-268X; 32338414; AAQ-6649-2021; AAJ-2956-2021
Numerous treatment modalities have been tried with diverse results for pruritus due to notalgia paresthetica (NP). Corticosteroids suppress ectopic neural discharges from injured nerve fibers and also have short-lived suppressive effect on transmission in normal C-fibers. Herein, we evaluated the efficacy of intralesional triamcinolone acetonide in the treatment of NP. The medical reports of five patients who had been diagnosed with NP and treated with intralesional triamcinolone acetonide injections were retrospectively evaluated. Triamcinolone acetonide solution was injected intradermally (10 mg/mL; 0.1 mL/cm(2)) every 3 weeks for a maximum of four treatments. The severity of itch was scored by the patients on a combined numerical and visual analogue scale. After treatment, reduction in itch severity scores varied between 33% and 100%.
Kaposi's Sarcoma Beneath A Cutaneous Horn
(2014) Yavuzekinci, Umran; Ozcan, Deren; Gulec, Ayse Tulin; https://orcid.org/0000-0002-7450-6886; 23331071; AAQ-6649-2021
Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases
(2015) Ozcan, Deren; Seckin, Deniz; Gulec, A.Tulin; Ozen, Ozlem; 0000-0002-7450-6886; 0000-0002-9082-1317; AAQ-6649-2021; AAK-4468-2021
Background and Design: Lichen planopilaris (LPP) is a type of cicatricial alopecia characterized by autoreactive lymphocytic destruction of the hair follicle. We aimed to evaluate the demographic, clinical and histopathological features, and treatment outcomes of patients with LPP. Materials and Methods: Medical reports of 25 patients, who have been diagnosed with LPP according to the clinical and histopathological findings between January 2006 and June 2012, were retrospectively reviewed. The transverse and vertical sections of scalp biopsy specimens were re-evaluated by a pathologist, and the findings were noted. Results: Of the 25 patients, 18 were female and 7 were male, the mean age was 49.8 +/- 12.4 years. Eighteen patients had been diagnosed with classic LPP and 7 patients with frontal fibrosing alopecia (FFA). The alopecia has begun in postmenopausal period in 5 patients with FFA. Alopecia was associated with pruritus, pain and/or burning in 19 patients. Extra-scalp involvement was observed in 11 patients. The most common clinical findings were follicular hyperkeratosis (92%), perifollicular erythema (48%), perifollicular lichenoid papules, and positive hair-pull test (44%). Dermatoscopic examination was performed in 14 patients, and most commonly, absence of follicular openings (100%), perifollicular scales (92.9%) and perifollicular erythema (50%) were noted. The most common diagnostic histopathological findings were follicular vacuolar and lichenoid degeneration (88%) and vacuolar and lichenoid interface changes (56%). Twenty-three patients who were started on treatment received topical, intramuscular and intralesional corticosteroids, topical minoxidil, oral tetracycline, cyclosporine A, and hydroxychloroquine either alone or in combination. Progression of alopecia was prevented and the symptoms and/or signs were reduced in 12 (75%) of 16 patients whose follow-up data were available. Conclusion: LPP can be diagnosed accurately through a detailed clinical examination, dermatoscopy and histopathological examination. The symptoms and/or signs can be reduced and progression of the disease can be prevented with treatment.
A Multicenter Survey: How Do Transplant Dermatologists Monitor Organ Transplant Recipients With Nevi?
(2018) Ozcan, Deren; Seckin, Deniz; Haberal, Mehmet; 0000-0002-7450-6886; 0000-0002-3462-7632; 29528027; AAQ-6649-2021; AAJ-8097-2021
Objectives: The incidence and mortality of melanoma are increased in organ transplant recipients. Multiple acquired common and dysplastic nevi are risk factors for melanoma. A new or changing nevus may suggest melanoma. Strategies used by transplant dermatologists to monitor nevi are unknown. Herein, we aimed to assess the methods used by transplant dermatologists for monitoring multiple acquired common nevi, dysplastic nevi, and new or changing nevi. Materials and Methods: A questionnaire was e-mailed to 63 members of the Skin Care in Organ Transplant Patients, Europe. Results: Thirty-eight (92.7%) of 41 responders reported that they instruct their patients to perform regular self-skin examinations. Of 41 responders, 41.5% prescribed screening every 6 months, 36.6% prescribed it every 12 months, 12.2% prescribed it every 3 months, and 9.7% performed screening without regular intervals. Regarding type of examination, 80.5% performed full-body skin examinations with the naked eye, 70.7% performed dermoscopy of clinically suspicious nevi, 53.6% offered dermoscopic photography of dermoscopically suspicious nevi, 36.6% provided close-up photography of clinically suspicious nevi, 34.1% performed baseline total body photography, and 24.4% conducted dermoscopy of all nevi. We also found that 7.3%, 4.9%, and 4.9% performed only full-body skin examination with the naked eye, only dermoscopy of clinically suspicious nevi, and only dermoscopy of all nevi, respectively. Conclusions: Dedicated transplant dermatologists perform a wide variety of nevi screening procedures in organ transplant recipients. Transplant dermatologists should include sequential digital dermoscopic imaging in their armamentarium to follow organ transplant recipients with melanocytic lesions. A combination of techniques is advisable for detecting early posttransplant melanomas.
N-Acetylcysteine for Managing Neurotic Excoriation: Encouraging Results in Two Patients
(2021) Ozcan, Deren; 0000-0002-7450-6886; 33781651; AAQ-6649-2021
Pediatric Androgenetic Alopecia: A Retrospective Review Of Clinical Characteristics, Hormonal Assays And Metabolic Syndrome Risk Factors In 23 Patients
(2022) Ozcan, Deren; https://orcid.org/0000-0002-7450-6886; 35033390; AAQ-6649-2021
Background: Androgenetic alopecia in the pediatric population is rarely discussed in the literature. Although the prevalence of the metabolic syndrome is increased in patients with early-onset androgenetic alopecia, the presence of metabolic syndrome risk factors in pediatric androgenetic alopecia is unknown. Objective: To evaluate the demographics, medical and family histories, clinical and trichoscopic features, androgenic hormones, and metabolic syndrome risk factors in pediatric androgenetic alopecia. Methods: The medical reports of pediatric patients with androgenetic alopecia were reviewed. Results: The study included 23 patients (12 females and 11 males) with a mean age of 15,3 +/- 2,1 years. Sixteen patients had adolescent androgenetic alopecia and seven, had childhood alopecia. Nine patients reported a family history, all of whom had adolescent androgenetic alopecia. Hyperandrogenism was noted in three patients with adolescent androgenetic alopecia. The most common hair loss pattern was diffuse thinning at the crown with preservation of the frontal hairline which was noted in 10 patients (43.5%), six of whom were males. Fourteen patients (60.9%) had at least one metabolic syndrome risk factor. The most common risk factor was obesity or overweight (47.8%) followed by insulin resistance (21.7%), high fasting blood glucose (13%), high blood pressure (4.4%) and lipid abnormalities (4.4%). Study limitations: Retrospective study; lack of a control group. Conclusion: Pediatric androgenetic alopecia is often associated with metabolic syndrome risk factors. Therefore, androgenetic alopecia in the pediatric population may indicate a future metabolic syndrome which warrants an accurate and prompt diagnosis for early screening and treatment. (C) 2021 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U.
Platelet-rich plasma for treatment resistant frontal fibrosing alopecia: A case report
(2019) Ozcan, Deren; Vural, Ayse Tuncer; Ozen, Ozlem; 0000-0002-7450-6886; 31443128
Two cases of fibrosing alopecia in a patterned distribution after coronavirus disease 2019
(2021) Ozcan, Deren; Vural, Ayse Tuncer; Ozen, Ozlem; 0000-0002-7450-6886; 0000-0001-8770-5721; 34491674; AAQ-6649-2021; AAQ-4123-2021